Detalhe da pesquisa
1.
Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants.
Hum Mol Genet
; 28(20): 3339-3354, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31334547
2.
Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the αV138M variant of human pyruvate dehydrogenase.
J Biol Chem
; 293(34): 13204-13213, 2018 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29970614
3.
A multipronged approach unravels unprecedented protein-protein interactions in the human 2-oxoglutarate dehydrogenase multienzyme complex.
J Biol Chem
; 293(50): 19213-19227, 2018 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30323066
4.
Novel binding motif and new flexibility revealed by structural analyses of a pyruvate dehydrogenase-dihydrolipoyl acetyltransferase subcomplex from the Escherichia coli pyruvate dehydrogenase multienzyme complex.
J Biol Chem
; 289(43): 30161-76, 2014 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25210042
5.
Structure and function of the catalytic domain of the dihydrolipoyl acetyltransferase component in Escherichia coli pyruvate dehydrogenase complex.
J Biol Chem
; 289(22): 15215-30, 2014 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24742683
6.
Insight to the interaction of the dihydrolipoamide acetyltransferase (E2) core with the peripheral components in the Escherichia coli pyruvate dehydrogenase complex via multifaceted structural approaches.
J Biol Chem
; 288(21): 15402-17, 2013 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23580650
7.
Communication between thiamin cofactors in the Escherichia coli pyruvate dehydrogenase complex E1 component active centers: evidence for a "direct pathway" between the 4'-aminopyrimidine N1' atoms.
J Biol Chem
; 285(15): 11197-209, 2010 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-20106967
8.
Multiple roles of mobile active center loops in the E1 component of the Escherichia coli pyruvate dehydrogenase complex - Linkage of protein dynamics to catalysis.
J Mol Catal B Enzym
; 61(1-2): 14-22, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20160956
9.
Structural basis of neurosteroid anesthetic action on GABAA receptors.
Nat Commun
; 9(1): 3972, 2018 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30266951
10.
Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.
Sci Rep
; 5: 13833, 2015 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26346220
11.
A dynamic loop at the active center of the Escherichia coli pyruvate dehydrogenase complex E1 component modulates substrate utilization and chemical communication with the E2 component.
J Biol Chem
; 282(38): 28106-16, 2007 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-17635929
12.
A thiamin-bound, pre-decarboxylation reaction intermediate analogue in the pyruvate dehydrogenase E1 subunit induces large scale disorder-to-order transformations in the enzyme and reveals novel structural features in the covalently bound adduct.
J Biol Chem
; 281(22): 15296-303, 2006 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-16531404
13.
Active-site changes in the pyruvate dehydrogenase multienzyme complex E1 apoenzyme component from Escherichia coli observed at 2.32 A resolution.
Acta Crystallogr D Biol Crystallogr
; 62(Pt 11): 1382-6, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17057342
14.
Glutamate 636 of the Escherichia coli pyruvate dehydrogenase-E1 participates in active center communication and behaves as an engineered acetolactate synthase with unusual stereoselectivity.
J Biol Chem
; 280(22): 21473-82, 2005 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15802265
15.
Dual catalytic apparatus of the thiamin diphosphate coenzyme: acid-base via the 1',4'-iminopyrimidine tautomer along with its electrophilic role.
J Am Chem Soc
; 125(42): 12732-8, 2003 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-14558820
16.
Structural determinants of enzyme binding affinity: the E1 component of pyruvate dehydrogenase from Escherichia coli in complex with the inhibitor thiamin thiazolone diphosphate.
Biochemistry
; 43(9): 2405-11, 2004 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-14992577
17.
Histidine 407, a phantom residue in the E1 subunit of the Escherichia coli pyruvate dehydrogenase complex, activates reductive acetylation of lipoamide on the E2 subunit. An explanation for conservation of active sites between the E1 subunit and transketolase.
Biochemistry
; 41(52): 15459-67, 2002 Dec 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-12501174
18.
Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution.
Biochemistry
; 41(16): 5213-21, 2002 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-11955070