Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Thrombin cleavage of the hepatitis E virus polyprotein at multiple conserved locations is required for genome replication.

Pierce, Danielle M; Buchanan, Frazer J T; Macrae, Fraser L; Mills, Jake T; Cox, Abigail; Abualsaoud, Khadijah M; Ward, Joseph C; Ariëns, Robert A S; Harris, Mark; Stonehouse, Nicola J; Herod, Morgan R.

PLoS Pathog ; 19(7): e1011529, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-37478143

2.

Elimination of fibrin Î³-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi.

Duval, Cédric; Baranauskas, Adomas; Feller, Tímea; Ali, Majid; Cheah, Lih T; Yuldasheva, Nadira Y; Baker, Stephen R; McPherson, Helen R; Raslan, Zaher; Bailey, Marc A; Cubbon, Richard M; Connell, Simon D; Ajjan, Ramzi A; Philippou, Helen; Naseem, Khalid M; Ridger, Victoria C; Ariëns, Robert A S.

Proc Natl Acad Sci U S A ; 118(27)2021 07 06.

Artigo em Inglês | MEDLINE | ID: mdl-34183396

3.

Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer.

Slater, Alexandre; Di, Ying; Clark, Joanne C; Jooss, Natalie J; Martin, Eleyna M; Alenazy, Fawaz; Thomas, Mark R; Ariëns, Robert A S; Herr, Andrew B; Poulter, Natalie S; Emsley, Jonas; Watson, Steve P.

Blood ; 137(24): 3443-3453, 2021 06 17.

Artigo em Inglês | MEDLINE | ID: mdl-33512486

4.

The Role of Fibrin(ogen) in Wound Healing and Infection Control.

Kearney, Katherine J; Ariëns, Robert A S; Macrae, Fraser L.

Semin Thromb Hemost ; 48(2): 174-187, 2022 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-34428799

5.

Thrombus Structural Composition in Cardiovascular Disease.

Alkarithi, Ghadir; Duval, Cédric; Shi, Yu; Macrae, Fraser L; Ariëns, Robert A S.

Arterioscler Thromb Vasc Biol ; 41(9): 2370-2383, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34261330

6.

GPVI (Glycoprotein VI) Interaction With Fibrinogen Is Mediated by Avidity and the Fibrinogen αC-Region.

Xu, Rui-Gang; Gauer, Julia S; Baker, Stephen R; Slater, Alexandre; Martin, Eleyna M; McPherson, Helen R; Duval, Cédric; Manfield, Iain W; Bonna, Arkadiusz M; Watson, Steve P; Ariëns, Robert A S.

Arterioscler Thromb Vasc Biol ; 41(3): 1092-1104, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33472402

7.

Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbß3 in Fibrin-Mediated Microthrombus Formation.

Perrella, Gina; Huang, Jingnan; Provenzale, Isabella; Swieringa, Frauke; Heubel-Moenen, Floor C J I; Farndale, Richard W; Roest, Mark; van der Meijden, Paola E J; Thomas, Mark; Ariëns, Robert A S; Jandrot-Perrus, Martine; Watson, Steve P; Heemskerk, Johan W M.

Arterioscler Thromb Vasc Biol ; 41(2): e97-e111, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33267658

8.

Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability: Results from a laboratory sub-study of the FEISTY trial.

Morrow, Gael B; Feller, Timea; McQuilten, Zoe; Wake, Elizabeth; Ariëns, Robert A S; Winearls, James; Mutch, Nicola J; Laffan, Mike A; Curry, Nicola.

Crit Care ; 26(1): 290, 2022 09 26.

Artigo em Inglês | MEDLINE | ID: mdl-36163263

9.

Thrombus Composition and Efficacy of Thrombolysis and Thrombectomy in Acute Ischemic Stroke.

Jolugbo, Precious; Ariëns, Robert A S.

Stroke ; 52(3): 1131-1142, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33563020

10.

Fibrinolysis in Acute and Chronic Cardiovascular Disease.

Kietsiriroje, Noppadol; Ariëns, Robert A S; Ajjan, Ramzi A.

Semin Thromb Hemost ; 47(5): 490-505, 2021 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-33878782

11.

Innate capability of clot contraction.

Ariëns, Robert A S.

