Detalhe da pesquisa
1.
Allosteric modulation of metabotropic glutamate receptors by chloride ions.
FASEB J
; 29(10): 4174-88, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26116702
2.
Novel Inhibitory Site Revealed by XAP044 Mode of Action on the Metabotropic Glutamate 7 Receptor Venus Flytrap Domain.
J Med Chem
; 2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38691510
3.
Successful prediction of substrate-binding pocket in SLC17 transporter sialin.
J Biol Chem
; 287(14): 11489-97, 2012 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22334707
4.
A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential.
FASEB J
; 26(4): 1682-93, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22223752
5.
Protein-ligand-based pharmacophores: generation and utility assessment in computational ligand profiling.
J Chem Inf Model
; 52(4): 943-55, 2012 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22480372
6.
Predicting fragment binding poses using a combined MCSS MM-GBSA approach.
J Chem Inf Model
; 51(5): 1092-105, 2011 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21528911
7.
Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach.
Bioorg Med Chem Lett
; 20(18): 5552-8, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20692832
8.
Asc-1 Transporter (SLC7A10): Homology Models And Molecular Dynamics Insights Into The First Steps Of The Transport Mechanism.
Sci Rep
; 10(1): 3731, 2020 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32111919
9.
Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin.
J Med Chem
; 63(15): 8231-8249, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32608236
10.
LSP5-2157 a new inhibitor of vesicular glutamate transporters.
Neuropharmacology
; 164: 107902, 2020 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31811873
11.
Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.
J Med Chem
; 61(5): 1969-1989, 2018 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29397723
12.
Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists.
J Med Chem
; 50(15): 3585-95, 2007 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17602546
13.
Molecular determinants of ligand selectivity in a vertebrate odorant receptor.
J Neurosci
; 24(45): 10128-37, 2004 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-15537883
14.
Virtual screening workflow development guided by the "receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.
J Med Chem
; 48(7): 2534-47, 2005 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15801843
15.
Common and selective molecular determinants involved in metabotopic glutamate receptor agonist activity.
J Med Chem
; 45(15): 3171-83, 2002 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12109902
16.
Structure-based virtual screening: an application to human topoisomerase II alpha.
J Med Chem
; 47(27): 6840-53, 2004 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15615533
17.
Molecular determinants of agonist selectivity in glutamate-gated chloride channels which likely explain the agonist selectivity of the vertebrate glycine and GABAA-ρ receptors.
PLoS One
; 9(9): e108458, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25259865
18.
A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design.
Neuropharmacology
; 60(1): 102-7, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20621106
19.
Odorant receptor specificities and receptor combinatorials: implications for olfactory coding.
Chem Senses
; 30 Suppl 1: i97-8, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15738215
20.
A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.
J Med Chem
; 53(7): 2797-813, 2010 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20218620