Detalhe da pesquisa
1.
Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity.
Nature
; 570(7761): E53, 2019 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-31142845
2.
Design of amidobenzimidazole STING receptor agonists with systemic activity.
Nature
; 564(7736): 439-443, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30405246
3.
Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ.
Bioorg Med Chem Lett
; 30(7): 126955, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32035698
4.
Benzothiazole-based compounds as potent endothelial lipase inhibitors.
Bioorg Med Chem Lett
; 29(20): 126673, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31519373
5.
Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase.
Bioorg Med Chem Lett
; 29(15): 1918-1921, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31176700
6.
Corrigendum to "Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase" [Bioorg. Med. Chem. Lett. 29 (2019) 1918-1921].
Bioorg Med Chem Lett
; 29(17): 2525, 2019 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31353296
7.
Estimation of the extent of in vivo formation of a mutagenic aromatic amine from a potent thyromimetic compound: correlation of in vitro and in vivo findings.
Chem Res Toxicol
; 24(6): 905-12, 2011 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21574629
8.
Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies.
Bioorg Med Chem Lett
; 21(22): 6856-60, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21962575
9.
Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo.
J Med Chem
; 63(4): 1660-1670, 2020 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31990537
10.
Design, synthesis, and anti-inflammatory properties of orally active 4-(phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha mitogen-activated protein kinase inhibitors.
J Med Chem
; 51(1): 4-16, 2008 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18072718
11.
Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase.
ACS Med Chem Lett
; 9(12): 1263-1268, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613337
12.
2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatinib, BMS-354825) as a potent pan-Src kinase inhibitor.
J Med Chem
; 49(23): 6819-32, 2006 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-17154512
13.
Discovery of Highly Potent Liver X Receptor ß Agonists.
ACS Med Chem Lett
; 7(12): 1207-1212, 2016 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27994765
14.
Beneficial and Adverse Effects of an LXR Agonist on Human Lipid and Lipoprotein Metabolism and Circulating Neutrophils.
Cell Metab
; 24(2): 223-33, 2016 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27508871
15.
Imidazoquinoxaline Src-family kinase p56Lck inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo- [1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity.
J Med Chem
; 47(18): 4517-29, 2004 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-15317463
16.
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.
J Med Chem
; 47(27): 6658-61, 2004 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15615512
17.
Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties.
J Med Chem
; 56(23): 9586-600, 2013 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24182233
18.
Discovery of pyrazine carboxamide CB1 antagonists: the introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series.
Bioorg Med Chem Lett
; 17(14): 3978-82, 2007 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17513109
19.
Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors.
Bioorg Med Chem Lett
; 14(24): 6061-6, 2004 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15546730