Detalhe da pesquisa
1.
Enhancing Hit Discovery in Virtual Screening through Absolute Protein-Ligand Binding Free-Energy Calculations.
J Chem Inf Model
; 63(10): 3171-3185, 2023 05 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37167486
2.
Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors.
Trends Biochem Sci
; 43(7): 533-546, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29735399
3.
Beta-arrestins operate an on/off control switch for focal adhesion kinase activity.
Cell Mol Life Sci
; 77(24): 5259-5279, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-32040695
4.
Receptor sequestration in response to ß-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.
Proc Natl Acad Sci U S A
; 112(37): E5160-8, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26324936
5.
Quantifying biased signaling in GPCRs using BRET-based biosensors.
Methods
; 92: 5-10, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25890247
6.
Mapping the putative G protein-coupled receptor (GPCR) docking site on GPCR kinase 2: insights from intact cell phosphorylation and recruitment assays.
J Biol Chem
; 289(36): 25262-75, 2014 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25049229
7.
Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors.
ACS Bio Med Chem Au
; 3(6): 507-515, 2023 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38144256
8.
Induced-Fit Docking Enables Accurate Free Energy Perturbation Calculations in Homology Models.
J Chem Theory Comput
; 18(9): 5710-5724, 2022 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35972903
9.
Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.
Nat Commun
; 12(1): 4688, 2021 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34344896
10.
Identification of Allosteric Inhibitors against Active Caspase-6.
Sci Rep
; 9(1): 5504, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30940883
11.
Induced fit in liver X receptor beta: a molecular dynamics-based investigation.
Proteins
; 72(3): 873-82, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18275080
12.
A new inhibitor of the ß-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling.
Nat Commun
; 8: 15054, 2017 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416805
13.
Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay.
Sci Rep
; 5: 37581, 2016 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27874094
14.
Differential ß-arrestin-dependent conformational signaling and cellular responses revealed by angiotensin analogs.
Sci Signal
; 5(221): ra33, 2012 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22534132
15.
SHEF: a vHTS geometrical filter using coefficients of spherical harmonic molecular surfaces.
J Mol Model
; 14(5): 393-401, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18330602
16.
Multiple-step virtual screening using VSM-G: overview and validation of fast geometrical matching enrichment.
J Mol Model
; 14(2): 135-48, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18172702
17.
A fast surface-matching procedure for protein-ligand docking.
J Mol Model
; 12(6): 965-72, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16673083