Detalhe da pesquisa
1.
Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia.
Acta Neuropathol
; 137(1): 71-88, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30382371
2.
Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.
J Biol Chem
; 287(8): 5253-66, 2012 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-22158868
3.
Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.
J Biol Chem
; 286(19): 17217-26, 2011 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21454574
4.
Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.
Proc Natl Acad Sci U S A
; 105(4): 1343-6, 2008 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-18212130
5.
Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease.
Nat Aging
; 1(10): 932-947, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36172600
6.
Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS.
J Neurosci
; 28(6): 1452-9, 2008 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-18256266
7.
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
Nat Med
; 24(5): 647-657, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29632371
8.
Author Correction: Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease.
Nat Aging
; 1(12): 1202, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37117528
9.
Genetic correction of tauopathy phenotypes in neurons derived from human induced pluripotent stem cells.
Stem Cell Reports
; 1(3): 226-34, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24319659
10.
Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.
Cell Stem Cell
; 11(1): 100-9, 2012 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22683203
11.
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.
Proc Natl Acad Sci U S A
; 102(51): 18694-9, 2005 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16344479
12.
Regulatable liver expression of the rabbit apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1 (APOBEC-1) in mice lacking endogenous APOBEC-1 leads to aberrant hyperediting.
Biochem J
; 369(Pt 2): 255-62, 2003 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12374571