Update on the use of long-acting growth hormone in children.

PURPOSE OF REVIEW: After extensive research and many years of waiting, long-acting growth hormone (LAGH) formulations have finally become a reality in clinical practice and emerge as a potential solution to address the challenges of daily injections of recombinant human GH (rhGH). In this review, we present a brief history of the development of LAGH and provide a critical analysis of the existing literature on the five LAGH available and approved to date for treatment in children. RECENT FINDINGS: In clinical trials, LAGH therapy has shown noninferiority compared with daily rhGH therapy in promoting linear growth in children with GH deficiency, with similar rates of adverse events. SUMMARY: In the real world, many questions still need to be answered, such as whether a specific group of patients will benefit most from the weekly injection, whether compliance will be better compared with daily rhGH, whether long-term efficacy, monitoring and safety profile will be the same for the different LAGH compounds, and whether the cost-effectiveness will justify their use in different settings.

The challenge of long-term follow-up of survivors of childhood acute leukemia after hematopoietic stem cell transplantation in resource-limited countries: A single-center report from Brazil.

With the number of long-term HSCT survivors steadily increasing, attention needs to be focused on the late complications and quality of life. We therefore analyzed the outcome of 101 pediatric patients (<18 years old at the time of HSCT) transplanted for acute leukemia between 1981 and 2015 at Complexo Hospital de Clínicas, Federal University of Paraná, Brazil, and who survived at least two years after HSCT. The median follow-up was 5.9 years (2.0-29.0); median age at follow-up was 17.5 years (2.98-39.0). The 5-year cumulative incidence of relapse was 27.5% (95% CI 18.6%-36.4%). Two-year cumulative incidence of chronic GVHD was 21.8% (95% CI 13.7%-29.8%). Of the 101 patients, 72 patients (71.3%) presented with late effects. Those surviving longer after HSCT experienced more complications. Patients who received TBI-based regimen developed more late effects (P = .013) and more endocrinological complications (P = .024). Endocrinological complications were the most common late sequelae found in this study. For childhood survivors, quality of life was not influenced by age (at HSCT or at last visit), time from HSCT, gender, donor, or GVHD. For survivors that no longer were children, only age at last visit impacted financial domain measures, irrespective of gender, donor, or GVHD. The current study confirms the high burden late complications after pediatric HSCT have on the survivors and underlines the importance of extended follow-up.

The science behind the relations among cancer, height, growth patterns, and growth hormone axis.

The association between growth hormone (GH) and carcinogenesis has long been postulated. The rationale for this association is that several components of the GH axis play an important role in the regulation of cell proliferation, differentiation, apoptosis, and angiogenesis and have been tested as targets for cancer therapy. Epidemiological and clinical studies have examined the association between height, growth patterns, and insulin-like growth factor 1 (IGF1) levels with the most common types of malignancies, while genome-wide association studies have revealed several height-associated genes linked to cancer and/or metastasis-driving pathways. In this context, a permissive role of the GH-IGF signaling system in the link between height and cancer risk has also been investigated. In animal and human models, genetic defects associated with GH deficiency or resistance are associated with protection from tumor development, while the risk of malignancies in acromegaly or in patients exposed to recombinant GH therapy has long been a matter of concern and scrutiny. In this review, we present a narrative and historical review covering the potential relations among height, growth patterns, GH axis, and cancer.

From dwarves to giants: South American's contribution to the history of growth hormone and related disorders.

