Detalhe da pesquisa
1.
Towards a platform quantitative systems pharmacology (QSP) model for preclinical to clinical translation of antibody drug conjugates (ADCs).
J Pharmacokinet Pharmacodyn
; 2023 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37787918
2.
A next generation mathematical model for the in vitro to clinical translation of T-cell engagers.
J Pharmacokinet Pharmacodyn
; 50(3): 215-227, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36790614
3.
Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM1.
J Pharmacokinet Pharmacodyn
; 47(5): 513-526, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32710210
4.
Establishing in vitro-in vivo correlation for antibody drug conjugate efficacy: a PK/PD modeling approach.
J Pharmacokinet Pharmacodyn
; 45(2): 339-349, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29423862
5.
On translation of antibody drug conjugates efficacy from mouse experimental tumors to the clinic: a PK/PD approach.
J Pharmacokinet Pharmacodyn
; 40(5): 557-71, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23933716
6.
Therapeutic index improvement of antibody-drug conjugates.
MAbs
; 15(1): 2230618, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37408311
7.
Bench to bedside translation of antibody drug conjugates using a multiscale mechanistic PK/PD model: a case study with brentuximab-vedotin.
J Pharmacokinet Pharmacodyn
; 39(6): 643-59, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23151991
8.
Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human.
J Pharmacokinet Pharmacodyn
; 39(1): 67-86, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22143261
9.
Palaeoenvironmental proxies indicate long-term development of agro-pastoralist landscapes in Inner Asian mountains.
Sci Rep
; 12(1): 554, 2022 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35017595
10.
Quantitative systems pharmacology modeling provides insight into inter-mouse variability of Anti-CTLA4 response.
CPT Pharmacometrics Syst Pharmacol
; 11(7): 880-893, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35439371
11.
New evidence for supplementary crop production, foddering and fuel use by Bronze Age transhumant pastoralists in the Tianshan Mountains.
Sci Rep
; 11(1): 13718, 2021 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34215794
12.
Quantitative modeling predicts competitive advantages of a next generation anti-NKG2A monoclonal antibody over monalizumab for the treatment of cancer.
CPT Pharmacometrics Syst Pharmacol
; 10(3): 220-229, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33501768
13.
Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors.
MAbs
; 13(1): 1850395, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33459147
14.
The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis.
J Pharmacol Exp Ther
; 333(1): 2-13, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20089807
15.
Pharmacokinetics and elucidation of the rates and routes of N-glucuronidation of PF-592379, an oral dopamine 3 agonist in rat, dog, and human.
Xenobiotica
; 40(11): 730-42, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20836725
16.
Mechanistic Quantitative Pharmacology Strategies for the Early Clinical Development of Bispecific Antibodies in Oncology.
Clin Pharmacol Ther
; 108(3): 528-541, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32579234
17.
Seasonal movements of Bronze Age transhumant pastoralists in western Xinjiang.
PLoS One
; 15(11): e0240739, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33147229
18.
In vitro and in vivo SAR of pyrido[3,4-d]pyramid-4-ylamine based mGluR1 antagonists.
Bioorg Med Chem Lett
; 19(8): 2190-4, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19289283
19.
A Physiologically-Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data.
CPT Pharmacometrics Syst Pharmacol
; 8(10): 738-747, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31464379
20.
Correction to: A Translational Quantitative Systems Pharmacology Model for CD3 Bispecific Molecules: Application to Quantify T Cell-Mediated Tumor Cell Killing by P-Cadherin LP DART®.
AAPS J
; 21(4): 73, 2019 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31165304