Evaluation of chimeric recombinant antigens for the serodiagnosis of Trypanosoma cruzi in dogs: a promising tool for Chagas disease surveillance.

BACKGROUND: Chagas disease (CD), a neglected parasitic disease caused by Trypanosoma cruzi, poses a significant health threat in Latin America and has emerged globally because of human migration. Trypanosoma cruzi infects humans and over 100 other mammalian species, including dogs, which are important sentinels for assessing the risk of human infection. Nonetheless, the serodiagnosis of T. cruzi in dogs is still impaired by the absence of commercial tests. In this study, we investigated the diagnostic accuracy of four chimeric recombinant T. cruzi IBMP antigens (IBMP-8.1, IBMP-8.2, IBMP-8.3, and IBMP-8.4) for detecting anti-T. cruzi antibodies in dogs, using latent class analysis (LCA). METHODS: We examined 663 canine serum samples, employing indirect ELISA with the chimeric antigens. LCA was utilized to establish a latent variable as a gold standard for T. cruzi infection, revealing distinct response patterns for each antigen. RESULTS: The IBMP (Portuguese acronym for the Molecular Biology Institute of Paraná) antigens achieved area under the ROC curve (AUC) values ranging from 90.9% to 97.3%. The highest sensitivity was attributed to IBMP-8.2 (89.8%), while IBMP-8.1, IBMP-8.3, and IBMP-8.4 achieved 73.5%, 79.6%, and 85.7%, respectively. The highest specificity was observed for IBMP-8.4 (98.6%), followed by IBMP-8.2, IBMP-8.3, and IBMP-8.1 with specificities of 98.3%, 94.4%, and 92.7%, respectively. Predictive values varied according to prevalence, indicating higher effectiveness in endemic settings. CONCLUSIONS: Our findings underscore the remarkable diagnostic performance of IBMP-8.2 and IBMP-8.4 for the serodiagnosis of Trypanosoma cruzi in dogs, representing a promising tool for the diagnosis of CD in dogs. These chimeric recombinant antigens may not only enhance CD surveillance strategies but also hold broader implications for public health, contributing to the global fight against this neglected tropical disease.

Patterns of metabolic syndrome and associated factors in women from the ELSA-Brasil: a latent class analysis approach.

This study aimed to identify patterns of metabolic syndrome among women and estimate their prevalence and relationship with sociodemographic and biological characteristics. In total, 5,836 women were evaluated using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Patterns of metabolic syndrome were defined via latent class analysis, using the following metabolic abnormalities as indicators: abdominal obesity, hyperglycemia, hypertension, hypertriglyceridemia, and reduced HDL cholesterol. The relationship between these patterns and individual characteristics was assessed using latent class analysis with covariates. Three patterns of metabolic syndrome were identified: high metabolic expression, moderate metabolic expression, and low metabolic expression. The first two patterns represented most women (53.8%) in the study. Women with complete primary or secondary education and belonging to lower social classes were more likely to have higher metabolic expression. Black and mixed-race women were more likely to have moderate metabolic expression. Menopausal women aged 50 years and older were more often classified into patterns of greater health risk. This study addressed the heterogeneous nature of metabolic syndrome, identifying three distinct profiles for the syndrome among women. The combination of abdominal obesity, hyperglycemia, and hypertension represents the main metabolic profile found among ELSA-Brasil participants. Sociodemographic and biological factors were important predictors of patterns of metabolic syndrome.

[Perceived neighborhood characteristics and practice of physical activity among adolescents and young adults: a model with distal outcomes]. / Características percebidas da vizinhança e a prática de atividade física entre adolescentes e adultos jovens: um modelo com respostas distais.

This study aimed to identify neighborhood profiles perceived by adolescents and young adults and estimate their association with global and leisure-time physical activity. Data from 1,637 individuals aged 15 to 24 years were taken from a cross-sectional study with cluster sampling, conducted in a city in the State of Bahia, Brazil, in 2011. Physical activity was measured using the International Physical Activity Questionnaire (IPAQ), short version, in addition to a question about leisure activities. The perception of characteristics of the physical and social environment of the neighborhood was based on a scale with 14 questions. Neighborhood profiles were defined through latent class analysis (LCA), and the estimation of their effects on physical activity used a model with distal outcomes. The latent profile analysis resulted in three neighborhood patterns, described as "urban, sociable, and favorable to physical activity - class 1" (39.6%); "sociable and safe - class 2" (24.4%), "insecure, low sociability - class 3" (36%). Individuals belonging to "class 1" showed the highest probability to exercise (56.4%), while for classes 2 and 3 these percentages corresponded to 46.3% and 42.8%, respectively. A statistically significant association was identified only in the "urban, sociable and favorable to physical activity" class, whose chance of performing leisure activities was 72% (OR = 1.72; 95%CI: 1.29-2.29). Neighborhoods with attributes that favor the practice of physical activity and the existence of urbanization elements increase the chance of active leisure behavior among adolescents and young adults. The use of LCA and the model with distal outcomes are promising and innovative in neighborhood approaches.

Os objetivos do estudo foram identificar perfis de vizinhança percebidos por adolescentes e adultos jovens, e estimar sua associação com a realização de atividade física global e de lazer. Utilizaram-se dados de 1.637 indivíduos entre 15 e 24 anos, de um estudo transversal, com amostragem por conglomerados, de uma cidade do Estado da Bahia, Brasil, em 2011. A atividade física foi mensurada pelo International Physical Activity Questionnaire (IPAQ), versão curta, além de questão sobre atividade no lazer. A percepção de características do ambiente físico e social da vizinhança se baseou em escala com 14 questões. Perfis de vizinhança foram definidos por meio de análise de classes latentes (LCA), e a estimação dos seus efeitos na atividade física usou o modelo com respostas distais. A análise de perfil latente resultou em três padrões de vizinhança, descritos como "urbana, sociável e favorável à atividade física - classe 1" (39,6%); "sociável e segura - classe 2" (24,4%); e "insegura, de baixa sociabilidade - classe 3" (36%). Os indivíduos pertencentes à "classe 1" apresentaram maior probabilidade de se exercitar (56,4%), enquanto, para as classes 2 e 3, estes percentuais corresponderam a 46,3% e 42,8%, respectivamente. Associação estatisticamente significante foi identificada apenas na classe "urbana, sociável e favorável à atividade física", cuja chance de realizar atividade de lazer foi de 72% (OR = 1,72; IC95%: 1,29-2,29). Bairros com atributos favoráveis à prática de atividade física e a existência de elementos de urbanização aumentam a chance do comportamento ativo no lazer entre os adolescentes e adultos jovens. O uso de LCA e do modelo com repostas distais é promissor e inovador na abordagem sobre vizinhança.