The aim of this article is to present a historical review on giants and dwarves living in South America and the contribution of South America's researchers to scientific advances on growth hormone (GH) and human disorders related to GH excess and GH deficiency (GHD). We went back in time to investigate facts and myths stemming from countless reports of giants who lived in the Patagonia region, focusing on what is currently known about gigantism in South America. Additionally, we have reviewed the exceptional work carried out in two of the world's largest cohorts of dwarfism related to GH-IGF axis: one living in Itabaianinha, Brazil, suffering from severe GHD due to a mutation in the GHRH receptor (GHRHR) gene, and the other living in El Oro and Loja provinces of Ecuador, who are carriers of GH receptor gene mutation that causes total GH insensitivity (Laron syndrome). Importantly, we present an overview of the outstanding medical contribution of Jose Dantas de Souza Leite, a Brazilian physician that described the first cases of acromegaly, and Bernardo Alberto Houssay, an Argentine researcher graced with the Nobel Prize, who was one the first scientists to establish a link between GH and glucose metabolism.

Growth Hormone's Links to Cancer.

Several components of the GH axis are involved in tumor progression, and GH-induced intracellular signaling has been strongly associated with breast cancer susceptibility in genome-wide association studies. In the general population, high IGF-I levels and low IGF-binding protein-3 levels within the normal range are associated with the development of common malignancies, and components of the GH-IGF signaling system exhibit correlations with clinical, histopathological, and therapeutic parameters in cancer patients. Despite promising findings in preclinical studies, anticancer therapies targeting the GH-IGF signaling system have led to disappointing results in clinical trials. There is substantial evidence for some degree of protection against tumor development in several animal models and in patients with genetic defects associated with GH deficiency or resistance. In contrast, the link between GH excess and cancer risk in acromegaly patients is much less clear, and cancer screening in acromegaly has been a highly controversial issue. Recent studies have shown that increased life expectancy in acromegaly patients who attain normal GH and IGF-I levels is associated with more deaths due to age-related cancers. Replacement GH therapy in GH deficiency hypopituitary adults and short children has been shown to be safe when no other risk factors for malignancy are present. Nevertheless, the use of GH in cancer survivors and in short children with RASopathies, chromosomal breakage syndromes, or DNA-repair disorders should be carefully evaluated owing to an increased risk of recurrence, primary cancer, or second neoplasia in these individuals.

Physical activity, eating and sleep in athletes one year after the covid-19 pandemic / Actividad física, alimentación y sueño en atletas después de un año de la pandemia del covid-19 / Atividade física, alimentação e sono em atletas após um ano da pandemia de covid-19

ABSTRACT Introduction: The pandemic caused by COVID-19 has resulted in worrying effects related to the "new" habits adopted by the population. The long period of school closures and social isolation have profoundly impacted the learning, health, and protection of children and adolescents. Objective: To re-evaluate school athletes quarantined by COVID-19, highlighting the main physical activity (PA), eating and sleeping habits, and the implications related to physical and mental health after one year of the pandemic in the city of Curitiba, Brazil. Methods: Two surveys were conducted, 342 attended the first assessment, and 222 attended the second. An online questionnaire (Google docs) was applied to the students, consisting of 18 closed and open questions in the first moment (beginning of the pandemic) and 22 at the second moment (after one year of the pandemic). Results: Half of the students (53.2%; 57%) reported eating up to three meals daily. With regard to sleeping hours, the majority of students (80%; 79.5%) were able to sleep at night between 6:00 and 10:00. There was a significant decrease in the time spent on social networks, migrating to school activities (p <0.005). Approximately a quarter of the student-athletes (27%) practiced PA every day and felt fulfilled in the first assessment, and in the second assessment, this number increased to 43% (p = 0.009). Conclusion: Despite the decrease in screen time and the increase in regular PA, there was an increase in body weight in more than a third of the athletes evaluated. Those who maintained their body weight maintained healthier lifestyles with several meals within the recommended range and slept 6 to 10 hours per night. Level of Evidence III; Retrospective comparative study.

