Detalhe da pesquisa
1.
Enhanced striatopallidal gamma-aminobutyric acid (GABA)A receptor transmission in mouse models of huntington's disease.
Mov Disord
; 34(5): 684-696, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30726572
2.
Age- and sex-related changes in cortical and striatal nitric oxide synthase in the Q175 mouse model of Huntington's disease.
Nitric Oxide
; 83: 40-50, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30528913
3.
Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor.
Bioorg Med Chem Lett
; 29(1): 83-88, 2019 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30463802
4.
HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
PLoS Biol
; 11(11): e1001717, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24302884
5.
Cholinergic deficits selectively boost cortical intratelencephalic control of striatum in male Huntington's disease model mice.
Nat Commun
; 14(1): 1398, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36914640
6.
Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology.
J Med Chem
; 65(18): 12445-12459, 2022 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36098485
7.
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease.
J Med Chem
; 65(14): 9819-9845, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35816678
8.
HDinHD: A Rich Data Portal for Huntington's Disease Research.
J Huntingtons Dis
; 10(3): 405-412, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34397420
9.
Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease.
ACS Med Chem Lett
; 12(3): 380-388, 2021 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33738065
10.
Phosphodiesterase 9A Inhibition Facilitates Corticostriatal Transmission in Wild-Type and Transgenic Rats That Model Huntington's Disease.
Front Neurosci
; 14: 466, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32581668
11.
In vitro phosphodiesterase 10A (PDE10A) binding in whole hemisphere human brain using the PET radioligand [18F]MNI-659.
Brain Res
; 1711: 140-145, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30664847
12.
Real-time measurement of exocytosis and endocytosis using interference of light.
Neuron
; 40(6): 1075-86, 2003 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-14687543
13.
Temporal synaptic tagging by I(h) activation and actin: involvement in long-term facilitation and cAMP-induced synaptic enhancement.
Neuron
; 33(4): 601-13, 2002 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-11856533
14.
Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications.
Neuropsychopharmacology
; 33(3): 685-700, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17487225
15.
Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.
Trends Neurosci
; 40(7): 422-437, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28578789
16.
The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease.
Exp Neurol
; 282: 99-118, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27163548
17.
Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington's Disease Models.
Neuron
; 92(6): 1220-1237, 2016 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27916455
18.
Efficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis).
PLoS One
; 9(7): e102449, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25050979
19.
The PDE1/5 Inhibitor SCH-51866 Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease.
PLoS Curr
; 62014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24558637
20.
HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo.
PLoS One
; 8(11): e80849, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24278330