RESUMO
Golimumab is a human IgG monoclonal antibody specific for human tumor necrosis factor alpha. Golimumab has been approved for use in rheumatological conditions; however, its use in inflammatory bowel disease is still being evaluated in clinical trials. We report a case of an exacerbation of ulcerative proctitis after starting on golimumab for ankylosing spondylitis.
Assuntos
Anticorpos Monoclonais/efeitos adversos , Anticorpos Monoclonais/uso terapêutico , Doenças Inflamatórias Intestinais/induzido quimicamente , Espondilite Anquilosante/tratamento farmacológico , Adalimumab , Adulto , Anticorpos Monoclonais Humanizados/uso terapêutico , Diarreia/induzido quimicamente , Humanos , Doenças Inflamatórias Intestinais/patologia , Masculino , Proctite/induzido quimicamente , Proctite/patologia , Espondilite Anquilosante/complicações , Fator de Necrose Tumoral alfa/antagonistas & inibidoresRESUMO
The incidence of drug-related acute liver failure is approximately 14 per 100,000 populations. Drug-induced liver injury may take place through a variety of mechanism. Withdrawal of the offending agent may result in complete recovery. Clindamycin is known to cause mild derangement of liver function; however, acute liver injury causing severe derangement of liver function associated with encephalopathy is uncommon.
Assuntos
Antibacterianos/efeitos adversos , Doença Hepática Induzida por Substâncias e Drogas/epidemiologia , Clindamicina/efeitos adversos , Disfunção Cognitiva/epidemiologia , Falência Hepática Aguda/induzido quimicamente , Idoso , Humanos , MasculinoRESUMO
Multidrug resistant pneumonia is an entity, which is difficult to treat, and in a patient with acute renal insufficiency, it leaves a physician with a handful of antibiotics to be considered. Aerosolized administration of antibiotics is one option that can be contemplated for a patient with acute renal insufficiency to avoid the nephrotoxic effect of the antibiotics.
Assuntos
Injúria Renal Aguda/fisiopatologia , Amicacina/uso terapêutico , Antibacterianos/uso terapêutico , Pneumonia Bacteriana/tratamento farmacológico , Administração por Inalação , Aerossóis , Amicacina/administração & dosagem , Amicacina/efeitos adversos , Antibacterianos/administração & dosagem , Antibacterianos/efeitos adversos , Farmacorresistência Bacteriana Múltipla , Feminino , Humanos , Pessoa de Meia-Idade , Pneumonia Bacteriana/microbiologiaRESUMO
Management of soft tissue sarcomas can be very challenging because they have a high rate of metastasis, especially to the lungs, and respond very poorly to the currently available chemotherapeutic drugs. We present a case of epithelioid sarcoma in which complete remission of pulmonary metastases was observed after treatment with a single agent, navelbine, a vinca alkaloid, and a potential therapeutic agent. The patient has been persistently free of metastases for 4 years since treatment with navelbine. Further studies are warranted to establish the role of navelbine for the treatment of soft tissue sarcoma and their metastases.
Assuntos
Antineoplásicos Fitogênicos/uso terapêutico , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/secundário , Sarcoma/tratamento farmacológico , Sarcoma/secundário , Vimblastina/análogos & derivados , Idoso , Antebraço , Humanos , Neoplasias Pulmonares/diagnóstico por imagem , Masculino , Imagem Multimodal , Tomografia por Emissão de Pósitrons , Indução de Remissão/métodos , Sarcoma/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Vimblastina/uso terapêutico , VinorelbinaAssuntos
Apendicectomia , Apendicite , Doença Aguda , Antibacterianos , Humanos , Estudos Retrospectivos , Resultado do TratamentoRESUMO
Caroli's syndrome is characterized by bile duct ectasia in association with hepatic fibrosis. It is usually transmitted in an autosomal recessive fashion and has been well documented to be associated with autosomal recessive polycystic kidney disease and occasionally with autosomal dominant polycystic kidney disease. However, there has been only few case reports published with Caroli's syndrome diagnosed postrenal transplantation.
Assuntos
Doença de Caroli/diagnóstico , Transplante de Rim , Doença de Caroli/terapia , Diagnóstico por Imagem , Humanos , Testes de Função Hepática , Masculino , Pessoa de Meia-IdadeRESUMO
Large perigastric or periduodenal pseudocysts are a potential cause of gastric outlet obstruction, usually requiring interventional drainage of the pseudocysts. In contrary most of the small pseudocysts are asymptomatic and require no therapy. However, certain small pseudocysts can produce clinically significant problem depending on their location. Here we report a case of small pseudocyst (12.0 mm in width) with a unique shape and location causing significant Gastric outlet obstruction treated successfully with endoscopy.
RESUMO
Acute mesenteric ischemia has a variety of etiologies. Non-occulusive mesenteric ischemia accounts for 20-30% of patients with acute mesenteric ischemia. We describe a case of non-occulusive jejunal ischemia leading to infarction that occurred in a patient with cirrhosis and no previous history of cardiovascular disease.