RESUMEN Introducción: La pandemia provocada por el COVID-19 trajo efectos preocupantes relacionados con los "nuevos" hábitos adoptados por la población. El largo período de cierre de escuelas y aislamiento social ha impactado profundamente en el aprendizaje, la salud y la protección de niños, niñas y adolescentes. Objetivo: Reevaluar atletas escolares sometidos a cuarentena por COVID-19, destacando los principales hábitos de actividad física (AF), alimentación y sueño y las implicaciones relacionadas con la salud física y mental después de un año de pandemia en la ciudad de Curitiba, Brasil. Métodos: Se realizaron dos encuestas, 342 asistieron a la primera evaluación y 222 a la segunda. Se aplicó un cuestionario en línea (Google docs) a los estudiantes, compuesto por 18 preguntas cerradas y abiertas en el primer momento (inicio de la pandemia) y 22 en el segundo momento (después de un año de pandemia). Resultados: La mitad de los estudiantes (53,2%; 57%) refirió tener hasta tres comidas al día. En cuanto al tiempo de sueño, la mayoría de los estudiantes (80%; 79,5%) pudo dormir por la noche entre las 6:00 y las 10:00. Hubo una disminución significativa en el tiempo dedicado a las redes sociales, migrando a las actividades escolares (p <0,005). Aproximadamente una cuarta parte de los estudiantes deportistas (27%) practicaban AF todos los días y se sentían realizados en la primera evaluación, y en la segunda evaluación este número aumentó al 43% (p = 0,009). Conclusión: A pesar de la disminución del tiempo de pantalla y del aumento de la AF regular, hubo un aumento del peso corporal en más de un tercio de los atletas evaluados. Los que mantuvieron su peso corporal fueron aquellos que mantuvieron estilos de vida más saludables con varias comidas dentro del rango recomendado y que dormían de 6 a 10 horas por noche. Nivel de Evidencia III; Estudio comparativo retrospectivo.

RESUMO Introdução: A pandemia provocada pelo COVID-19 resultou em efeitos preocupantes relacionados aos "novos" hábitos adotados pela população. O longo período de fechamento das escolas e o isolamento social têm impactado profundamente a aprendizagem, a saúde e a proteção de crianças e adolescentes. Objetivo: Reavaliar atletas escolares submetidos à quarentena por COVID-19, destacando os principais hábitos de atividade física (AF), alimentação e sono e as implicações relacionadas à saúde física e mental após um ano de pandemia na cidade de Curitiba, Brasil. Métodos: Foram realizadas duas pesquisas, 342 compareceram à primeira avaliação e 222 à segunda. Foi aplicado aos alunos um questionário online (Google docs), composto por 18 questões fechadas e abertas no primeiro momento (início da pandemia) e 22 no segundo momento (após um ano de pandemia). Resultados: Metade dos alunos (53,2%; 57%) relatou fazer até três refeições ao dia. Quanto ao horário de sono, a maioria dos alunos (80%; 79,5%) conseguiu dormir à noite entre 6h00 e 10h00. Houve diminuição significativa do tempo gasto nas redes sociais, migrando para atividades escolares (p <0,005). Aproximadamente um quarto dos alunos atletas (27%) praticava AF todos os dias e se sentiu realizado na primeira avaliação, e na segunda avaliação esse número aumentou para 43% (p = 0,009). Conclusão: Apesar da diminuição do tempo de tela e do aumento da AF regular, houve aumento do peso corporal em mais de um terço dos atletas avaliados. Os que mantiveram o peso corporal foram os que mantiveram estilos de vida mais saudáveis com várias refeições dentro da faixa recomendada e que dormiam de 6 a 10 horas por noite. Nível de Evidência III; Estudo retrospectivo comparativo.

MANAGEMENT OF ENDOCRINE DISEASE: Growth and growth hormone therapy in short children born preterm.

Approximately 15 million babies are born preterm across the world every year, with less than 37 completed weeks of gestation. Survival rates increased during the last decades with the improvement of neonatal care. With premature birth, babies are deprived of the intense intrauterine growth phase, and postnatal growth failure might occur. Some children born prematurely will remain short at later ages and adult life. The risk of short stature increases if the child is also born small for gestational age. In this review, the effects of being born preterm on childhood growth and adult height and the hormonal abnormalities possibly associated with growth restriction are discussed, followed by a review of current information on growth hormone treatment for those who remain with short stature during infancy and childhood.

