Detalhe da pesquisa
1.
Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer.
J Med Chem
; 63(2): 512-528, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31721572
2.
Effects of depletion of neutrophils or macrophages on the inflammatory response induced by metalloelastase (MMP-12) in mice airways.
Eur J Pharmacol
; 579(1-3): 374-81, 2008 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18001704
3.
The selective intravenous inhibitor of the MET tyrosine kinase SAR125844 inhibits tumor growth in MET-amplified cancer.
Mol Cancer Ther
; 14(2): 384-94, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25504634
4.
Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors.
J Med Chem
; 58(1): 376-400, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25402320
5.
Discovery and optimization of pyrimidone indoline amide PI3Kß inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers.
J Med Chem
; 57(3): 903-20, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24387221
6.
Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kß inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers.
J Med Chem
; 55(10): 4788-805, 2012 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22524426