Detalhe da pesquisa
1.
Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea.
J Pharmacol Exp Ther
; 357(2): 423-31, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26907621
2.
Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region.
Bioorg Med Chem Lett
; 21(21): 6348-52, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21955943
3.
1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.
Bioorg Med Chem Lett
; 20(10): 3125-8, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20400309
4.
1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors.
Bioorg Med Chem Lett
; 20(10): 3120-4, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20443228
5.
Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril.
J Pharmacol Exp Ther
; 330(1): 191-7, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19349522
6.
Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.
Bioorg Med Chem Lett
; 19(17): 5209-13, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19631533
7.
Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
Bioorg Med Chem Lett
; 19(15): 4092-6, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19539468
8.
Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
Bioorg Med Chem Lett
; 19(15): 4088-91, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19540112
9.
Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure.
Circ Res
; 93(1): 69-76, 2003 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-12791709
10.
Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.
J Med Chem
; 53(18): 6653-80, 2010 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20726512
11.
Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).
J Med Chem
; 53(6): 2656-60, 2010 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20196613
12.
Role of PYK2 in the development of obesity and insulin resistance.
Biochem Biophys Res Commun
; 334(4): 1085-91, 2005 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-16039993