Detalhe da pesquisa
1.
High Accuracy Prediction of PROTAC Complex Structures.
J Am Chem Soc
; 145(13): 7123-7135, 2023 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36961978
2.
Functional characterization of a PROTAC directed against BRAF mutant V600E.
Nat Chem Biol
; 16(11): 1170-1178, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32778845
3.
N-Alkyl Carbamoylimidazoles as Isocyanate Equivalents: Exploration of the Reaction Scope for the Synthesis of Ureas, Hydantoins, Carbamates, Thiocarbamates, and Oxazolidinones.
J Org Chem
; 87(17): 11329-11349, 2022 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35968929
4.
Di-tert-butyl Ethynylimidodicarbonate as a General Synthon for the ß-Aminoethylation of Organic Electrophiles: Application to the Formal Synthesis of Pyrrolidinoindoline Alkaloids (±)-CPC-1 and (±)-Alline.
J Org Chem
; 85(13): 8447-8461, 2020 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32495626
5.
An Alumino-Mannich Reaction of Organoaluminum Reagents, Silylated Amines, and Aldehydes.
Chemistry
; 24(23): 6071-6074, 2018 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29518283
6.
An Approach to the 9-Oxo-10-oxabicyclo[5.3.0]dec-2-ene Core of the Guaianolide and Pseudoguaianolide Sesquiterpenes via a Domino Electrocyclic Ring-Opening/Carboxylic Acid Trapping of a gem-Dibromocyclopropane.
J Org Chem
; 83(22): 13799-13810, 2018 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30303376
7.
DABO Boronate Promoted Conjugate Allylation of α,ß-Unsaturated Aldehydes Using Copper(II) Catalysis.
J Org Chem
; 81(15): 6774-8, 2016 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27362535
8.
Organoboron-based allylation approach to the total synthesis of the medium-ring dilactone (+)-antimycin A(1b).
J Org Chem
; 79(16): 7415-24, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25019929
9.
Amidation reactions from the direct coupling of metal carboxylate salts with amines.
J Org Chem
; 79(3): 943-54, 2014 Feb 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24354665
10.
Total synthesis and antibacterial testing of the A54556 cyclic acyldepsipeptides isolated from Streptomyces hawaiiensis.
J Nat Prod
; 77(10): 2170-81, 2014 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25255326
11.
A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.
Blood
; 117(6): 1986-97, 2011 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21135258
12.
A hetero Diels-Alder approach to the synthesis of chromans (3,4-dihydrobenzopyrans) using oxonium ion chemistry: the oxa-Povarov reaction.
J Org Chem
; 78(4): 1404-20, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23231321
13.
Mild double allylboration reactions of nitriles and acid anhydrides using potassium allyltrifluoroborate.
J Org Chem
; 78(3): 1216-21, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23214971
14.
Total Synthesis of the 2,5-Disubstituted γ-Pyrone E1 UAE Inhibitor Himeic Acid A.
Org Lett
; 25(41): 7502-7506, 2023 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37801638
15.
The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells.
Blood
; 116(18): 3593-603, 2010 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20644115
16.
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
Blood
; 115(11): 2251-9, 2010 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20075161
17.
Synthesis and reactivity of N-alkyl carbamoylimidazoles: development of N-methyl carbamoylimidazole as a methyl isocyanate equivalent.
J Org Chem
; 77(22): 10362-8, 2012 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23083426
18.
Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.
J Med Chem
; 65(19): 12725-12746, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36117290
19.
CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding.
Nat Rev Chem
; 6(4): 287-295, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35783295
20.
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.
Blood
; 114(14): 3064-73, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19589922