Detalhe da pesquisa
1.
Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms.
Nature
; 586(7831): 807-811, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32814342
2.
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.
Nature
; 575(7781): 217-223, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31666701
3.
IL-22 regulates iron availability in vivo through the induction of hepcidin.
J Immunol
; 191(4): 1845-55, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23836059
4.
Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia.
Blood
; 115(17): 3616-24, 2010 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-20053755
5.
Considerations for design, manufacture, and delivery for effective and safe T-cell engager therapies.
Curr Opin Biotechnol
; 78: 102799, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36179408
6.
Serum hepcidin but not prohepcidin may be an effective marker for anemia of inflammation (AI).
Blood Cells Mol Dis
; 45(3): 238-45, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20800515
7.
The immunomodulatory drugs lenalidomide and pomalidomide enhance the potency of AMG 701 in multiple myeloma preclinical models.
Blood Adv
; 4(17): 4195-4207, 2020 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32898244
8.
Nonclinical Safety Assessment of AMG 553, an Investigational Chimeric Antigen Receptor T-Cell Therapy for the Treatment of Acute Myeloid Leukemia.
Toxicol Sci
; 177(1): 94-107, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32589753
9.
Systematic Study of the Glutathione Reactivity of N-Phenylacrylamides: 2. Effects of Acrylamide Substitution.
J Med Chem
; 63(20): 11602-11614, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32965113
10.
AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys.
Blood Adv
; 4(17): 4180-4194, 2020 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32886754
11.
Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing.
Science
; 368(6487): 186-189, 2020 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32273468
12.
Characterization of a Novel FLT3 BiTE Molecule for the Treatment of Acute Myeloid Leukemia.
Mol Cancer Ther
; 19(9): 1875-1888, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32518207
13.
Classical and intermediate monocytes scavenge non-transferrin-bound iron and damaged erythrocytes.
JCI Insight
; 4(8)2019 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30996139
14.
Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.
ACS Med Chem Lett
; 10(9): 1302-1308, 2019 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31531201
15.
Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction.
Front Pharmacol
; 8: 838, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29209212
16.
Bispecific T cell engager (BiTE®) antibody constructs can mediate bystander tumor cell killing.
PLoS One
; 12(8): e0183390, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28837681
17.
High-Throughput Mass Spectrometric Analysis of Covalent Protein-Inhibitor Adducts for the Discovery of Irreversible Inhibitors: A Complete Workflow.
J Biomol Screen
; 21(2): 136-44, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26676098
18.
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.
Nat Med
; 22(8): 945-51, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27428900
19.
Design Rationale and Development Approach for Pegfilgrastim as a Long-Acting Granulocyte Colony-Stimulating Factor.
BioDrugs
; 29(3): 185-98, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25998211
20.
Systematic Study of the Glutathione (GSH) Reactivity of N-Arylacrylamides: 1. Effects of Aryl Substitution.
J Med Chem
; 58(23): 9171-8, 2015 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26580091