[Existing report of the health care of detainees and of the organization of the drug circuit in prisons in France]. / État des lieux de la prise en charge sanitaire des détenus et de l'organisation du circuit médicamenteux en milieu carcéral en France.

Since the healthcare system reform in prisons by the law of 18 January 1994, health care for prisoners has depended on the public hospital service. Since the application of this law, hospital pharmacists have been responsible for the health product circuit in the prison. In order to reassess the overall health care of detainees in prison in 2022, a study is being carried out. This study also aims to carry out an inventory of the organization of the drug circuit in prisons in France. In June 2022, a questionnaire was sent by email to pharmacists in charge of supplying health products to one or more prison health units in France. The response rate to the questionnaire is 34 %. The average number of full-time equivalent (FTE) somatic doctors is 1.25. The average FTE pharmacist and pharmacy technician are respectively 0.4 and 0.96. Prescriptions are computerized in 84 % of cases. Therapeutic education and pharmaceutical interviews are carried out in 24 % and 20 % respectively. This study showed an overall improvement in the care of prisoners and the organization of the medication circuit in France compared to the last study. Pharmacists are more present in prisons. However, clinical pharmacy and health promotion actions are insufficiently deployed.

Silica-clay nanocomposites for the removal of antibiotics in the water usage cycle.

The increasingly frequent detection of resistant organic micropollutants in waters calls for better treatment of these molecules that are recognized to be dangerous for human health and the environment. As an alternative to conventional adsorbent material such as activated carbon, silica-clay nanocomposites were synthesized for the removal of pharmaceuticals in contaminated water. Their efficiency with respect to carbamazepine, ciprofloxacin, danofloxacin, doxycycline, and sulfamethoxazole was assessed in model water and real groundwater spiked with the five contaminants. Results showed that the efficacy of contaminant removal depends on the chemical properties of the micropollutants. Among the adsorbents tested, the nanocomposite made of 95% clay and 5% SiO2 NPs was the most efficient and was easily recovered from solution after treatment compared with pure clay, for example. The composite is thus a good candidate in terms of operating costs and environmental sustainability for the removal of organic contaminants.

Cost-performance indicator for comparative environmental assessment of water treatment plants.

To compare potable water production plants on the basis of the environmental impacts generated by the treatment, including water resource depletion, Life Cycle Assessment (LCA) methodology is often used as referential. A comparison based only on the environmental impacts can however be misleading. Criteria for drinkability are usually defined as thresholds and the actual water quality gain achieved by different treatment chains shall be considered in the assessment for a fair comparison. Otherwise, chains treating low quality water resources could be disadvantaged as compared to alternatives using higher quality water resource, also when the depletion of the raw resource is included in the impact assessment. In this study, a novel Cost-Performance (CP) indicator has been developed and tested for the case of two existing water treatment plants located in the Paris Region. CP is the ratio between the total environmental impact generated by the treatment (i.e. the LCA score, eventually monetarised) and the total quality gain from raw to treated water. For the test case, three life cycle impact assessment methods, ReCiPe, Stepwise and Eco-costs (the latter two including monetarisation) have been considered. The water quality gain is based on 8 relevant parameters measured before and after treatment. The parameters are further aggregated using the French water quality valuation system SEQ-Eau. Paired t-test is then used to calculate the confidence interval for the average quality gain which then determines the confidence interval of the CP. Independent t-test on the CPs of the two alternative plants allows checking if their performances can be distinguished. Although in the specific test case the comparison is not conclusive, due to the similarity between the water quality gains, realistic breakthrough values have been obtained, especially using ReCiPe. The meaningfulness of the monetarisation of the LCA results has been highlighted as well.

Membrane characterization by microscopic and scattering methods: multiscale structure.

