RESUMO
We report the clinical features of five patients with lumbosacral radiculoplexopathy (LSRP) and one patient with a femoral neuropathy, all of whom had serologic evidence of a recent Epstein-Barr virus (EBV) infection. After a thorough investigation, no other etiology was apparent. Pain was a prominent feature in all cases, and the prognosis was generally good, with recovery in weeks to months. We conclude that LSRP may occur as a postinfectious process following recent EBV infection.
Assuntos
Herpesvirus Humano 4 , Mononucleose Infecciosa/complicações , Plexo Lombossacral , Raízes Nervosas Espinhais , Adulto , Idoso , Reações Antígeno-Anticorpo , Antígenos Virais/análise , Eletrofisiologia , Feminino , Nervo Femoral , Herpesvirus Humano 4/imunologia , Humanos , Masculino , Pessoa de Meia-Idade , Doenças do Sistema Nervoso Periférico/etiologia , Doenças do Sistema Nervoso Periférico/imunologia , Doenças do Sistema Nervoso Periférico/fisiopatologiaRESUMO
IgG autoantibodies present in the serum of pemphigus vulgaris and bullous pemphigoid patients were detected by a solid phase radioimmunoassay, using a squamous cell tumour line, SCaBER, as substrate. This preliminary study shows that the SCaBER cell line displays both pemphigus and bullous pemphigoid antigens. This source of antigens should allow the development of a sensitive assay to measure anti-ICS and anti-BMZ antibodies. Such an assay may have clinical applications and may provide an important tool for studying the mechanisms of autoantibody production in pemphigus and pemphigoid.
Assuntos
Autoanticorpos/análise , Penfigoide Bolhoso/imunologia , Pênfigo/imunologia , Dermatopatias Vesiculobolhosas/imunologia , Adesivos/análise , Antígenos de Neoplasias/imunologia , Membrana Basal/imunologia , Carcinoma de Células Escamosas/imunologia , Linhagem Celular , Humanos , Imunoglobulina G/análise , Radioimunoensaio , Neoplasias da Bexiga Urinária/imunologiaRESUMO
Pemphigus antibodies of class G immunoglobulins (IgG) were studied with the use of a solid-phase radioimmunoassay (RIA) that utilizes COLO-16, a squamous cell tumor line, as the substrate. Sera from patients with pemphigus vulgaris and pemphigus vegetans showed greater average binding than did sera from patients with pemphigus foliaceus and pemphigus erythematosus. The patients were subgrouped according to their clinical presentations and were divided into patients with skin lesions only, those with mucous membrane lesions only, and those with both skin and mucous membrane lesions. No significant differences were observed between these groups. There was good correlation between IgG binding in the RIA and both the disease activity and the response to therapy. Blood group antigen absorbable "false positive" anti-intercellular substance antibodies were not detected in the RIA.