Los objetivos del estudio fueron identificar los perfiles de vecindario percibidos por los adolescentes y los adultos jóvenes y estimar su asociación con la realización de actividad física global y de ocio. Se utilizaron datos de 1.637 individuos entre 15 y 24 años, procedentes de un estudio transversal, con muestreo por conglomerados, de una ciudad del estado de Bahia, Brasil, en 2011. La actividad física se midió mediante el International Physical Activity Questionnaire (IPAQ), versión corta, además de una pregunta sobre actividad en el ocio. La percepción de las características del entorno físico y social del vecindario se basó en una escala con 14 preguntas. Los perfiles de la vecindad se definieron a través del análisis de clase latente (ACL), y la estimación de sus efectos sobre la actividad física utilizó el modelo con respuestas distales. El análisis de perfil latente dio como resultado tres patrones de vecindario, descritos como "urbano, sociable y favorable a la actividad física - clase 1" (39,6 %); "sociable y seguro - clase 2" (24,4 %), "inseguro, de baja sociabilidad - clase 3" (36%). Los individuos pertenecientes a la "clase 1" presentaron la mayor probabilidad de hacer ejercicio (56,4 %), mientras que para las clases 2 y 3 estos porcentajes correspondieron a 46,3 % y 42,8 %, respectivamente. Solamente se identificó una asociación estadísticamente significativa en la clase "urbana, sociable y favorable a la actividad física", cuya probabilidad de realizar actividad de ocio fue de 72 % (OR = 1,72; IC95%: 1,29-2,29). Los barrios con atributos favorables para la actividad física y la existencia de elementos de urbanización aumentan la posibilidad de un comportamiento activo en el ocio entre los adolescentes y los adultos jóvenes. El uso de ACL y el modelo con respuestas distales son enfoques prometedores e innovadores para la vecindad.

Ideal cardiovascular health at ELSA-Brasil: non-additivity effects of gender, race, and schooling by using additive and multiplicative interactions.

This study aims to assess the non-additivity effects of gender, race, and schooling on ideal cardiovascular health among participants of the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil. This is a cross-sectional study using data from the baseline of ELSA-Brasil, conducted from 2008 to 2010. The American Heart Association defined a score of ideal cardiovascular health (ICH) as the sum of indicators for the presence of seven favorable health factors and behaviors: non-smoking, ideal body mass index, physical activity and healthy diet, adequate levels of total cholesterol, normal blood pressure, and absence of diabetes mellitus. Multiplicative and additive interactions between gender, race, and schooling were assessed using the Poisson regression model to discuss intersectionality. The mean cardiovascular health score was 2.49 (SD = 1.31). This study showed a positive interaction between gender and schooling (women with high school and higher education) in both additive and multiplicative scales for the score of ideal cardiovascular health. We observed a trend towards higher mean values of cardiovascular health for increased schooling, with a marked difference among women. The lowest cardiovascular health scores observed reinforce the importance of understanding the psychosocial experiences that influence health attitudes, access to health care, and healthy lifestyle choices, which affect ICH, to reduce inequities in health and propose more adequate public policies that assist and prevent cardiovascular diseases.

Performance evaluation of tuberculosis control in Brazilian municipalities.

OBJECTIVE: To evaluate the performance of tuberculosis control in Brazilian municipalities. METHODS: This is an ecological study on Brazilian municipalities that notified at least four new cases of tuberculosis, with a minimum of one new case of pulmonary tuberculosis between 2015 and 2018. The municipalities were stratified according to the population in < 50 thousand, 50-100 thousand, 100-300 thousand, and > 300 thousand inhabitants, and the k-means method was used to group them within each population range according to the performance of six indicators of the disease. RESULTS: A total of 2,845 Brazilian municipalities were included, comprising 98.5% (208,007/211,174) of new tuberculosis cases in the period. For each population range, three groups (A, B, and C) of municipalities were identified according to the performance of the indicators: A, the most satisfactory; B, the intermediates; and C, the least satisfactory. Municipalities in group A with < 100 thousand inhabitants presented results above the targets for laboratory confirmation (≥ 72%), abandonment (≤ 5%), and cure (≥ 90%), and comprised 2% of new cases of the disease. Conversely, municipalities of groups B and C presented at least five indicators with results below the targets - HIV testing (< 100%), contact investigation (< 90%), directly observed therapy (< 90%), abandonment (> 5%), and cure (< 90%) -, and corresponded to 66.7% of new cases of tuberculosis. In group C of municipalities with > 300 thousand inhabitants, which included 19 of the 27 capitals and 43.1% of new cases of tuberculosis, the lowest percentages of contact investigation (mean = 56.4%) and directly observed therapy (mean = 15.4%) were verified, in addition to high abandonment (mean = 13.9%) and low coverage of primary health care (mean = 66.0%). CONCLUSIONS: Most new cases of tuberculosis occurred in municipalities with unsatisfactory performance for disease control. Expanding the coverage of primary health care in these places can reduce abandonment and increase the contact investigation and directly observed therapy.

Social position and anthropometric status among adults in the ELSA-Brasil study: a latent class analysis.

The objective of the present study was to evaluate the association between social position and anthropometric status in women and men Brazilian adult. This was a cross-sectional study that used baseline data collected from 2008 to 2010 for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil, in Portuguese), in the six major Brazilian state capital cities. A total of 15,105 active and retired civil servants aged from 35 to 74 years. Two latent variables were defined by latent class analysis, social position and anthropometric status. Both constructs and the analyses were separately evaluated by sex. Associations were assessed using multivariate logistic regression analysis with adjustment for age, self-reported skin color/race, and marital status. Around 44% of the women and 26% of the men were classified as overweight or obese. Social position tended to be lower in women (43.2%) and higher among men (40.4%). Heavier women were more likely to be black and brown-skinned, whereas slimmer women were more likely to be white. After adjustment, women's weight increased as social position decreased (OR = 1.52; 95%CI: 1.36-1.70), whereas in men weight decreased as social position decreased (OR = 0.87; 95%CI: 0.76-0.99). Social position affected the anthropometric status of women and men differently, with body patterns also being affected by ethnicity/skin color, showing the potentiality of taking the intersectional perspective when investigating the possible social determinants of the phenomenon.

Immune response dynamics and Lutzomyia longipalpis exposure characterize a biosignature of visceral leishmaniasis susceptibility in a canine cohort.

BACKGROUND: Reports have shown correlations between the immune response to vector saliva and Leishmaniasis outcome. We followed dogs in an endemic area for two years characterizing resistance or susceptibility to canine visceral leishmaniasis (CVL) according to Leishmania infantum diagnosis and clinical development criteria. Then, we aimed to identify a biosignature based on parasite load, serum biological mediators' interactions, and vector exposure intensity associated with CVL resistance and susceptibility. METHODOLOGY/PRINCIPAL FINDINGS: A prospective two-year study was conducted in an area endemic for CVL. Dogs were evaluated at 6-month intervals to determine infection, clinical manifestations, immune profile, and sandfly exposure. CVL resistance or susceptibility was determined upon the conclusion of the study. After two years, 78% of the dogs were infected with L. infantum (53% susceptible and 47% resistant to CVL). Susceptible dogs presented higher splenic parasite load as well as persistence of the parasite during the follow-up, compared to resistant ones. Susceptible dogs also displayed a higher number of correlations among the investigated biological mediators, before and after infection diagnosis. At baseline, anti-saliva antibodies, indicative of exposure to the vector, were detected in 62% of the dogs, reaching 100% in one year. Higher sandfly exposure increased the risk of susceptibility to CVL by 1.6 times (CI: 1.11-2.41). We identified a discriminatory biosignature between the resistant and susceptible dogs assessing splenic parasite load, interaction of biological mediators, PGE2 serum levels and intensity of exposure to sandfly. All these parameters were elevated in susceptible dogs compared to resistant animals. CONCLUSIONS/SIGNIFICANCE: The biosignature identified in our study reinforces the idea that CVL is a complex multifactorial disease that is affected by a set of factors which are correlated and, for a better understanding of CVL, should not be evaluated in an isolated way.

[Abdominal obesity in ELSA-Brasil (Brazil's Longitudinal Study of Adult Health): construction of a latent gold standard and evaluation of the accuracy of diagnostic indicators]. / Obesidade abdominal no ELSA-Brasil: construção de padrão-ouro latente e avaliação da acurácia de indicadores diagnósticos.