Growth hormone, insulin-like growth factor system and carcinogenesis.

The growth hormone (GH) and insulin-like growth factor (IGF) system plays an important role in the regulation of cell proliferation, differentiation, apoptosis, and angiogenesis. In terms of cell cycle regulation, the GH-IGF system induces signalling pathways for cell growth that compete with other signalling systems that result in cell death; thus the final effect of these opposed forces is critical for normal and abnormal cell growth. The association of the GH-IGF system with carcinogenesis has long been hypothesised, mainly based on in vitro studies and the use of a variety of animal models of human cancer, and also on epidemiological and clinical evidence in humans. While ample experimental evidence supports a role of the GH-IGF system in tumour promotion and progression, with several of its components being currently tested as central targets for cancer therapy, the strength of evidence from patients with acromegaly, GH deficiency, or treated with GH is much weaker. In this review, we will attempt to consolidate this data. (Endokrynol Pol 2016; 67 (4): 414-426).

The influence of glycemic control on the oral health of children and adolescents with diabetes mellitus type 1.

OBJECTIVE: To evaluate the influence of disease control, expressed by the mean values of glycated hemoglobin (HbA1c), in the oral health of children and adolescents with diabetes mellitus type 1 (T1DM). SUBJECTS AND METHODS: A cross sectional study involving 87 children and adolescents (59 girls), 10 ± 2.6 years old. The participants were divided into three groups: HbA1c ≤ 8%, 8% < HbA1c ≤ 10% and HbA1c > 10%. The duration of the disease, age and average HbA1c were obtained from their medical records. Oral health was evaluated according to the following indexes: Simplified Oral Hygiene Index (OHI-S); Community Periodontal Index (CPI); Decayed, Missing or Filled Teeth Index (DMFT/dmft) for permanent and deciduous teeth; and the stimulated salivary flow rate (SSFR). RESULTS: The median SSFR was 1.1 mL/min in the group with HbA1c ≤ 8%, 0.7 mL/min in the intermediary group and 0.6 mL/min in the HbA1c > 10% group. A significant decrease in salivary flow was observed with an increase in HbA1c (p = 0.007). The DMFT/dmft and CPI indexes were higher in individuals with higher HbA1c values. More caries-free individuals were found in the group with HbA1c ≤ 8% compared to those with HbA1c > 10%. The group with HbA1c > 10% exhibited more caries and bleeding gums than the other groups. HbA1c values in girls were higher than in boys. CONCLUSION: Children and adolescents with unsatisfactory glycemic control, represented by higher HbA1c concentrations, exhibited a higher frequency of caries and gingivitis, and a reduction in salivary flow.

[Metabolic syndrome in adolescents of different nutritional status]. / Síndrome metabólica em adolescentes de diferentes estados nutricionais.

OBJECTIVE: To investigate the prevalence of metabolic syndrome (MetS) in adolescents of different nutritional status. SUBJECTS AND METHODS: The sample consisted of 582 adolescents aged 12 to 18 years. Body mass index (BMI) classification of nutritional status was performed using the NCHS growth charts. MetS diagnosis was determined by the presence of three or more risk factors. RESULTS: Overall MetS prevalence was 6.7% (CI: 4.9%-9%); in boys, prevalence was 9.4%; and in girls, 4.1%. MetS prevalence was 17.2% (CI: 10%-28.2%) and 37.1% (CI: 23.2%-53.7%) in overweight and obese adolescents, respectively. All obese adolescents had at least one risk factor present, and demonstrated high MetS prevalence ratio compared with adolescents of normal weight (PR: 11.1; CI: 5.75-21.47). CONCLUSION: High prevalence of MetS was observed in obese adolescents. Prevention strategies should focus on body weight control since the beginning of adolescence.

