1.
Bioorg Chem
; 39(2): 67-72, 2011 Apr.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21419469
RESUMO
Conformationally constrained analogues of the hormone melatonin with a side chain incorporated into the bicyclic bridgehead core were synthesized based on the homology modeling and molecular docking studies performed for the MT(2) melatonin receptor. The methoxy-indole derivative fused with exo-N-acetamino-substituted bicyclo[2.2.2]octane was found to possess nanomolar MT(2) receptor affinity.