This study evaluated the accuracy of abdominal obesity (AO) indicators, defining a latent variable as the gold standard. The study included 12,232 participants of the ELSA-Brasil (Brazil's Longitudinal Study of Adult Health), between 35 and 74 years of age. Three AO indicators were evaluated: waist circumference (WC), waist hip ratio (WHR) and conicity index (C index). Analyses were stratified by sex and race/skin color. All groups had a high prevalence of AO, being greater among white men (~70%) and black women (~60%). A high incidence of WC was observed for men, WHR and C index between men and women for discriminating latent AO. The following cutoff points for AO indicators were identified among white, brown and black men, respectively: WC: 89.9cm; 90.2cm and 91.7cm; WHR: 0.92; 0.92 and 0.90; C index: 1.24; 1.24 and 1.24. The cutoff points identified among white, brown and black women were, respectively: WC: 80.4cm, 82.7cm and 85.4cm; WHR: 0.82; 0.83 and 0.84; C index: 1.20; 1.22 and 1.19 The WC among men and the WHR and C index among men and women presented high power to discriminate latent AO, the C index being the best indicator.

Este estudo avaliou a acurácia de indicadores de obesidade abdominal (OA), definindo uma variável latente como padrão-ouro. Foram estudados 12.232 participantes do ELSA-Brasil de 35 a 74 anos. Avaliou-se três indicadores de OA, estratificados por sexo e raça/cor: circunferência da cintura (CC), razão cintura quadril (RCQ) e índice de conicidade (Índice C). Todos os grupos mostraram elevadas prevalências de OA, maiores entre os homens brancos (~70%) e mulheres pretas (~60%). Observou-se alta acurácia da CC para homens, RCQ e índice C entre homens e mulheres para discriminar OA latente. Identificou-se os seguintes pontos de corte para os indicadores de OA entre os homens brancos, pardos e pretos, respectivamente: CC: 89,9; 90,2 e 91,7cm; RCQ: 0,92; 0,92 e 0,90; índice C: 1,24; 1,24 e 1,24. Para as mulheres brancas, pardas e pretas, respectivamente, os pontos de corte identificados foram: CC: 80,4; 82,7 e 85,4cm; RCQ: 0,82; 0,83 e 0,84; índice C: 1,20; 1,22 e 1,19. A CC entre os homens e a RCQ e índice C entre homens e mulheres apresentaram alto poder para discriminar OA latente, sendo o índice C o melhor indicador.

[Adolescent and youth access to primary health care services in a city in the state of Bahia, Brazil]. / Acesso aos serviços de atenção primária à saúde por adolescentes e jovens em um município do Estado da Bahia, Brasil.

The study sought to analyze the association between adolescents and young adults' access to primary health care services and Family Health Strategy (FHS) services. It is a cross-sectional study based on a household survey of 812 individuals aged between 15 and 24 years in Camaçari, Bahia State, Brazil, through cluster sampling. Demographic, socioeconomic, health and health service variables were used to describe the population according to primary health care area. The association between primary health care coverage area and access to its services, access barriers and participation in educational activities were estimated through prevalence ratios (PR) using multilevel logistic regression models in the R software. Access to primary health care services was reported by 89.5% of individuals, with no statistically significant differences between this type of access and primary health care coverage area. However, among individuals who reside in areas covered by FHS, there was greater access to harm reduction and health promotion actions (PR = 3.0; 95%CI: 1.68-5.34), but also lower probability of being seen by a health worker on the same day the appointment was scheduled (PR = 0.60; 95%CI: 0.48-0.74) and lower availability of public transportation (RP = 0.59; 95%CI: 0.39-0.90). Study results point to a high prevalence of access to primary health care services among adolescents and young adults. Though we did not observe a difference in access between areas with FHS coverage, young people's greater participation in prevention and health promotion activities reinforces this strategy's importance within Brazilian Unified National Health System (SUS).

O estudo teve como objetivo analisar a associação entre o acesso aos serviços de atenção primária à saúde dos adolescentes e adultos jovens e a cobertura da Estratégia Saúde da Família (ESF). Trata-se de estudo transversal, a partir de um inquérito domiciliar realizado com 812 indivíduos de 15 a 24 anos de idade, em Camaçari, Bahia, Brasil, por meio de uma amostragem por conglomerados. Variáveis demográficas, socioeconômicas, de saúde e dos serviços de saúde foram utilizadas para descrição da população, segundo a área de cobertura de atenção primária à saúde. A associação entre área de cobertura da atenção primária à saúde e acesso aos serviços desta, as barreiras de acesso e a participação em atividades educativas foram estimadas por meio da razão de prevalência (RP), com uso do modelo de regressão logística multinível no software R. O acesso aos serviços de atenção primária à saúde foi referido por 89,5% dos indivíduos, não havendo diferenças estatisticamente significantes entre esse tipo de acesso e a área de cobertura da ESF. Entretanto, entre indivíduos residentes em áreas cobertas pela ESF, verificou-se maior acesso às ações de prevenção de agravos e promoção da saúde (RP = 3,0; IC95%: 1,68-5,34), mas também menor probabilidade de o atendimento ocorrer no mesmo dia de marcação da consulta (RP = 0,60; IC95%: 0,48-0,74) e menor disponibilidade de transporte coletivo (RP = 0,59; IC95%: 0,39-0,90). Os dados deste estudo apontaram elevada prevalência de acesso aos serviços de atenção primátria à saúde entre os adolescentes e adultos jovens. Ainda que não se tenham observado diferenças do acesso entre as áreas com cobertura da ESF, a maior participação desses indivíduos em atividades de prevenção e promoção da saúde reforçam a importância dessa estratégia no âmbito do Sistema Único de Saúde (SUS).

El objetivo de este estudio fue analizar la asociación entre el acceso a los servicios de atención primaria en salud de adolescentes y adultos jóvenes y la cobertura de la Estrategia de Salud Familiar (ESF). Se trata de un estudio transversal, a partir de una encuesta domiciliaria, realizada con 812 individuos de 15 a 24 años de edad, en Camaçari, Bahía, Brasil, mediante una muestra por conglomerados. Se utilizaron variables demográficas, socioeconómicas, de salud y de servicios de salud para la descripción de la población, según el área de cobertura de atención primaria en salud. La asociación entre área de cobertura de la atención primaria en salud y el acceso a los servicios de esta, las barreras de acceso, y la participación en actividades educativas se estimaron mediante la razón de prevalencia (RP), con el uso del modelo de regresión logística multinivel en el software R. Un 89,5% de los individuos informó de acceso a servicios de atención primaria en salud, no existiendo diferencias estadísticamente significativas entre este tipo de acceso y el área de cobertura de la ESF. No sólo entre individuos residentes en áreas cubiertas por la ESF se verificó un mayor acceso a las acciones de prevención de enfermedades y promoción de la salud (RP = 3,0; IC95%: 1,68-5,34), sino también una menor probabilidad de que la atención se produzca el mismo día en el que se fija la consulta (RP = 0,60; IC95%: 0,48-0,74) y una menor disponibilidad de transporte colectivo (RP = 0,59; IC95%: 0,39-0,90). Los datos de este estudio apuntaron una elevada prevalencia de acceso a los servicios de la atención primaria en salud entre los adolescentes y adultos jóvenes. A pesar de que no se hayan observado diferencias de acceso entre las áreas con cobertura de la ESF, la mayor participación de estos individuos en actividades de prevención y promoción de la salud refuerza la importancia de esta estrategia en el ámbito del SUS.

