Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Structural and Functional Analysis of a ß₂-Adrenergic Receptor Complex with GRK5.

Komolov, Konstantin E; Du, Yang; Duc, Nguyen Minh; Betz, Robin M; Rodrigues, João P G L M; Leib, Ryan D; Patra, Dhabaleswar; Skiniotis, Georgios; Adams, Christopher M; Dror, Ron O; Chung, Ka Young; Kobilka, Brian K; Benovic, Jeffrey L.

Cell ; 169(3): 407-421.e16, 2017 04 20.

Artigo em Inglês | MEDLINE | ID: mdl-28431242

2.

Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.

Komolov, Konstantin E; Sulon, Sarah M; Bhardwaj, Anshul; van Keulen, Siri C; Duc, Nguyen Minh; Laurinavichyute, Daniela K; Lou, Hua Jane; Turk, Benjamin E; Chung, Ka Young; Dror, Ron O; Benovic, Jeffrey L.

Mol Cell ; 81(2): 323-339.e11, 2021 01 21.

Artigo em Inglês | MEDLINE | ID: mdl-33321095

3.

G-protein-coupled receptors signal victory.

Benovic, Jeffrey L.

Cell ; 151(6): 1148-50, 2012 Dec 07.

Artigo em Inglês | MEDLINE | ID: mdl-23201142

4.

The Role of G Protein-Coupled Receptors and Receptor Kinases in Pancreatic ß-Cell Function and Diabetes.

Varney, Matthew J; Benovic, Jeffrey L.

Pharmacol Rev ; 76(2): 267-299, 2024 Feb 13.

Artigo em Inglês | MEDLINE | ID: mdl-38351071

5.

Identification of a ß-arrestin-biased negative allosteric modulator for the ß₂-adrenergic receptor.

Ippolito, Michael; De Pascali, Francesco; Hopfinger, Nathan; Komolov, Konstantin E; Laurinavichyute, Daniela; Reddy, Poli Adi Narayana; Sakkal, Leon A; Rajkowski, Kyle Z; Nayak, Ajay P; Lee, Justin; Lee, Jordan; Cao, Gaoyuan; Donover, Preston S; Reichman, Melvin; An, Steven S; Salvino, Joseph M; Penn, Raymond B; Armen, Roger S; Scott, Charles P; Benovic, Jeffrey L.

Proc Natl Acad Sci U S A ; 120(31): e2302668120, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37490535

6.

Kinome profiling identifies MARK3 and STK10 as potential therapeutic targets in uveal melanoma.

Baqai, Usman; Kurimchak, Alison M; Trachtenberg, Isabella V; Purwin, Timothy J; Haj, Jelan I; Han, Anna; Luo, Kristine; Pachon, Nikole Fandino; Jeon, Angela; Chua, Vivian; Davies, Michael A; Gutkind, J Silvio; Benovic, Jeffrey L; Duncan, James S; Aplin, Andrew E.

J Biol Chem ; 299(12): 105418, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-37923138

7.

Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine receptor CXCR4.

Luo, Jiansong; De Pascali, Francesco; Richmond, G Wendell; Khojah, Amer M; Benovic, Jeffrey L.

J Biol Chem ; 298(2): 101551, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34973340

8.

G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin.

Varney, Matthew J; Steyaert, Wouter; Coucke, Paul J; Delanghe, Joris R; Uehling, David E; Joseph, Babu; Marcellus, Richard; Al-Awar, Rima; Benovic, Jeffrey L.

J Biol Chem ; 298(10): 102421, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-36030052

9.

Pepducin ICL1-9-Mediated ß2-Adrenergic Receptor-Dependent Cardiomyocyte Contractility Occurs in a G_i Protein/ROCK/PKD-Sensitive Manner.

Okyere, Ama Dedo; Song, Jianliang; Patwa, Viren; Carter, Rhonda L; Enjamuri, Nitya; Lucchese, Anna Maria; Ibetti, Jessica; de Lucia, Claudio; Schumacher, Sarah M; Koch, Walter J; Cheung, Joseph Y; Benovic, Jeffrey L; Tilley, Douglas G.

Cardiovasc Drugs Ther ; 37(2): 245-256, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-34997361

10.

Emerging Paradigm of Intracellular Targeting of G Protein-Coupled Receptors.

Chaturvedi, Madhu; Schilling, Justin; Beautrait, Alexandre; Bouvier, Michel; Benovic, Jeffrey L; Shukla, Arun K.

