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1.
Science ; 369(6502)2020 07 24.
Artigo em Inglês | MEDLINE | ID: mdl-32703849

RESUMO

Smallpox, one of the most devastating human diseases, killed between 300 million and 500 million people in the 20th century alone. We recovered viral sequences from 13 northern European individuals, including 11 dated to ~600-1050 CE, overlapping the Viking Age, and reconstructed near-complete variola virus genomes for four of them. The samples predate the earliest confirmed smallpox cases by ~1000 years, and the sequences reveal a now-extinct sister clade of the modern variola viruses that were in circulation before the eradication of smallpox. We date the most recent common ancestor of variola virus to ~1700 years ago. Distinct patterns of gene inactivation in the four near-complete sequences show that different evolutionary paths of genotypic host adaptation resulted in variola viruses that circulated widely among humans.


Assuntos
Varíola , Vírus da Varíola , Evolução Biológica , Europa (Continente) , Genoma Viral , História Medieval , Humanos , Varíola/história , Varíola/virologia , Vírus da Varíola/genética
2.
Philos Trans R Soc Lond B Biol Sci ; 370(1660): 20130384, 2015 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-25487335

RESUMO

The medieval Norsemen or Vikings had an important biological and cultural impact on many parts of Europe through raids, colonization and trade, from about AD 793 to 1066. To help understand the genetic affinities of the ancient Norsemen, and their genetic contribution to the gene pool of other Europeans, we analysed DNA markers in Late Iron Age skeletal remains from Norway. DNA was extracted from 80 individuals, and mitochondrial DNA polymorphisms were detected by next-generation sequencing. The sequences of 45 ancient Norwegians were verified as genuine through the identification of damage patterns characteristic of ancient DNA. The ancient Norwegians were genetically similar to previously analysed ancient Icelanders, and to present-day Shetland and Orkney Islanders, Norwegians, Swedes, Scots, English, German and French. The Viking Age population had higher frequencies of K*, U*, V* and I* haplogroups than their modern counterparts, but a lower proportion of T* and H* haplogroups. Three individuals carried haplotypes that are rare in Norway today (U5b1b1, Hg A* and an uncommon variant of H*). Our combined analyses indicate that Norse women were important agents in the overseas expansion and settlement of the Vikings, and that women from the Orkneys and Western Isles contributed to the colonization of Iceland.


Assuntos
DNA Mitocondrial/genética , Fósseis , Marcadores Genéticos/genética , Variação Genética , Migração Humana/história , Sequência de Bases , Osso e Ossos/química , DNA Mitocondrial/história , Feminino , Haplótipos/genética , História Medieval , Humanos , Dados de Sequência Molecular , Noruega , Técnicas de Amplificação de Ácido Nucleico , Alinhamento de Sequência , Análise de Sequência de DNA , Dente/química
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