Indicators of Abdominal Adiposity and Carotid Intima-Media Thickness: Results from the Longitudinal Study of Adult Health (ELSA-Brazil).

BACKGROUND: Abdominal adiposity is a risk factor for cardiovascular disease. OBJECTIVE: To determine the magnitude of the association between abdominal adiposity, according to five different indicators, and the carotid intima-media thickness (CIMT). METHODS: Data from 8,449 participants aged 35 to 74 years from the ELSA-Brazil study were used. The effect of waist circumference (WC), waist-to-hip ratio (WHR), conicity index (C index), lipid accumulation product (LAP) and visceral adiposity index (VAI) on CIMT were evaluated. Data were stratified by gender and analyzed using multivariate linear and logistic regressions. A significance level of 5% was considered. RESULTS: Participants with CIMT > P75 showed a higher frequency of abdominal adiposity (men >72% and women >66%) compared to those with CIMT < P75. Abdominal adiposity was associated with the mean CIMT, mainly through WC in men (0.04; 95%CI: 0.033; 0.058). The abdominal adiposity identified by the WC, WHR, LAP, and VAI indicators in women showed an effect of 0.02 mm on the CIMT (WC: 0.025, 95%CI: 0.016, 0.035; WHR: 0.026, 95%CI: 0.016, 0.035; LAP: 0.024, 95%CI: 0.014; 0.034; VAI: 0.020, 95%CI: 0.010, 0.031). In the multiple logistic regression, the abdominal adiposity diagnosed by WC showed an important effect on the CIMT in both genders (men: OR = 1.47, 95%CI: 1.22-1.77, women: OR = 1.38; 95%CI: 1.17-1.64). CONCLUSION: Abdominal adiposity, identified through WC, WHR, LAP, and VAI, was associated with CIMT in both genders, mainly for the traditional anthropometric indicator, WC.

Highly Accurate Chimeric Proteins for the Serological Diagnosis of Chronic Chagas Disease: A Latent Class Analysis.

The existence of an imperfect reference standard presents complications when evaluating the unbiased performance of novel diagnostic techniques. This is especially true in the absence of a gold standard, as is the case in chronic Chagas disease (CD) diagnosis. To circumvent this constraint, we elected to use latent class analysis (LCA). Previously, our group demonstrated the high performance of four Trypanosoma cruzi-chimeric proteins (Molecular Biology Institute of Paraná [IBMP]-8.1, -8.2, -8.3, and -8.4) for CD diagnosis using several distinct immunoassays. Although commercial tests had previously been established as a reference standard, the diagnostic performance of these chimeric antigens could present bias because these tests fail to produce 100% accurate results. Thus, we used LCA to assess the performance of these IBMP chimeric antigens in chronic CD diagnosis. Using the LCA model as a gold standard, sensitivity and specificity values ranged from 93.5% to 99.4% and 99.6% to 100%, respectively. The accuracy values were 96.2% for IBMP-8.2, approximately 98% for IBMP-8.1 and IBMP-8.3, and nearly 100% for IBMP-8.4. For IBMP-8.1 and IBMP-8.2, higher positive predictive values were associated with increases in hypothetical prevalence. Similarly, higher hypothetical prevalence resulted in lower negative predictive values for IBMP-8.1, IBMP-8.2, and IBMP-8.3. In addition, samples with serodiscordant results from commercial serological tests were analyzed using LCA. Molecular Biology Institute of Paraná -8.1 demonstrated potential for use in confirmatory testing with regard to samples with inconsistent results. Moreover, our findings further confirmed the remarkable performance of the IBMP-8.4 antigen to diagnose chronic CD in both endemic and non-endemic areas.

Patterns of metabolic syndrome and associated factors in women from the ELSA-Brasil: a latent class analysis approach / Padrões de síndrome metabólica e fatores associados em mulheres do ELSA-Brasil: uma abordagem com análise de classes latentes / Patrones del síndrome metabólico y factores asociados en mujeres del ELSA-Brasil: un enfoque con análisis de clases latentes

Abstract: This study aimed to identify patterns of metabolic syndrome among women and estimate their prevalence and relationship with sociodemographic and biological characteristics. In total, 5,836 women were evaluated using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Patterns of metabolic syndrome were defined via latent class analysis, using the following metabolic abnormalities as indicators: abdominal obesity, hyperglycemia, hypertension, hypertriglyceridemia, and reduced HDL cholesterol. The relationship between these patterns and individual characteristics was assessed using latent class analysis with covariates. Three patterns of metabolic syndrome were identified: high metabolic expression, moderate metabolic expression, and low metabolic expression. The first two patterns represented most women (53.8%) in the study. Women with complete primary or secondary education and belonging to lower social classes were more likely to have higher metabolic expression. Black and mixed-race women were more likely to have moderate metabolic expression. Menopausal women aged 50 years and older were more often classified into patterns of greater health risk. This study addressed the heterogeneous nature of metabolic syndrome, identifying three distinct profiles for the syndrome among women. The combination of abdominal obesity, hyperglycemia, and hypertension represents the main metabolic profile found among ELSA-Brasil participants. Sociodemographic and biological factors were important predictors of patterns of metabolic syndrome.

Resumo: O objetivo foi identificar padrões de síndrome metabólica em mulheres, estimar suas prevalências e relações com características sociodemográficas e biológicas. Este estudo examinou 5.836 mulheres utilizando dados da linha de base do Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil). Os padrões de síndrome metabólica foram definidos por meio de análise de classe latente, usando as seguintes anormalidades metabólicas como indicadores: obesidade abdominal, hiperglicemia, hipertensão, hipertrigliceridemia e colesterol HDL reduzido. As relações entre os padrões de síndrome metabólica e as características individuais foram avaliadas por meio da análise de classes latentes com covariáveis. Foram identificados três padrões de síndrome metabólica, denominados "alta expressão metabólica", "expressão metabólica moderada" e "baixa expressão metabólica". Os dois primeiros padrões representaram a maioria (53,8%) das mulheres do estudo. As mulheres com nível de escolaridade primário ou secundário e pertencentes à classe social baixa tiveram maior chance de apresentar maior expressão metabólica. Negros e pardos tiveram maior chance de apresentar "expressão metabólica moderada". Mulheres na menopausa com 50 anos ou mais apresentaram maior chance de ter padrões de maior risco à saúde. Este estudo abordou a natureza heterogênea da síndrome metabólica, identificando três perfis distintos para a síndrome entre as mulheres. A combinação de obesidade abdominal, hiperglicemia e hipertensão representa o principal perfil metabólico encontrado entre os participantes do ELSA-Brasil. Fatores sociodemográficos e biológicos foram importantes preditores para os padrões de síndrome metabólica.

