Detalhe da pesquisa
1.
Characterization of Hepatic UDP-Glucuronosyltransferase Enzyme Abundance-Activity Correlations and Population Variability Using a Proteomics Approach and Comparison with Cytochrome P450 Enzymes.
Drug Metab Dispos
; 49(9): 760-769, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34187837
2.
Use of Phenotypically Poor Metabolizer Individual Donor Human Liver Microsomes To Identify Selective Substrates of UGT2B10.
Drug Metab Dispos
; 48(3): 176-186, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31839590
3.
Optimization of Experimental Conditions of Automated Glucuronidation Assays in Human Liver Microsomes Using a Cocktail Approach and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry.
Drug Metab Dispos
; 47(2): 124-134, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30478159
4.
Meta-analysis of expression of hepatic organic anion-transporting polypeptide (OATP) transporters in cellular systems relative to human liver tissue.
Drug Metab Dispos
; 43(4): 424-32, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25564656
5.
Generic Workflow to Predict Medicine Concentrations in Human Milk Using Physiologically-Based Pharmacokinetic (PBPK) Modelling-A Contribution from the ConcePTION Project.
Pharmaceutics
; 15(5)2023 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37242712
6.
Current Practices, Gap Analysis, and Proposed Workflows for PBPK Modeling of Cytochrome P450 Induction: An Industry Perspective.
Clin Pharmacol Ther
; 112(4): 770-781, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34862964
7.
Pediatric Pharmacokinetics and Dose Predictions: A Report of a Satellite Meeting to the 10th Juvenile Toxicity Symposium.
Clin Transl Sci
; 14(1): 29-35, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32702198
8.
Coexpression of Human Hepatic Uridine Diphosphate Glucuronosyltransferase Proteins: Implications for Ontogenetic Mechanisms and Isoform Coregulation.
J Clin Pharmacol
; 60(6): 722-733, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31879975
9.
The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling.
Clin Pharmacokinet
; 58(2): 189-211, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29862468
10.
Characterization of the Ontogeny of Hepatic UDP-Glucuronosyltransferase Enzymes Based on Glucuronidation Activity Measured in Human Liver Microsomes.
J Clin Pharmacol
; 59 Suppl 1: S42-S55, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31502688