[Assessment of diastolic function in children and adolescents with type 1 diabetes mellitus - are there early signs of diabetic cardiomyopathy?]. / Avaliação da função diastólica em crianças e adolescentes diabéticos tipo 1 - Existem sinais precoces de miocardiopatia diabética?

OBJECTIVES: To evaluate diastolic function (DF) of children and adolescents with type 1 diabetes mellitus (DM1). SUBJECTS AND METHODS: Cross-sectional study of 67 otherwise healthy diabetic patients, and a control group (n = 84) in regard to age, sex, body mass index (BMI), Dopplere-chocardiography, and ECG for both groups; and disease duration, HbA1C, microalbuminuria, and serum lipids for DM 1 patients. RESULTS: Diastolic alterations [(A and E mitral waves, E/A ratio, isovolumic relaxation time (IVRT) and E wave deceleration time (EWDT)] were found in diabetic patients, with higher prevalence among pubertal girls (13-17 years old). IVRT and EWDT correlated positively with BMI (p = 0.028). Chronological age and disease duration were predictive factors for mitral A wave (p = 0.004 and 0.033, respectively). CONCLUSIONS: DF alterations were detected in the group of diabetic patients, with greater prevalence among pubertal girls; disease duration and age influenced parameters of DF.

[Growth of preterm-born children]. / Crescimento de crianças nascidas prematuras.

Children born prematurely might experience a period of growth restriction just after birth. Catch-up growth begins during the first months of life and can be slow and progressive. These children may remain shorter and thinner throughout infancy and childhood compared to children born at term. In some cases, complete catch-up growth occurs only during adolescence. However, some children do not completely recover growth, and adults born prematurely are at increased risk of short stature. Impaired growth is more frequent in those born preterm and small for gestational age. Factors such as target height, birth weight, gestational age, neonatal morbidities and maternal education interfere in growth potential. Special attention should be given to children born preterm during the whole growth period.

[Final height (FH) in Turner syndrome (TS): experience of 76 cases followed at the Pediatric Endocrinology Unit, Hospital de Clinicas, Federal University of Paraná]. / Estatura final (EF) em síndrome de Turner (ST): experiência de 76 casos acompanhados na Unidade de Endocrinologia Pediátrica do Hospital de Clínicas da Universidade Federal do Paraná

OBJECTIVE: To report the final height (FH) of 76 patients with Turner syndrome (TS). MATERIALS AND METHODS: Review of the files and calculation of z scores: of target height (TH), and FH according to NCHS/CDC/2000 and FH according to Lyon and cols. RESULTS: Patients were classified in three groups: A (n = 16), treatment with estrogens and progestogens; B (n = 21), treatment with oxandrolone (OX); C (n = 39), growth hormone (GH) plus OX. The z score of TH was not different among the groups and z score of FH was not different between A e B. Z score of FH of group C was greater than the other groups, > 2SDS of Lyon's curve and fitted on the 3(rd) percentile of NCHS/CDC. Multiple regression analysis showed type of treatment (p < 0.001) and maternal height (p = 0.02) as most influencing factors on FH. CONCLUSION: GH plus OX and maternal height contributed significantly to enhance FH of TS patients.

Use of physical activity and cardiorespiratory fitness in identifying cardiovascular risk factors in male Brazilian adolescents / Uso da atividade física e da aptidão cardiorrespiratória na identificação de fatores de risco cardiovasculares em adolescentes Brasileiros