Several microscopic and scattering techniques at different observation scales (from atomic to macroscopic) were used to characterize both surface and bulk properties of four new flat-sheet polyethersulfone (PES) membranes (10, 30, 100 and 300 kDa) and new 100 kDa hollow fibers (PVDF). Scanning Electron Microscopy (SEM) with "in lens" detection was used to obtain information on the pore sizes of the skin layers at the atomic scale. White Light Interferometry (WLI) and Atomic Force Microscopy (AFM) using different scales (for WLI: windows: 900 × 900 µm2 and 360 × 360 µm2; number of points: 1024; for AFM: windows: 50 × 50 µm2 and 5 × 5 µm2; number of points: 512) showed that the membrane roughness increases markedly with the observation scale and that there is a continuity between the different scan sizes for the determination of the RMS roughness. High angular resolution ellipsometric measurements were used to obtain the signature of each cut-off and the origin of the scattering was identified as coming from the membrane bulk.

A phycocyanin probe as a tool for monitoring cyanobacteria in freshwater bodies.

In many countries, the presence of cyanobacteria in freshwater bodies used for both drinking water and recreational purposes is under increasing public health attention. Water managers are considering how to implement monitoring that leads to a minimization of the risks incurred by the users of potentially contaminated sites. To address this question, this study involved assessing the performance of a submersible probe for measuring phycocyanin-specific fluorescence as a function of cyanobacterial biomass, with the aim of applying it as a tool for surveillance management. Its advantages and limits compared to more traditional analyses are discussed. The monitoring of cyanobacteria in the water bodies of western France was carried out using a minifluorimeter specific to the fluorescence of phycocyanin, a pigment specific to cyanobacteria. The results are compared with the analyses recommended by the World Health Organisation (chlorophyll a and cell counting). This study based on nearly 800 samples shows a significant correlation between the phycocyanin content and the cyanobacterial biomass, expressed as the number of cells per mL (R2 = 0.73). This submersible probe is simple and rapid to use, making it possible to take into account horizontal and vertical heterogeneities in the proliferation growth. In this way, we are able to detect at an early stage the conditions that could potentially lead to a risk, in order to start sampling. Due to its sensitivity, this tool proves suitable for monitoring aimed at reducing the risks incurred by the users of contaminated sites and launching preventative actions. The use of the phycocyanin probe provides an effective tool to complement traditional analyses of cyanobacterial presence. It is suggested that a surveillance protocol based on phycocyanin concentration can significantly improved the accuracy of the extent of cyanobacterial bloom development in the light of spatial and temporal variabilities associated with these occurrences.

Effect of oxygen in a thin-film rotating disk photocatalytic reactor.

A novel experimental procedure was developed to measure oxygen mass transfer during the oxygenation of water in a thin film of a rotating disk photocatalytic reactor (RDPR). The increase in dissolved oxygen (DO) of initially deaerated water was monitored with time in the reactor vessel at different disk angular velocities after exposure of the reactor to the atmosphere. Oxygenation was predominantly achieved by oxygen mass transport through the thin liquid film carried by the disk and to a much lesser extent by direct oxygenation of the water in the reactor vessel via a surface renewal mechanism. A mathematical model was developed to simulate the phenomenon considering both cases of presence and absence of oxygen mass transport limitations. In the latter case, the model considered that the amount of liquid carried by the disk was saturated with oxygen when returning to the reactor vessel. On the basis of the model and the experimental data, it was proven that mass-transfer limitations existed until the water in the reactor vessel became saturated with oxygen. Results obtained from the model were validated by an alternative analysis using dimensionless groups characteristic to the system. The study revealed that the mass-transfer coefficient increased linearly with disk angular velocity and thus disk Reynolds number. The results showed that oxygen mass-transfer limitations decreased with increasing disk angular velocity, mainly due to an increase in the overall mass-transfer coefficient. In the presence of UV radiation, the influence of oxygen on the photocatalytic oxidation of 4-chlorobenzoic acid was investigated in the RDPR operated in batch and continuous mode. The photocatalytic reactions occurred in a thin film of liquid carried by the disk in the presence of UV radiation and ST-B01 composite spherical ceramic (SiO2/Al2O3) balls coated with anatase TiO2 catalyst. It was found that the initial degradation rate followed Langmuir kinetics with respect to oxygen concentration in the gas phase. When the oxygen concentration in the gas phase surpassed that in air, the degradation rates did not improve significantly, suggesting that operation with air instead of oxygen is most probably a more realistic practical choice. Measurements of DO during the presence and absence of UV radiation suggested that the photocatalytic reactions were mainly oxygen concentration-limited rather than oxygen mass-transfer-limited.