Detalhe da pesquisa
1.
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Nature
; 508(7495): 258-62, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24717514
2.
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.
Nature
; 510(7506): 542-6, 2014 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24847880
3.
Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism.
Proc Natl Acad Sci U S A
; 113(24): E3423-30, 2016 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27247419
4.
Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents.
Diabetologia
; 61(6): 1435-1446, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29497783
5.
Factor XI antisense oligonucleotide for prevention of venous thrombosis.
N Engl J Med
; 372(3): 232-40, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25482425
6.
Second-generation antisense oligonucleotides against ß-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance.
FASEB J
; 30(3): 1207-17, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26644352
7.
Integrated Safety Assessment of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers.
Mol Ther
; 24(10): 1771-1782, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27357629
8.
Population pharmacokinetics and pharmacodynamics of IONIS-GCGRRx, an antisense oligonucleotide for type 2 diabetes mellitus: a red blood cell lifespan model.
J Pharmacokinet Pharmacodyn
; 44(3): 179-191, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28132162
9.
Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo.
Proc Natl Acad Sci U S A
; 110(31): 12780-5, 2013 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23840067
10.
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance.
Proc Natl Acad Sci U S A
; 110(5): 1869-74, 2013 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-23302688
11.
ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content.
J Lipid Res
; 56(3): 526-536, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25548259
12.
A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis.
J Biol Chem
; 289(11): 7257-63, 2014 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24497630
13.
Factor XI regulates pathological thrombus formation on acutely ruptured atherosclerotic plaques.
Arterioscler Thromb Vasc Biol
; 34(8): 1668-73, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24947525
14.
cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis.
J Biol Chem
; 288(22): 16167-76, 2013 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23595987
15.
Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats.
Am J Physiol Endocrinol Metab
; 307(9): E773-83, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25159329
16.
FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress.
Am J Physiol Endocrinol Metab
; 307(1): E34-46, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24824652
17.
Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats.
Hepatology
; 57(5): 1763-72, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23175050
18.
Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins.
Nat Med
; 13(2): 171-80, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17273170
19.
Safety and Tolerability of GalNAc3-Conjugated Antisense Drugs Compared to the Same-Sequence 2'-O-Methoxyethyl-Modified Antisense Drugs: Results from an Integrated Assessment of Phase 1 Clinical Trial Data.
Nucleic Acid Ther
; 34(1): 18-25, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38227794
20.
Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice.
Cell Commun Signal
; 11: 49, 2013 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23889985