Abstract The aim of this study was to investigate the impact of physical activity (PA) and cardiorespiratory fitness (CRF) levels on the prevalence of overweight and high blood pressure levels in adolescents. In this observational, cross-sectional study, 614 boys aged 10-14 years were assessed for height, body mass, body mass index (BMI), waist circumference (WC) and blood pressure (BP). CRF was assessed using a run test (Léger Test) and subjects were then grouped according to their CRF level. PA level was assessed through a questionnaire (The Three Day Physical Activity Recall) and classified into two groups, namely ≥ 300 minutes of PA/week and < 300 minutes of PA/week. Maturational stage was evaluated according to the development of pubic hair (self-assessment) as proposed by Tanner. We used statistical descriptive analysis, univariate and multivariate analyses in the total participants and subjects were divided by age. Fifty percent of the sample performed < 300 minutes of PA/week and 67.6% had unsatisfactory CRF levels. There was a higher prevalence of unsatisfactory CRF levels among subjects with altered BMI (overweight), WC (abdominal obesity) or BP (high blood pressure) for all age groups. PA history, however, did not show any significance. A total of 31% of participants were overweight, 24.8% had abdominal obesity and 15.4% had increased BP. Unsatisfactory CRF levels were found to be a better predictor for the diagnosis of cardiovascular diseases (CV) risk factors than PA history, regardless of age group.

Resumo Objetivou-se investigar o impacto da atividade física (AF) e níveis da aptidão cardiorrespiratória (APCR) na prevalência de excesso de peso e níveis hipertensivos em adolescentes. Estudo observacional, transversal, com 614 meninos de 10 a 14 anos, que foram avaliados quanto à estatura, massa corporal, índice de massa corporal (IMC), circunferência abdominal (CA) e pressão arterial (PA). Utilizou-se teste de corrida (Léger Test) para avaliar a APCR. O nível de AF foi avaliado por questionário (The Three Day Physical Activity Recall), classificando-os conforme prática < ou ≥ 300 minutos/semana. Estágio maturacional foi autoavaliado de acordo com o desenvolvimento dos pelos pubianos, proposto por Tanner. Testes estatísticos de análises descritivas, bivariada e multivariada foram utilizados. Do total, 50% dos escolares apresentaram AF < 300 minutos/semana e 67,6% com APCR insatisfatória. Indivíduos com alterações no IMC (excesso de peso), CA (obesidade abdominal) ou PA (valores hipertensivos) apresentaram maiores frequências de APCR insatisfatória em todas as faixas etárias, enquanto que o histórico de AF não se mostrou significativo. A APCR insatisfatória apresentou-se como melhor parâmetro para o diagnóstico de fatores de risco para doenças cardiovasculares (CV) do que o histórico de AF, independente da faixa etária.

The influence of glycemic control on the oral health of children and adolescents with diabetes mellitus type 1

ABSTRACT Objective To evaluate the influence of disease control, expressed by the mean values of glycated hemoglobin (HbA1c), in the oral health of children and adolescents with diabetes mellitus type 1 (T1DM). Subjects and methods A cross sectional study involving 87 children and adolescents (59 girls), 10 ± 2.6 years old. The participants were divided into three groups: HbA1c ≤ 8%, 8% < HbA1c ≤ 10% and HbA1c > 10%. The duration of the disease, age and average HbA1c were obtained from their medical records. Oral health was evaluated according to the following indexes: Simplified Oral Hygiene Index (OHI-S); Community Periodontal Index (CPI); Decayed, Missing or Filled Teeth Index (DMFT/dmft) for permanent and deciduous teeth; and the stimulated salivary flow rate (SSFR). Results The median SSFR was 1.1 mL/min in the group with HbA1c ≤ 8%, 0.7 mL/min in the intermediary group and 0.6 mL/min in the HbA1c > 10% group. A significant decrease in salivary flow was observed with an increase in HbA1c (p = 0.007). The DMFT/dmft and CPI indexes were higher in individuals with higher HbA1c values. More caries-free individuals were found in the group with HbA1c ≤ 8% compared to those with HbA1c > 10%. The group with HbA1c > 10% exhibited more caries and bleeding gums than the other groups. HbA1c values in girls were higher than in boys. Conclusion Children and adolescents with unsatisfactory glycemic control, represented by higher HbA1c concentrations, exhibited a higher frequency of caries and gingivitis, and a reduction in salivary flow. Arch Endocrinol Metab. 2015;59(6):535-40.

