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BACKGROUND AND PURPOSE: Dizziness may persist even after the causative vestibular imbalance subsides. Although the precise mechanism of chronic dizziness is unknown, various cerebral activity changes associated with it have been reported. To understand its mechanism in the absence of the causative vestibular imbalance, we compared cerebral changes in chronic dizziness with and without persistent vestibular imbalance. METHODS: Between September 2014 and March 2020, we examined regional cerebral blood flow (rCBF) in 12 patients having chronic post-lateral medullary infarction dizziness with persistent brainstem vestibular imbalance and 23 patients having chronic dizziness without currently active vestibular imbalance using single-photon emission computed tomography (SPECT) with 99m Technetium-ethyl cysteinate dimer. Further, we analyzed the SPECT images using a voxel-based group comparison. RESULTS: We observed a decreased rCBF in the occipital lobe and increased rCBF in the medial and inferior parts of the temporal lobe in patients having chronic dizziness with and without active vestibular imbalance compared to healthy controls. However, only patients having chronic dizziness without active vestibular imbalance exhibited increased rCBF in the frontal lobe, including the orbitofrontal cortex. CONCLUSION: This is the first study to highlight the difference in rCBF changes between patients having chronic dizziness with and without active vestibular imbalance. Decreased occipital lobe activity and increased medial and inferior temporal lobe activity may be related to keeping dizziness perception triggered regardless of the presence or absence of active vestibular imbalance, whereas increased frontal lobe activity may explain the dizziness background to persist after the disappearance of vestibular imbalance.
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OBJECTIVE: Many studies have documented the clinical usefulness of standardized uptake values (SUV) for diagnosis. However, in the event of injection error, accurate measurements cannot be obtained if the radioactivity of fluorodeoxyglucose (FDG) leakage is not subtracted from the administered dosage. Here, a correction formula for radioactivity estimation that takes into account the radioactivity of FDG leakage was derived on the basis of a phantom experiment. Furthermore, to determine whether SUV could be accurately calculated by the correction formula, we performed a volunteer study. METHODS: Images were displayed by altering the conversion constant from 1.0, 0.1 to 0.01, and the range of correctable counts was verified on the basis of image inversion. To estimate the radioactivity of FDG leakage by imaging, the count of the leakage was measured, converted into a radioactivity concentration using a cross-calibration factor (CCF), and multiplied by volume, as measured by imaging. Three factors that markedly affect count, i.e., count rate performance, partial volume effect and crosstalk, were assessed in phantom studies in order to derive a correction formula. In addition, to clarify the accuracy of the correction formula, we attached to the right elbow. RESULTS: With a conversion constant of 0.1, there was no image inversion at