Resumen: El objetivo fue identificar patrones del síndrome metabólico en mujeres, estimar sus prevalencias y relaciones con características sociodemográficas y biológicas. Este estudio examinó 5.836 mujeres utilizando datos de la línea de base del Estudio Longitudinal de Salud del Adulto (ELSA-Brasil). Los patrones de síndrome metabólico se definieron a través del análisis de clase latente, utilizando las siguientes anormalidades metabólicas como indicadores: obesidad abdominal, hiperglucemia, hipertensión, hipertrigliceridemia y colesterol HDL reducido. Las relaciones entre los patrones de síndrome metabólico y las características individuales se evaluaron a través del análisis de clases latentes con covariables. Se identificaron tres patrones de síndrome metabólico, denominados "alta expresión metabólica", "expresión metabólica moderada" y "baja expresión metabólica". Los primeros dos patrones representan la mayoría (el 53,8%) de las mujeres del estudio. Las mujeres que tenían un nivel de escolaridad primario o secundario y que pertenecían a la clase social baja tuvieron una mayor probabilidad de presentar una expresión metabólica más alta. Los negros y pardos tuvieron una probabilidad más alta de presentar "expresión metabólica moderada". Las mujeres en la menopausia que tenían 50 años o más presentaron una probabilidad más alta de tener patrones de mayor riesgo para la salud. Este estudio abordó la naturaleza heterogénea del síndrome metabólico, identificando tres perfiles diferentes para el síndrome entre las mujeres. La combinación de obesidad abdominal, hiperglucemia e hipertensión representa el principal perfil metabólico encontrado entre los participantes del ELSA-Brasil. Factores sociodemográficos y biológicos fueron importantes predictores para los patrones de síndrome metabólico.

The mass use of deltamethrin collars to control and prevent canine visceral leishmaniasis: A field effectiveness study in a highly endemic area.

BACKGROUND: Visceral leishmaniasis (VL) is a zoonosis of great importance. Limitations in current VL control measures compromise efficacy, indicating the need to implement new strategies. The aim of this study was to evaluate the effectiveness of the mass use of deltamethrin-impregnated collars in dogs as a public health measure to control and prevent canine visceral leishmaniasis (CVL). METHODOLOGY: An interventional study was implemented in two endemic areas in the district of Monte Gordo (Bahia-Brazil): an intervention area, in which VL seronegative dogs were collared, and a control area in which only conventional CVL control measures were applied. At baseline, seropositive dogs were removed and seronegative dogs were included. Dogs were then reevaluated every 7-8 months for almost two years. At each time point, dogs in the intervention area that remained seronegative received new collars and newly identified seronegative dogs were included and collared. The local zoonosis control authorities were notified of any dogs that tested seropositive in both areas, which were subsequently marked for euthanasia as mandated by the Brazilian Ministry of Health. PRINCIPAL FINDINGS: In the first serological survey, seroprevalence was similar in both areas. At the second evaluation, significant reductions in seroprevalence were seen in both areas, while seroprevalence in the intervention area reduced to 6.0% during the final evaluation versus an increase of 11.0% in the control area. This significant increase and the estimated relative risk (RR = 0.55) indicated protection against CVL in the intervention area. Although CVL incidence did not differ significantly between the areas, an increased tendency was observed in the control area, which could be due to low seroconversion rates throughout the study or a high loss to follow-up. CONCLUSIONS/SIGNIFICANCE: Although our evaluation of the effectiveness of deltamethrin-impregnated collars as a community-wide public health control measure was inconclusive, this measure likely provides protection over time. In endemic areas of Brazil, this strategy represents an operational challenge for local zoonosis control authorities, indicating the need for adjustments, including improved collar design.

What Factors Explain Bicycling and Walking for Commuting by ELSA-Brasil Participants?

PURPOSE: To analyze the factors associated with commuting by bicycling and walking in adult participants from ELSA-Brasil (Longitudinal Study of Adult Health). DESIGN: Cross-sectional. SETTING: Six teaching/research institutions throughout Brazil. PARTICIPANTS: A total of 15 105 civil servants. MEASURES: Commuting by bicycling and walking was analyzed using the long-form International Physical Activity Questionnaire. ANALYSIS: A hierarchical model containing possible factors associated with commuting by bicycling and walking was constructed. Crude and adjusted odds ratios were calculated using multinomial logistic regression. RESULTS: Considering the 2 forms of commuting, 66% of the participants were being considered inactive or insufficiently active. In women, being "heavier," feeling unsafe practicing physical activity, and being a former smoker were factors negatively associated with commuting by bicycling and walking. In men, active commuting was less common among those who were overweight or had abdominal obesity, those with a negative perception of safety, and those reporting that there was nowhere suitable in the neighborhood to practice physical activity. CONCLUSION: Obesity and negative perceptions in the neighborhood are associated with inactive or insufficiently active commuting. The relevance of this finding for public health is reinforce developing policies aimed at promoting health in Brazil and in other countries with similar characteristics.

Características percebidas da vizinhança e a prática de atividade física entre adolescentes e adultos jovens: um modelo com respostas distais / Perceived neighborhood characteristics and practice of physical activity among adolescents and young adults: a model with distal outcomes / Características percibidas del vecindario y la práctica de actividad física entre adolescentes y adultos jóvenes: un modelo con respuestas distales

Os objetivos do estudo foram identificar perfis de vizinhança percebidos por adolescentes e adultos jovens, e estimar sua associação com a realização de atividade física global e de lazer. Utilizaram-se dados de 1.637 indivíduos entre 15 e 24 anos, de um estudo transversal, com amostragem por conglomerados, de uma cidade do Estado da Bahia, Brasil, em 2011. A atividade física foi mensurada pelo International Physical Activity Questionnaire (IPAQ), versão curta, além de questão sobre atividade no lazer. A percepção de características do ambiente físico e social da vizinhança se baseou em escala com 14 questões. Perfis de vizinhança foram definidos por meio de análise de classes latentes (LCA), e a estimação dos seus efeitos na atividade física usou o modelo com respostas distais. A análise de perfil latente resultou em três padrões de vizinhança, descritos como "urbana, sociável e favorável à atividade física - classe 1" (39,6%); "sociável e segura - classe 2" (24,4%); e "insegura, de baixa sociabilidade - classe 3" (36%). Os indivíduos pertencentes à "classe 1" apresentaram maior probabilidade de se exercitar (56,4%), enquanto, para as classes 2 e 3, estes percentuais corresponderam a 46,3% e 42,8%, respectivamente. Associação estatisticamente significante foi identificada apenas na classe "urbana, sociável e favorável à atividade física", cuja chance de realizar atividade de lazer foi de 72% (OR = 1,72; IC95%: 1,29-2,29). Bairros com atributos favoráveis à prática de atividade física e a existência de elementos de urbanização aumentam a chance do comportamento ativo no lazer entre os adolescentes e adultos jovens. O uso de LCA e do modelo com repostas distais é promissor e inovador na abordagem sobre vizinhança.

This study aimed to identify neighborhood profiles perceived by adolescents and young adults and estimate their association with global and leisure-time physical activity. Data from 1,637 individuals aged 15 to 24 years were taken from a cross-sectional study with cluster sampling, conducted in a city in the State of Bahia, Brazil, in 2011. Physical activity was measured using the International Physical Activity Questionnaire (IPAQ), short version, in addition to a question about leisure activities. The perception of characteristics of the physical and social environment of the neighborhood was based on a scale with 14 questions. Neighborhood profiles were defined through latent class analysis (LCA), and the estimation of their effects on physical activity used a model with distal outcomes. The latent profile analysis resulted in three neighborhood patterns, described as "urban, sociable, and favorable to physical activity - class 1" (39.6%); "sociable and safe - class 2" (24.4%), "insecure, low sociability - class 3" (36%). Individuals belonging to "class 1" showed the highest probability to exercise (56.4%), while for classes 2 and 3 these percentages corresponded to 46.3% and 42.8%, respectively. A statistically significant association was identified only in the "urban, sociable and favorable to physical activity" class, whose chance of performing leisure activities was 72% (OR = 1.72; 95%CI: 1.29-2.29). Neighborhoods with attributes that favor the practice of physical activity and the existence of urbanization elements increase the chance of active leisure behavior among adolescents and young adults. The use of LCA and the model with distal outcomes are promising and innovative in neighborhood approaches.

