1.
Antimicrob Agents Chemother
; 46(6): 2041-5, 2002 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12019137
RESUMO
Bis-lentivirus lytic protein 1 (Bis-LLP1) and polymyxin B exhibited similar killing activities against Serratia marcescens. By electron microscopy, bis-LLP1 interacted with the outer and cytoplasmic bacterial membranes, while polymyxin B affected only the outer membrane. The results of standard biochemical probes supported the findings of the electron microscopy studies, suggesting that these antimicrobial peptides have different mechanisms of action.