Blood ; 143(6): 481-482, 2024 Feb 08.

Artigo em Inglês | MEDLINE | ID: mdl-38329778

12.

Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot, and reduce bleeding complications.

Kearney, Katherine J; Pechlivani, Nikoletta; King, Rhodri; Tiede, Christian; Phoenix, Fladia; Cheah, Ramsah; Macrae, Fraser L; Simmons, Katie J; Manfield, Iain W; Smith, Kerrie A; Spurgeon, Benjamin E J; Naseem, Khalid M; Ariens, Robert A S; McPherson, Michael J; Tomlinson, Darren C; Ajjan, Ramzi A.

Blood ; 133(11): 1233-1244, 2019 03 14.

Artigo em Inglês | MEDLINE | ID: mdl-30545831

13.

Patients with paroxysmal nocturnal hemoglobinuria demonstrate a prothrombotic clotting phenotype which is improved by complement inhibition with eculizumab.

Macrae, Fraser L; Peacock-Young, Barnaby; Bowman, Polly; Baker, Stephen R; Quested, Sam; Linton, Emma; Hillmen, Peter; Griffin, Morag; Munir, Talha; Payne, Daniel; McKinley, Claire; Clarke, Deborah; Newton, Darren J; Hill, Anita; Ariëns, Robert A S.

Am J Hematol ; 95(8): 944-952, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32311169

14.

Double diabetes: A distinct high-risk group?

Kietsiriroje, Noppadol; Pearson, Sam; Campbell, Matthew; Ariëns, Robert A S; Ajjan, Ramzi A.

Diabetes Obes Metab ; 21(12): 2609-2618, 2019 12.

Artigo em Inglês | MEDLINE | ID: mdl-31373146

15.

Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?

Slater, Alexandre; Perrella, Gina; Onselaer, Marie-Blanche; Martin, Eleyna M; Gauer, Julia S; Xu, Rui-Gang; Heemskerk, Johan Wm; Ariëns, Robert A S; Watson, Steve P.

Platelets ; 30(3): 281-289, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-30110193

16.

Ranking reactive glutamines in the fibrinogen αC region that are targeted by blood coagulant factor XIII.

Mouapi, Kelly Njine; Bell, Jacob D; Smith, Kerrie A; Ariëns, Robert A S; Philippou, Helen; Maurer, Muriel C.

Blood ; 127(18): 2241-8, 2016 05 05.

Artigo em Inglês | MEDLINE | ID: mdl-26951791

17.

Thrombin and fibrinogen Î³' impact clot structure by marked effects on intrafibrillar structure and protofibril packing.

Domingues, Marco M; Macrae, Fraser L; Duval, Cédric; McPherson, Helen R; Bridge, Katherine I; Ajjan, Ramzi A; Ridger, Victoria C; Connell, Simon D; Philippou, Helen; Ariëns, Robert A S.

Blood ; 127(4): 487-95, 2016 Jan 28.

Artigo em Inglês | MEDLINE | ID: mdl-26608329

18.

The prothrombotic state in paroxysmal nocturnal hemoglobinuria: a multifaceted source.

Peacock-Young, Barnaby; Macrae, Fraser L; Newton, Darren J; Hill, Anita; Ariëns, Robert A S.

Haematologica ; 103(1): 9-17, 2018 01.

Artigo em Inglês | MEDLINE | ID: mdl-29246924

19.

Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin α-chain crosslinking.

Byrnes, James R; Duval, Cédric; Wang, Yiming; Hansen, Caroline E; Ahn, Byungwook; Mooberry, Micah J; Clark, Martha A; Johnsen, Jill M; Lord, Susan T; Lam, Wilbur A; Meijers, Joost C M; Ni, Heyu; Ariëns, Robert A S; Wolberg, Alisa S.

Blood ; 126(16): 1940-8, 2015 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-26324704

20.

Factor XIII A-Subunit V34L Variant Affects Thrombus Cross-Linking in a Murine Model of Thrombosis.

Duval, Cédric; Ali, Majid; Chaudhry, Waleed W; Ridger, Victoria C; Ariëns, Robert A S; Philippou, Helen.

Arterioscler Thromb Vasc Biol ; 36(2): 308-16, 2016 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-26743168

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