Los objetivos del estudio fueron identificar los perfiles de vecindario percibidos por los adolescentes y los adultos jóvenes y estimar su asociación con la realización de actividad física global y de ocio. Se utilizaron datos de 1.637 individuos entre 15 y 24 años, procedentes de un estudio transversal, con muestreo por conglomerados, de una ciudad del estado de Bahia, Brasil, en 2011. La actividad física se midió mediante el International Physical Activity Questionnaire (IPAQ), versión corta, además de una pregunta sobre actividad en el ocio. La percepción de las características del entorno físico y social del vecindario se basó en una escala con 14 preguntas. Los perfiles de la vecindad se definieron a través del análisis de clase latente (ACL), y la estimación de sus efectos sobre la actividad física utilizó el modelo con respuestas distales. El análisis de perfil latente dio como resultado tres patrones de vecindario, descritos como "urbano, sociable y favorable a la actividad física - clase 1" (39,6 %); "sociable y seguro - clase 2" (24,4 %), "inseguro, de baja sociabilidad - clase 3" (36%). Los individuos pertenecientes a la "clase 1" presentaron la mayor probabilidad de hacer ejercicio (56,4 %), mientras que para las clases 2 y 3 estos porcentajes correspondieron a 46,3 % y 42,8 %, respectivamente. Solamente se identificó una asociación estadísticamente significativa en la clase "urbana, sociable y favorable a la actividad física", cuya probabilidad de realizar actividad de ocio fue de 72 % (OR = 1,72; IC95%: 1,29-2,29). Los barrios con atributos favorables para la actividad física y la existencia de elementos de urbanización aumentan la posibilidad de un comportamiento activo en el ocio entre los adolescentes y los adultos jóvenes. El uso de ACL y el modelo con respuestas distales son enfoques prometedores e innovadores para la vecindad.

Ideal cardiovascular health at ELSA-Brasil: non-additivity effects of gender, race, and schooling by using additive and multiplicative interactions / Saúde cardiovascular ideal na ELSA-Brasil: efeitos não-aditivos de gênero, raça e escolaridade através do uso de interações aditivas e multiplicativas / Salud cardiovascular ideal en ELSA-Brasil: efectos no aditivos de género, raza y educación a través del uso de interacciones aditivas y multiplicativas

This study aims to assess the non-additivity effects of gender, race, and schooling on ideal cardiovascular health among participants of the Brazilian Longitudinal Study of Adult Health - ELSA-Brasil. This is a cross-sectional study using data from the baseline of ELSA-Brasil, conducted from 2008 to 2010. The American Heart Association defined a score of ideal cardiovascular health (ICH) as the sum of indicators for the presence of seven favorable health factors and behaviors: non-smoking, ideal body mass index, physical activity and healthy diet, adequate levels of total cholesterol, normal blood pressure, and absence of diabetes mellitus. Multiplicative and additive interactions between gender, race, and schooling were assessed using the Poisson regression model to discuss intersectionality. The mean cardiovascular health score was 2.49 (SD = 1.31). This study showed a positive interaction between gender and schooling (women with high school and higher education) in both additive and multiplicative scales for the score of ideal cardiovascular health. We observed a trend towards higher mean values of cardiovascular health for increased schooling, with a marked difference among women. The lowest cardiovascular health scores observed reinforce the importance of understanding the psychosocial experiences that influence health attitudes, access to health care, and healthy lifestyle choices, which affect ICH, to reduce inequities in health and propose more adequate public policies that assist and prevent cardiovascular diseases.

Este estudo visa avaliar a não-aditividade dos efeitos de gênero, raça e escolaridade na saúde cardiovascular ideal entre os participantes do Estudo Longitudinal de Saúde do Adulto - ELSA-Brasil. Trata-se de um estudo transversal utilizando dados da linha de base do ELSA-Brasil, realizado entre 2008-2010. A Associação Americana do Coração definiu a pontuação de saúde cardiovascular ideal (ICH) como a soma dos indicadores da presença de sete fatores e comportamentos favoráveis à saúde: não fumante, índice de massa corporal ideal, atividade física e dieta saudável, níveis adequados de colesterol total, pressão arterial normal e ausência de diabetes mellitus. Interações multiplicativas e aditivas entre gênero, raça e escolaridade foram avaliadas usando o modelo de Poisson, como uma abordagem para discutir a interseccionalidade. A pontuação média de saúde cardiovascular foi de 2,49 (DP = 1,31). Este estudo encontrou uma interação positiva entre gênero e escolaridade (mulheres com Ensino Médio e Superior), tanto na escala aditiva quanto na escala multiplicativa, para a pontuação de saúde cardiovascular ideal. Houve tendência para maiores valores médios de saúde cardiovascular com o aumento da escolaridade, com diferença acentuada entre as mulheres. As pontuações mais baixas de saúde cardiovascular observadas reforçam a importância de compreender-se as experiências psicossociais que influenciam as atitudes em relação aos serviços de saúde, ao acesso à saúde e às escolhas de estilo de vida saudável, que afetam a ICH, para reduzir as desigualdades em saúde e propor políticas públicas mais adequadas como uma estratégia de assistência e prevenção das doenças cardiovasculares.

Este estudio tiene como objetivo evaluar los efectos no aditivos de género, raza y educación en la salud cardiovascular ideal entre los participantes del Estudio Longitudinal de Salud del Adulto -ELSA-Brasil. Se trata de un estudio transversal realizado a partir de datos de línea de base de ELSA-Brasil entre 2008-2010. La Asociación Americana del Corazón definió el puntaje ideal de salud cardiovascular (ICH) como la suma de indicadores de la presencia de siete factores y comportamientos favorables a la salud: no fumador, índice de masa corporal ideal, actividad física y alimentación saludable, niveles adecuados de colesterol total, presión arterial normal y ausencia de diabetes mellitus. Las interacciones multiplicativas y aditivas entre género, raza y educación se evaluaron utilizando el modelo de Poisson como un enfoque para discutir la interseccionalidad. La puntuación media de salud cardiovascular fue de 2,49 (DE = 1,31). Este estudio encontró una interacción positiva entre el género y la educación (mujeres con educación secundaria y universitaria), tanto en la escala aditiva como en la escala multiplicativa, para puntajes ideales de salud cardiovascular. Hubo una tendencia a valores medios más altos de salud cardiovascular conforme aumenta el nivel de educación, con una marcada diferencia entre las mujeres. Los puntajes más bajos de salud cardiovascular refuerzan la importancia de comprender las experiencias psicosociales que influyen en las actitudes hacia la salud, el acceso a la salud y la elección de un estilo de vida saludable, que inciden en el ICH, para reducir las desigualdades en salud y proponer políticas públicas más adecuadas como estrategia de asistencia y prevención de enfermedades cardiovasculares.

