Detalhe da pesquisa
1.
GOT1 constrains TH17 cell differentiation, while promoting iTreg cell differentiation.
Nature
; 614(7946): E1-E11, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36726001
2.
Enhanced Oral Bioavailability of 2-(Phosphonomethyl)-pentanedioic Acid (2-PMPA) from its (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-Based Prodrugs.
Mol Pharm
; 16(10): 4292-4301, 2019 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31503493
3.
Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.
Proc Natl Acad Sci U S A
; 113(36): E5328-36, 2016 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27559084
4.
Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs.
Mol Pharm
; 14(10): 3248-3257, 2017 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28763226
5.
Prostate-specific membrane antigen (PSMA)-mediated laminin proteolysis generates a pro-angiogenic peptide.
Angiogenesis
; 19(4): 487-500, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27387982
6.
D-Amino acid oxidase inhibitors based on the 5-hydroxy-1,2,4-triazin-6(1H)-one scaffold.
Bioorg Med Chem Lett
; 26(8): 2088-91, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26965861
7.
Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine.
J Neurovirol
; 21(2): 159-73, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25645378
8.
Bioanalysis of 6-diazo-5-oxo-l-norleucine in plasma and brain by ultra-performance liquid chromatography mass spectrometry.
Anal Biochem
; 474: 28-34, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25584882
9.
Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis.
Proc Natl Acad Sci U S A
; 109(49): 20101-6, 2012 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-23169655
10.
Glutamate carboxypeptidase II is not an amyloid peptide-degrading enzyme.
FASEB J
; 27(7): 2620-5, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23525278
11.
Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.
Bioorg Med Chem
; 22(21): 5831-7, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25288495
12.
Metabolic reprogramming of tumor-associated macrophages using glutamine antagonist JHU083 drives tumor immunity in myeloid-rich prostate and bladder cancer tumors.
Cancer Immunol Res
; 2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38701369
13.
Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase.
Bioorg Med Chem Lett
; 23(13): 3910-3, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23683589
14.
Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy.
J Control Release
; 358: 27-42, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37054778
15.
Discovery of tert-Butyl Ester Based 6-Diazo-5-oxo-l-norleucine Prodrugs for Enhanced Metabolic Stability and Tumor Delivery.
J Med Chem
; 66(22): 15493-15510, 2023 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37949450
16.
Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis.
Nat Commun
; 14(1): 7427, 2023 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37973991
17.
Preclinical Efficacy of LP-184, a Tumor Site Activated Synthetic Lethal Therapeutic, in Glioblastoma.
Clin Cancer Res
; 29(20): 4209-4218, 2023 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37494541
18.
Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold.
Eur J Med Chem
; 259: 115674, 2023 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37536209
19.
A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis.
Sci Transl Med
; 15(708): eabn7491, 2023 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37556558
20.
Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor.
Mol Cancer Ther
; 22(12): 1390-1403, 2023 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37616542