Trends Biochem Sci ; 43(7): 533-546, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29735399

11.

PD 102807 Induces M3 mAChR-Dependent GRK-/Arrestin-Biased Signaling in Airway Smooth Muscle Cells.

Tompkins, Eric; Mimic, Bogdana; Cuevas-Mora, Karina; Schorsch, Hannah; Shah, Sushrut D; Deshpande, Deepak A; Benovic, Jeffrey L; Penn, Raymond B; Pera, Tonio.

Am J Respir Cell Mol Biol ; 67(5): 550-561, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-35944139

12.

Phenylalanine 193 in Extracellular Loop 2 of the ß ₂-Adrenergic Receptor Coordinates ß-Arrestin Interaction.

Ippolito, Michael; De Pascali, Francesco; Inoue, Asuka; Benovic, Jeffrey L.

Mol Pharmacol ; 101(2): 87-94, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34853152

13.

Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.

Pera, Tonio; Deshpande, Deepak A; Ippolito, Michael; Wang, Bin; Gavrila, Adelina; Michael, James V; Nayak, Ajay P; Tompkins, Eric; Farrell, Eleni; Kroeze, Wesley K; Roth, Bryan L; Panettieri, Reynold A; Benovic, Jeffrey L; An, Steven S; Dulin, Nickolai O; Penn, Raymond B.

FASEB J ; 32(2): 862-874, 2018 02.

Artigo em Inglês | MEDLINE | ID: mdl-29042451

14.

G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel.

Lagman, Joann; Sayegh, Paula; Lee, Christina S; Sulon, Sarah M; Jacinto, Alec Z; Sok, Vanessa; Peng, Natalie; Alp, Deniz; Benovic, Jeffrey L; So, Christopher H.

Mol Cell Biochem ; 461(1-2): 103-118, 2019 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-31363957

15.

ß-arrestin-biased signaling through the ß2-adrenergic receptor promotes cardiomyocyte contraction.

Carr, Richard; Schilling, Justin; Song, Jianliang; Carter, Rhonda L; Du, Yang; Yoo, Sungsoo M; Traynham, Christopher J; Koch, Walter J; Cheung, Joseph Y; Tilley, Douglas G; Benovic, Jeffrey L.

Proc Natl Acad Sci U S A ; 113(28): E4107-16, 2016 07 12.

Artigo em Inglês | MEDLINE | ID: mdl-27354517

16.

G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans.

Wang, Jianjun; Luo, Jiansong; Aryal, Dipendra K; Wetsel, William C; Nass, Richard; Benovic, Jeffrey L.

J Biol Chem ; 292(14): 5943-5956, 2017 04 07.

Artigo em Inglês | MEDLINE | ID: mdl-28213524

17.

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

Sosa, Maria Soledad; Lopez-Haber, Cynthia; Yang, Chengfeng; Wang, Hongbin; Lemmon, Mark A; Busillo, John M; Luo, Jiansong; Benovic, Jeffrey L; Klein-Szanto, Andres; Yagi, Hiroshi; Gutkind, J Silvio; Parsons, Ramon E; Kazanietz, Marcelo G.

Mol Cell ; 40(6): 877-92, 2010 Dec 22.

Artigo em Inglês | MEDLINE | ID: mdl-21172654

18.

G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of ß-Arrestin.

Luo, Jiansong; Busillo, John M; Stumm, Ralf; Benovic, Jeffrey L.

Mol Pharmacol ; 91(6): 554-566, 2017 06.

Artigo em Inglês | MEDLINE | ID: mdl-28331048

19.

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the ß2-Adrenergic Receptor.

Tian, Xufan; Irannejad, Roshanak; Bowman, Shanna L; Du, Yang; Puthenveedu, Manojkumar A; von Zastrow, Mark; Benovic, Jeffrey L.

J Biol Chem ; 291(28): 14510-25, 2016 Jul 08.

Artigo em Inglês | MEDLINE | ID: mdl-27226565

20.

c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes.

DeRita, Rachel M; Zerlanko, Brad; Singh, Amrita; Lu, Huimin; Iozzo, Renato V; Benovic, Jeffrey L; Languino, Lucia R.

J Cell Biochem ; 118(1): 66-73, 2017 01.

Artigo em Inglês | MEDLINE | ID: mdl-27232975

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