Weaning and associated factors in children from low-income communities / Fatores associados ao desmame em crianças de comunidades de baixa renda

Introduction: The average duration of breastfeeding is still insufficient and differ widely taking in account the location and specific characteristic of local people involved in these studies. Aim: This research aimed at studying factors associated to weaning among South Brazilian children living in a low-income household. Material and method: Cross-sectional study was carried out enrolling 124 mothers of 1 to 12-month-old children, who were interviewed at "Pastoral da Criança" (non-governmental organization) in Almirante Tamandaré, Paraná, Brazil. The risk of weaning considered was the dependent variable and the information collected from the questionnaires, independent variables. The method used to collect information in this study was Kaplan-Meier method and Cox regression model and Spearman's rank correlation (α = 0.05). Result: Actuarial life table presented a higher weaning conditional probability at 12 months of age, followed by first and fourth months of age. Multivariate analysis pointed out that contact with bottle feeding before the sixth month of age [HR=17.16 (2.34-125.86)] and contact with pacifier before the sixth months of age [HR=3.48 (1.90-6.38)] are risk factors associated with weaning. Among children who were not breastfed at the moment of the interview, breastfeeding duration presented a positive correlation with the ages when the children had their first contact with sugar (r s =+0.419, p=0.001) and negative correlation with the use of pacifier (r s =-0.300, p=0.017). Conclusion: Results from this study showed that the use of the feeding bottle and pacifier were related to a shorter breastfeeding time span at these communities. .

Introdução: A duração média do aleitamento materno ainda é insuficiente e apresenta grandes variações em razão do local e das características da população estudada. Objetivo: Analisar os fatores associados ao desmame em crianças sul brasileiras de comunidades de baixa renda. Material e método: Estudo transversal realizado através de entrevista envolvendo 124 mães de crianças com até 12 meses de idade, atendidas pela Pastoral da Criança, em Almirante Tamandaré, Paraná, Brasil. O risco ao desmame foi considerado como variável resposta e os dados do questionário, variáveis preditoras. Os dados foram analisados através do método de Kaplan-Meier, modelo de regressão de Cox e correlação de Spearman (α = 0,05). Resultado: A tábua de vida atuarial revelou uma probabilidade condicional de desmame maior aos 12 meses de idade, seguido do primeiro e quarto meses. A análise multivariada mostrou que o contato com a mamadeira antes do sexto mês de vida [HR=17,16 (2,34-125,86)] e o contato com a chupeta antes do sexto mês de vida [HR=3,48 (1,90-6,38)] foram variáveis de risco associadas ao desmame. Entre as crianças desmamadas, por ocasião da entrevista, a duração da amamentação apresentou correlação positiva com a idade do primeiro contato com açúcar (r s =+0,419; p=0,001) e negativa com a duração do uso de chupeta (r s =-0,300; p=0,017). Conclusão: O uso da mamadeira e da chupeta estiveram relacionados a uma menor duração do aleitamento materno nestas comunidades. .

Síndrome metabólica em adolescentes de diferentes estados nutricionais / Metabolic syndrome in adolescents of different nutritional status

OBJETIVO: Verificar a prevalência de síndrome metabólica (SM) em adolescentes de diferentes estados nutricionais. SUJEITOS E MÉTODOS: A amostra constitui-se de 582 adolescentes de 12 a 18 anos de idade. A classificação do estado nutricional por meio do índice de massa corporal (IMC) foi realizada utilizando as tabelas de referência do NCHS. A SM foi diagnosticada se três ou mais fatores de risco estivessem presentes. RESULTADOS: A prevalência geral de SM foi 6,7% (IC: 4,9%-9%); rapazes 9,4%; moças 4,1%. Prevalência de SM de 17,2% (IC: 10%-28,2%) e 37,1% (IC: 23,2-53,7%) foi observada em adolescentes com sobrepeso e obesidade, respectivamente. Todos os adolescentes obesos tinham pelo menos um fator de risco presente e demonstraram elevada razão de prevalência de SM comparados aos adolescentes com peso normal (RP: 11,1; IC: 5,75-21,47). CONCLUSÃO: Alta prevalência de SM foi observada em adolescentes obesos, neste sentido, estratégias de prevenção devem ser concentradas no controle do peso corporal desde o início da adolescência.

