Detalhe da pesquisa
1.
A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multiorgan activity and shows translational relevance to humans.
Hepatology
; 78(3): 709-726, 2023 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36999529
2.
Dietary thylakoids reduce visceral fat mass and increase expression of genes involved in intestinal fatty acid oxidation in high-fat fed rats.
Am J Physiol Regul Integr Comp Physiol
; 311(3): R618-27, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27488889
3.
Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG.
Drug Metab Dispos
; 44(4): 527-33, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26851239
4.
Characterisation of artemisinin-chloroquinoline hybrids for potential metabolic liabilities.
Xenobiotica
; 46(3): 234-40, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26338168
5.
Mechanism-Based Insights into Removing the Mutagenicity of Aromatic Amines by Small Structural Alterations.
J Med Chem
; 64(12): 8545-8563, 2021 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34110134
6.
Exploration of catalytic properties of CYP2D6 and CYP3A4 through metabolic studies of levorphanol and levallorphan.
Drug Metab Dispos
; 38(1): 187-99, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19797609
7.
Enhanced metabolite identification with MS(E) and a semi-automated software for structural elucidation.
Rapid Commun Mass Spectrom
; 24(21): 3127-38, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20941759
8.
Pulmonary Metabolism of Substrates for Key Drug-Metabolizing Enzymes by Human Alveolar Type II Cells, Human and Rat Lung Microsomes, and the Isolated Perfused Rat Lung Model.
Pharmaceutics
; 12(2)2020 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32024122
9.
Dual Role For A MEK Inhibitor As A Modulator Of Inflammation And Host Defense Mechanisms With Potential Therapeutic Application In COPD.
Int J Chron Obstruct Pulmon Dis
; 14: 2611-2624, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-32063702
10.
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl}carbonyl)cyclopropanecarboxylic Acid (AZD9898) as a New Treatment for Asthma.
J Med Chem
; 62(17): 7769-7787, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31415176
11.
The molecular basis of CYP2D6-mediated N-dealkylation: balance between metabolic clearance routes and enzyme inhibition.
Drug Metab Dispos
; 36(11): 2199-210, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18725510
12.
Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration.
J Med Chem
; 60(12): 5057-5071, 2017 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28520415
13.
Montelukast Disposition: No Indication of Transporter-Mediated Uptake in OATP2B1 and OATP1B1 Expressing HEK293 Cells.
Pharmaceutics
; 7(4): 554-64, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26694455
14.
Physicochemical and drug metabolism characterization of a series of 4-aminoquinoline-3-hydroxypyridin-4-one hybrid molecules with antimalarial activity.
Expert Opin Drug Metab Toxicol
; 10(10): 1313-24, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25219629