Detalhe da pesquisa
1.
Targeting SARS-CoV-2 Main Protease: A Successful Story Guided by an In Silico Drug Repurposing Approach.
J Chem Inf Model
; 63(11): 3601-3613, 2023 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37227780
2.
Short- and Long-Term Regulation of HuD: A Molecular Switch Mediated by Folic Acid?
Int J Mol Sci
; 24(15)2023 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37569576
3.
Natural Agents as Novel Potential Source of Proteasome Inhibitors with Anti-Tumor Activity: Focus on Multiple Myeloma.
Molecules
; 28(3)2023 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36771100
4.
From Nature to Synthetic Compounds: Novel 1(N),2,3 Trisubstituted-5-oxopyrrolidines Targeting Multiple Myeloma Cells.
Int J Mol Sci
; 23(21)2022 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36361848
5.
Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach.
Molecules
; 27(21)2022 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36364347
6.
Key genetic elements, single and in clusters, underlying geographically dependent SARS-CoV-2 genetic adaptation and their impact on binding affinity for drugs and immune control.
J Antimicrob Chemother
; 76(2): 396-412, 2021 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33254234
7.
Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses.
Drug Resist Updat
; 53: 100721, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33132205
8.
Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa-Part 2.
Molecules
; 26(21)2021 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34771006
9.
AutoDock Bias: improving binding mode prediction and virtual screening using known protein-ligand interactions.
Bioinformatics
; 35(19): 3836-3838, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30825370
10.
D3R Grand Challenge 4: prospective pose prediction of BACE1 ligands with AutoDock-GPU.
J Comput Aided Mol Des
; 33(12): 1071-1081, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31691920
11.
Comparison of affinity ranking using AutoDock-GPU and MM-GBSA scores for BACE-1 inhibitors in the D3R Grand Challenge 4.
J Comput Aided Mol Des
; 33(12): 1011-1020, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31691919
12.
Neurodegeneration: can metabolites from Eremurus persicus help?
Front Pharmacol
; 15: 1309766, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38370479
13.
New Insights for Polyphenolic Compounds as Naturally Inspired Proteasome Inhibitors.
Pharmaceuticals (Basel)
; 16(12)2023 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38139838
14.
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands.
ACS Chem Neurosci
; 14(10): 1845-1858, 2023 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37155827
15.
Molecular and Structural Aspects of Clinically Relevant Mutations of SARS-CoV-2 RNA-Dependent RNA Polymerase in Remdesivir-Treated Patients.
Pharmaceuticals (Basel)
; 16(8)2023 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37631058
16.
Identification of HuR-RNA Interfering Compounds by Dynamic Combinatorial Chemistry and Fluorescence Polarization.
ACS Med Chem Lett
; 14(11): 1509-1516, 2023 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37970588
17.
In Silico-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists.
J Med Chem
; 66(10): 6994-7015, 2023 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37192374
18.
Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity.
J Med Chem
; 66(16): 11447-11463, 2023 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37535861
19.
Update on SARS-CoV-2 Omicron Variant of Concern and Its Peculiar Mutational Profile.
Microbiol Spectr
; 10(2): e0273221, 2022 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35352942
20.
Identification of Compounds Targeting HuD. Another Brick in the Wall of Neurodegenerative Disease Treatment.
J Med Chem
; 64(14): 9989-10000, 2021 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34219450