OBJECTIVE: To investigate the prevalence of metabolic syndrome (MetS) in adolescents of different nutritional status. SUBJECTS AND METHODS: The sample consisted of 582 adolescents aged 12 to 18 years. Body mass index (BMI) classification of nutritional status was performed using the NCHS growth charts. MetS diagnosis was determined by the presence of three or more risk factors. RESULTS: Overall MetS prevalence was 6.7% (CI: 4.9%-9%); in boys, prevalence was 9.4%; and in girls, 4.1%. MetS prevalence was 17.2% (CI: 10%-28.2%) and 37.1% (CI: 23.2%-53.7%) in overweight and obese adolescents, respectively. All obese adolescents had at least one risk factor present, and demonstrated high MetS prevalence ratio compared with adolescents of normal weight (PR: 11.1; CI: 5.75-21.47). CONCLUSION: High prevalence of MetS was observed in obese adolescents. Prevention strategies should focus on body weight control since the beginning of adolescence.

Avaliação da função diastólica em crianças e adolescentes diabéticos tipo 1 - Existem sinais precoces de miocardiopatia diabética? / Assessment of diastolic function in children and adolescents with type 1 diabetes mellitus - Are there early signs of diabetic cardiomyopathy?

OBJETIVOS: Avaliar a função diastólica (FD) de crianças e adolescentes diabéticos tipo 1 (DM1). SUJEITOS E MÉTODOS: Estudo transversal de 67 DM1, sem comorbidades, e grupo controle (n = 84) da mesma faixa etária. Analisaram-se: idade, sexo, índice de massa corpórea (IMC), Dopplere-cocardiografia e eletrocardiograma de ambos os grupos e, nos portadores de DM1, o tempo de doença, HbA1C, lipidograma e o valor da microalbuminúria. RESULTADOS: Encontraram-se alterações diastólicas [(A e E mitral, relação E/A, tempo de relaxamento isovolumétrico (TRIV) e tempo de desaceleração da onda E (TDE)] nos diabéticos, com maior prevalência nas meninas na faixa 13-17 anos. TRIV e TDE correlacionaram-se positivamente com o IMC (p = 0,028). Idade e tempo de doença foram fatores preditivos para a onda A mitral (p = 0,004 e 0,033, respectivamente). CONCLUSÕES: Alterações de FD foram detectadas nos DM1, com maior prevalência em meninas púberes. Tempo de doença e idade dos pacientes influenciaram parâmetros de FD.

OBJECTIVES: To evaluate diastolic function (DF) of children and adolescents with type 1 diabetes mellitus (DM1). SUBJECTS AND METHODS: Cross-sectional study of 67 otherwise healthy diabetic patients, and a control group (n = 84) in regard to age, sex, body mass index (BMI), Dopplere-chocardiography, and ECG for both groups; and disease duration, HbA1C, microalbuminuria, and serum lipids for DM 1 patients. RESULTS: Diastolic alterations [(A and E mitral waves, E/A ratio, isovolumic relaxation time (IVRT) and E wave deceleration time (EWDT)] were found in diabetic patients, with higher prevalence among pubertal girls (13-17 years old). IVRT and EWDT correlated positively with BMI (p = 0.028). Chronological age and disease duration were predictive factors for mitral A wave (p = 0.004 and 0.033, respectively). CONCLUSIONS: DF alterations were detected in the group of diabetic patients, with greater prevalence among pubertal girls; disease duration and age influenced parameters of DF.