RESUMO
In previous reports, psoriasis was associated with an increased rate of coronary artery disease. These data has not been investigated in our population. We performed a cross-sectional study analyzing data from electronic medical records of a health system in Buenos Aires. We included all patients older than 18 years diagnosed with psoriasis between January 1, 2003 and July 31, 2011 and compared them with a control group. Controls were selected randomly by strata of age and sex from the same health system in a 2:1 ratio. We determined the prevalence of cardiovascular risk factors and coronary heart disease. We analyzed the association between psoriasis and coronary artery disease by both univariate and multivariate analyzes. In total, 3 833 subjects were included (1 286 with psoriasis and 2 547 controls). The prevalence of hypertension (50% vs. 38%, p < 0.001), smoking (25% vs. 17%, p < 0.001), diabetes (12% vs. 8%, p < 0.001) and coronary artery disease (4.98% vs. 3.06%, p = 0.003) were higher in the psoriasis group compared to controls. Regardless age and the presence or absence of diabetes, hypertension or smoking, there was a significant association between coronary artery disease and psoriasis (OR 1.48, CI95% 1.04-2.11, p = 0.03). In conclusion, in this population of Buenos Aires, psoriasis patients had a higher prevalence of diabetes, hypertension, smoking, and coronary artery disease. The association between psoriasis and coronary artery disease was independent of the risk factors explored.
Assuntos
Doença da Artéria Coronariana/etiologia , Psoríase/complicações , Adulto , Idoso , Argentina/epidemiologia , Estudos de Casos e Controles , Doença da Artéria Coronariana/epidemiologia , Estudos Transversais , Complicações do Diabetes/epidemiologia , Registros Eletrônicos de Saúde , Feminino , Humanos , Hipertensão/complicações , Hipertensão/epidemiologia , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Prevalência , Psoríase/epidemiologia , Fatores de Risco , Distribuição por Sexo , Fumar/efeitos adversos , Fumar/epidemiologia , Estatísticas não ParamétricasRESUMO
Comunicaciones previas asociaron la psoriasis con la enfermedad coronaria. Desconocemos si en nuestro país o región existe dicha asociación. Se realizó un estudio transversal analizando los datos de la historia clínica electrónica de un sistema de salud de Buenos Aires. Analizamos todos los pacientes mayores de 18 años con diagnóstico de psoriasis entre el 1 de enero de 2003 y el 31 de julio de 2011 y los comparamos con un grupo control, en una relación 2:1, obtenido en forma aleatoria del mismo sistema de salud, apareados por edad y sexo. Determinamos la prevalencia de los factores de riesgo cardiovascular y de enfermedad coronaria. Analizamos la asociación entre la enfermedad coronaria y la psoriasis mediante análisis uni y multivariado. Se incluyeron 3 833 sujetos (1 286 pacientes con psoriasis y 2 547 controles). La prevalencia de hipertensión arterial (50% vs. 38%, p < 0.001), tabaquismo (25% vs. 17%, p < 0.001), diabetes (12% vs. 8%, p < 0.001) y enfermedad coronaria (4.98% vs. 3.06%, p = 0.003) fue mayor en los sujetos con psoriasis en comparación con el grupo control. Independientemente de la edad, la presencia de diabetes, hipertensión arterial o tabaquismo, hubo una asociación significativa entre la enfermedad coronaria y la psoriasis (OR 1.48, IC95% 1.04-2.11, p = 0.03). En conclusión, en esta población de Buenos Aires, los pacientes con psoriasis tuvieron una mayor prevalencia de diabetes, hipertensión arterial, tabaquismo y enfermedad coronaria. La asociación entre la psoriasis y la enfermedad coronaria fue independiente de los factores de riesgo explorados.
In previous reports, psoriasis was associated with an increased rate of coronary artery disease. These data has not been investigated in our population. We performed a cross-sectional study analyzing data from electronic medical records of a health system in Buenos Aires. We included all patients older than 18 years diagnosed with psoriasis between January 1, 2003 and July 31, 2011 and compared them with a control group. Controls were selected randomly by strata of age and sex from the same health system in a 2:1 ratio. We determined the prevalence of cardiovascular risk factors and coronary heart disease. We analyzed the association between psoriasis and coronary artery disease by both univariate and multivariate analyzes. In total, 3 833 subjects were included (1 286 with psoriasis and 2 547 controls). The prevalence of hypertension (50% vs. 38%, p < 0.001), smoking (25% vs. 17%, p < 0.001), diabetes (12% vs. 8%, p < 0.001) and coronary artery disease (4.98% vs. 3.06%, p = 0.003) were higher in the psoriasis group compared to controls. Regardless age and the presence or absence of diabetes, hypertension or smoking, there was a significant association between coronary artery disease and psoriasis (OR 1.48, CI95% 1.04-2.11, p = 0.03). In conclusion, in this population of Buenos Aires, psoriasis patients had a higher prevalence of diabetes, hypertension, smoking, and coronary artery disease. The association between psoriasis and coronary artery disease was independent of the risk factors explored.