Performance evaluation of tuberculosis control in Brazilian municipalities / Avaliação de desempenho do controle da tuberculose em municípios brasileiros

ABSTRACT OBJECTIVE To evaluate the performance of tuberculosis control in Brazilian municipalities. METHODS This is an ecological study on Brazilian municipalities that notified at least four new cases of tuberculosis, with a minimum of one new case of pulmonary tuberculosis between 2015 and 2018. The municipalities were stratified according to the population in < 50 thousand, 50-100 thousand, 100-300 thousand, and > 300 thousand inhabitants, and the k-means method was used to group them within each population range according to the performance of six indicators of the disease. RESULTS A total of 2,845 Brazilian municipalities were included, comprising 98.5% (208,007/211,174) of new tuberculosis cases in the period. For each population range, three groups (A, B, and C) of municipalities were identified according to the performance of the indicators: A, the most satisfactory; B, the intermediates; and C, the least satisfactory. Municipalities in group A with < 100 thousand inhabitants presented results above the targets for laboratory confirmation (≥ 72%), abandonment (≤ 5%), and cure (≥ 90%), and comprised 2% of new cases of the disease. Conversely, municipalities of groups B and C presented at least five indicators with results below the targets - HIV testing (< 100%), contact investigation (< 90%), directly observed therapy (< 90%), abandonment (> 5%), and cure (< 90%) -, and corresponded to 66.7% of new cases of tuberculosis. In group C of municipalities with > 300 thousand inhabitants, which included 19 of the 27 capitals and 43.1% of new cases of tuberculosis, the lowest percentages of contact investigation (mean = 56.4%) and directly observed therapy (mean = 15.4%) were verified, in addition to high abandonment (mean = 13.9%) and low coverage of primary health care (mean = 66.0%). CONCLUSIONS Most new cases of tuberculosis occurred in municipalities with unsatisfactory performance for disease control. Expanding the coverage of primary health care in these places can reduce abandonment and increase the contact investigation and directly observed therapy.

RESUMO OBJETIVO Avaliar o desempenho no controle da tuberculose dos municípios brasileiros. MÉTODOS Estudo ecológico com municípios brasileiros que notificaram pelo menos quatro casos novos de tuberculose, com no mínimo um caso novo de tuberculose pulmonar entre 2015 e 2018. Os municípios foram estratificados de acordo com a população em < 50 mil, 50-100 mil, 100-300 mil e > 300 mil habitantes e foi utilizado o método k-médias para agrupá-los dentro de cada faixa populacional segundo desempenho de seis indicadores da doença. RESULTADOS Foram incluídos 2.845 municípios brasileiros abrangendo 98,5% (208.007/211.174) dos casos novos de tuberculose do período. Para cada faixa populacional identificou-se três grupos (A, B e C) de municípios segundo desempenho dos indicadores: A os mais satisfatórios, B os intermediários e C os menos satisfatórios. Municípios do grupo A com < 100 mil habitantes apresentaram resultados acima das metas para confirmação laboratorial (≥ 72%), abandono (≤ 5%) e cura (≥ 90%), e abrangeram 2% dos casos novos da doença. Por outro lado, os municípios dos grupos B e C apresentaram pelo menos cinco indicadores com resultados abaixo das metas - testagem HIV (< 100%), exame de contatos (< 90%), tratamento diretamente observado (< 90%), abandono (> 5%) e cura (< 90%) -, e corresponderam a 66,7% dos casos novos de tuberculose. Já no grupo C dos municípios com > 300 mil habitantes, que incluiu 19 das 27 capitais e 43,1% dos casos novos de tuberculose, encontrou-se os menores percentuais de exames de contatos (média = 56,4%) e tratamento diretamente observado (média = 15,4%), elevado abandono (média = 13,9%) e baixa cobertura da atenção básica (média = 66,0%). CONCLUSÕES Grande parte dos casos novos de tuberculose ocorreu em municípios com desempenho insatisfatório para o controle da doença, onde expandir a cobertura da atenção básica pode reduzir o abandono e elevar o exame de contatos e tratamento diretamente observado.

The Rapid Test Based on Leishmania infantum Chimeric rK28 Protein Improves the Diagnosis of Canine Visceral Leishmaniasis by Reducing the Detection of False-Positive Dogs.

Visceral Leishmaniasis (VL) has spread to many urban centers worldwide. Dogs are considered the main reservoir of VL, because canine cases often precede the occurrence of human cases. Detection and euthanasia of serologically positive dogs is one of the primary VL control measures utilized in some countries, including Brazil. Using accurate diagnostic tests can minimize one undesirable consequence of this measure, culling false-positive dogs, and reduce the maintenance of false-negative dogs in endemic areas. In December 2011, the Brazilian Ministry of Health replaced the ELISA (EIE CVL) screening method and Indirect Immunofluorescence Test (IFI CVL) confirmatory method with a new protocol using the rapid DPP CVL screening test and EIE CVL confirmatory test. A study of diagnostic accuracy of these two protocols was done by comparing their performance using serum samples collected from a random sample of 780 dogs in an endemic area of VL. All samples were evaluated by culture and real time PCR; 766 out of the 780 dogs were tested using the previous protocol (IFI CVL + EIE CVL) and all 780 were tested using the current protocol (DPP CVL + EIE CVL). Performances of both diagnostic protocols were evaluated using a latent class variable as the gold standard. The current protocol had a higher specificity (0.98 vs. 0.95) and PPV (0.83 vs. 0.70) than the previous protocol, although sensitivity of these two protocols was similar (0.73). When tested using sera from asymptomatic animals, the current protocol had a much higher PPV (0.63 vs. 0.40) than the previous protocol (although the sensitivity of either protocol was the same, 0.71). Considering a range of theoretical CVL prevalences, the projected PPVs were higher for the current protocol than for the previous protocol for each theoretical prevalence value. The findings presented herein show that the current protocol performed better than previous protocol primarily by reducing false-positive results.

Social position and anthropometric status among adults in the ELSA-Brasil study: a latent class analysis / Posição social e estado antropométrico entre adultos no estudo ELSA-Brasil: uma análise de classes latentes / Posición social y estatus antropométrico entre adultos en el estudio ELSA-Brasil: un análisis de clase latente

Abstract: The objective of the present study was to evaluate the association between social position and anthropometric status in women and men Brazilian adult. This was a cross-sectional study that used baseline data collected from 2008 to 2010 for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil, in Portuguese), in the six major Brazilian state capital cities. A total of 15,105 active and retired civil servants aged from 35 to 74 years. Two latent variables were defined by latent class analysis, social position and anthropometric status. Both constructs and the analyses were separately evaluated by sex. Associations were assessed using multivariate logistic regression analysis with adjustment for age, self-reported skin color/race, and marital status. Around 44% of the women and 26% of the men were classified as overweight or obese. Social position tended to be lower in women (43.2%) and higher among men (40.4%). Heavier women were more likely to be black and brown-skinned, whereas slimmer women were more likely to be white. After adjustment, women's weight increased as social position decreased (OR = 1.52; 95%CI: 1.36-1.70), whereas in men weight decreased as social position decreased (OR = 0.87; 95%CI: 0.76-0.99). Social position affected the anthropometric status of women and men differently, with body patterns also being affected by ethnicity/skin color, showing the potentiality of taking the intersectional perspective when investigating the possible social determinants of the phenomenon.

