Detalhe da pesquisa
1.
A mechanistic systems pharmacology modeling platform to investigate the effect of PD-L1 expression heterogeneity and dynamics on the efficacy of PD-1 and PD-L1 blocking antibodies in cancer.
J Theor Biol
; 522: 110697, 2021 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33794288
2.
Computational modeling of synergistic interaction between αVß3 integrin and VEGFR2 in endothelial cells: Implications for the mechanism of action of angiogenesis-modulating integrin-binding peptides.
J Theor Biol
; 455: 212-221, 2018 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30036530
3.
Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells.
PLoS Comput Biol
; 13(2): e1005332, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28178265
4.
Novel fluorescence resonance energy transfer-based reporter reveals differential calcineurin activation in neonatal and adult cardiomyocytes.
J Physiol
; 593(17): 3865-84, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26096996
5.
Eliciting the antitumor immune response with a conditionally activated PD-L1 targeting antibody analyzed with a quantitative systems pharmacology model.
CPT Pharmacometrics Syst Pharmacol
; 13(1): 93-105, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38058278
6.
Combining Multikinase Tyrosine Kinase Inhibitors Targeting the Vascular Endothelial Growth Factor and Cluster of Differentiation 47 Signaling Pathways Is Predicted to Increase the Efficacy of Antiangiogenic Combination Therapies.
ACS Pharmacol Transl Sci
; 6(5): 710-726, 2023 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37200806
7.
TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies.
Cancer Res Commun
; 2(6): 489-502, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36923556
8.
Computer Simulation of TSP1 Inhibition of VEGF-Akt-eNOS: An Angiogenesis Triple Threat.
Front Physiol
; 9: 644, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29899706
9.
Three-Dimensional Transport Model for Intravitreal and Suprachoroidal Drug Injection.
Invest Ophthalmol Vis Sci
; 59(12): 5266-5276, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30383198
10.
Biomimetic peptide display from a polymeric nanoparticle surface for targeting and antitumor activity to human triple-negative breast cancer cells.
J Biomed Mater Res A
; 106(6): 1753-1764, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29424479
11.
Corrigendum: Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation.
Front Physiol
; 8: 147, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28275355
12.
Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation.
Front Physiol
; 8: 48, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28220078
13.
Quantitative Translation in Immuno-Oncology Research and Development.
Clin Pharmacol Ther
; 108(3): 430-433, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32645203
14.
Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels.
Curr Mol Pharmacol
; 8(2): 188-205, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25966688
15.
Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels.
Nat Commun
; 4: 1717, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23591884
16.
Continuously tunable Ca(2+) regulation of RNA-edited CaV1.3 channels.
Cell Rep
; 5(2): 367-77, 2013 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-24120865
17.
A mathematical model of electrotonic interactions between ventricular myocytes and fibroblasts.
Biophys J
; 92(11): 4121-32, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17307821
18.
Inhibition of cAMP-dependent protein kinase under conditions occurring in the cardiac dyad during a Ca2+ transient.
Biophys J
; 91(2): 433-43, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16632511
19.
Ca2+ regulation in the near-membrane microenvironment in smooth muscle cells.
Biophys J
; 85(3): 1754-65, 2003 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-12944290