Resumo: O objetivo do estudo foi avaliar a associação entre posição social e o estado antropométrico em brasileiros adultos de ambos os sexos. O estudo transversal usou dados coletados entre 2008 e 2010 pelo Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil), nas seis maiores capitais brasileiras. Um total de 15.105 funcionários públicos, ativos e aposentados, de ambos os sexos, entre 35 e 74 anos de idade. Duas variáveis latentes foram definidas pela análise de classes latentes: posição social e estado antropométrico. Os construtos e análises foram avaliados separadamente por sexo. As associações foram avaliadas com o uso de análise de regressão logística multivariada, ajustada para idade, cor/raça e estado civil. Em torno de 44% das mulheres e 26% dos homens foram classificados com sobrepeso ou obesidade. A posição social tendia a ser mais baixa nas mulheres (43,2%) e mais alta nos homens (40,4%). Houve uma proporção maior de mulheres com sobrepeso ou obesidade entre as pretas e pardas, e proporção maior de mulheres magras entre as brancas. Nas mulheres, após ajustes, o peso aumentava na medida em que a posição social diminuía (OR = 1,52; IC95%: 1,36-1,70), enquanto nos homens o peso diminuía junto com a diminuição da posição social (OR = 0,87; IC95%: 0,76-0,99). A posição social afetou de maneira diferente o estado antropométrico de mulheres e homens, com perfis corporais afetados também pela raça/cor da pele, indicando o potencial de levar em conta a perspectiva interseccional ao investigar os possíveis determinantes sociais do fenômeno.

Resumen: El objetivo de este estudio fue evaluar la asociación entre posición social y estatus antropométrico de adultos brasileños de ambos sexos. Fue un estudio transversal, realizado usando datos de referencia recogidos entre 2008 y 2010, del Estudio Longitudinal Brasileño de Salud en Adultos (ELSA-Brasil), llevado a cabo en seis de las mayores capitales de estado brasileñas. Un total de 15.105 activos y jubilados, mujeres y hombres funcionarios públicos de 35 a 74 años de edad. Se definieron dos variables latentes mediante análisis de clases latentes: posición social y estatus antropométrico. Ambos constructos y análisis fueron evaluados separadamente por sexo. Las asociaciones fueron evaluadas usando una regresión logística multivariada con ajuste por edad, color de piel/raza autoinformado y estatus marital. Alrededor de un 44% de las mujeres y un 26% de los hombres fueron clasificados como con sobrepeso u obesos. La posición social tendió a ser más baja en mujeres (43,2%) y más alta entre hombres (40,4%). Las mujeres con más peso tenían más probabilidad de ser negras y mulatas/mestizas y las mujeres más delgadas tenían más probabilidad de ser blancas. En mujeres, tras el ajuste, se incrementó más el peso cuanto mayor decrecía la posición social (OR = 1,52; IC95%: 1,36-1,70), mientras en hombres el peso decrecía al igual que la posición social (OR = 0,87; IC95%: 0,76-0,99). La posición social afectó diferentemente al estatus antropométrico de mujeres y hombres, con los patrones corporales también estando afectados por etnicidad/color de piel, mostrando su potencialidad tomando en consideración la perspectiva transversal, cuando se está investigando los posibles determinantes sociales del fenómeno.

Programa Mais Médicos: contexto de implantação e efeito no provimento de médicos na atenção primária à saúde no Brasil, 2008 a 2016 / More Doctors Program: context of implementation and effect on the provision of primary health care physicians in Brazil, 2008-2016 / Programa Mais Médicos: contexto de implementación y efecto en la dotación de médicos de atención primaria de salud en Brasil, 2008-2016

Objetivo. Caracterizar os municípios brasileiros que compunham os perfis prioritários para implantação do Programa Mais Médicos (PMM) e avaliar o efeito do programa no provimento emergencial de médicos na atenção primária à saúde (APS) no Brasil segundo contexto de implantação. Métodos. Estudo de séries temporais interrompidas, que considerou como desfecho as taxas de médicos de APS/10 000 habitantes no Brasil e nos contextos de implantação do PMM. Para essa análise de série temporal, foram coletados dados mensais de janeiro de 2008 a dezembro de 2016. O início da intervenção foi estabelecido no mês de julho de 2013, data da assinatura da medida provisória que criou o PMM. Os municípios foram caracterizados segundo aspectos demográficos, socioeconômicos, serviços de saúde e distribuição de médicos. Resultados. A criação do PMM resultou em incremento na taxa de médicos de APS em todos os perfis prioritários para a implantação do programa, com destaque para municípios com mais de 20% dos habitantes vivendo em situação de pobreza. Além disso, o estudo demonstrou diferenças marcantes entre os municípios brasileiros em aspectos socioeconômicos, na organização de serviços de saúde e na disponibilidade de médicos na APS, inclusive dentro de um mesmo contexto de implantação do PMM. Conclusões. O PMM tem contribuído para reduzir a escassez e a má distribuição de médicos na APS no Brasil, reduzindo as inequidades de acesso. Desse modo, foi bem-sucedido em seu eixo de provimento emergencial, tornando-se uma importante estratégia de fortalecimento da APS e do Sistema Único de Saúde.(AU)

Objective. To characterize the Brazilian municipalities in each More Doctors Program (MDP) priority profile and to assess the effect of the program on the emergency supply of primary care physicians in Brazil according to implementation context. Method. An interrupted time-series analysis (ITSA) was performed, considering as outcome the rate of primary care physicians/10 000 inhabitants in Brazil and within each MDP implementation context. Monthly data were collected from January 2008 to December 2016. The intervention was considered to have started in July 2013, when the MDP was officially created. The municipalities were characterized according to demographic, socioeconomic, health care service, and physician distribution variables. Results. Establishment of the MDP was associated with increased rate of primary care physicians in all priority profiles, especially in municipalities in which at least 20% of the population lived in poverty. Furthermore, the study showed significant differences among Brazilian municipalities in socioeconomic aspects, health care service organization, and availability of primary care physicians, even within the same MDP implementation context. Conclusion. The MDP has contributed to reduce the shortage and improve the distribution of primary care physicians in Brazil, thus reducing inequalities in access to services. Consequently, the MDP was successful in its emergency supply of physicians, having become an important strategy to strengthen primary health care and the Brazilian Unified Health System.(AU)

Objetivo. Caracterizar los municipios brasileños representativos de los perfiles prioritarios para la implementación del programa Mais Médicos (PMM) y evaluar el efecto del programa en la dotación de médicos de atención primaria de salud (APS) en situaciones de emergencia en Brasil, según el contexto de implementación. Métodos. Se realizó un análisis de series cronológicas interrumpidas, en el cual se consideraron como resultado las tasas de dotación de médicos de APS por cada 10 000 habitantes en Brasil y en el contexto de implementación del PMM. Para dicho análisis, se recolectaron datos mensuales desde enero del 2008 hasta diciembre del 2016. Se determinó que la intervención comenzó en el mes de julio del 2013, fecha de la firma de la medida provisional en virtud de la cual se creó el PMM. Los municipios se caracterizaron según sus características demográficas y socioeconómicas, los servicios de salud y la distribución de los médicos en cada uno. Resultados. La creación del PMM redundó en un incremento de la tasa de dotación de médicos de APS en todos los perfiles prioritarios para la implementación del programa, con hincapié en los municipios donde más de 20% de los habitantes se encontraban en situación de pobreza. Además, el análisis demostró que había notables diferencias entre los municipios brasileños en cuanto al aspecto socioeconómico, a la organización de los servicios de salud y a la disponibilidad de médicos de APS, incluso dentro del mismo contexto de implementación del PMM. Conclusión. El PMM ha contribuido a reducir la escasez y la mala distribución de los médicos de APS en Brasil, con lo cual ha disminuido la inequidad del acceso a los servicios. En ese sentido, tuvo éxito en su eje de dotación de médicos en situaciones de emergencia, hecho que lo convirtió en una importante estrategia de fortalecimiento de la APS y del Sistema Único de Salud.(AU)