Detalhe da pesquisa
1.
Promotion of a synthetic degradation of activated STAT6 by PARP-1 inhibition: roles of poly(ADP-ribosyl)ation, calpains and autophagy.
J Transl Med
; 20(1): 521, 2022 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36348405
2.
Microparticles in systemic sclerosis: Potential pro-inflammatory mediators and pulmonary hypertension biomarkers.
Respirology
; 24(7): 675-683, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30747487
3.
PARP-1 Is Critical for Recruitment of Dendritic Cells to the Lung in a Mouse Model of Asthma but Dispensable for Their Differentiation and Function.
Mediators Inflamm
; 2019: 1656484, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31178661
4.
Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway.
J Transl Med
; 16(1): 243, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30172259
5.
PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis.
J Hepatol
; 66(3): 589-600, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27984176
6.
Treatment with intranasal iloprost reduces disease manifestations in a murine model of previously established COPD.
Am J Physiol Lung Cell Mol Physiol
; 310(7): L630-8, 2016 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26851260
7.
Potential of Inducible Nitric Oxide Synthase as a Therapeutic Target for Allergen-Induced Airway Hyperresponsiveness: A Critical Connection to Nitric Oxide Levels and PARP Activity.
Mediators Inflamm
; 2016: 1984703, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27524861
8.
DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4⺠T-cell function without causing severe combined immunodeficiency.
J Allergy Clin Immunol
; 135(2): 425-40, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25441643
9.
Poly(ADP-ribose) polymerase as a novel regulator of 17ß-estradiol-induced cell growth through a control of the estrogen receptor/IGF-1 receptor/PDZK1 axis.
J Transl Med
; 13: 233, 2015 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26183824
10.
PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4(+) T cell function.
J Transl Med
; 13: 225, 2015 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26169874
11.
Poly (ADP-ribose) polymerase-1 is a key mediator of liver inflammation and fibrosis.
Hepatology
; 59(5): 1998-2009, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24089324
12.
PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice.
Clin Sci (Lond)
; 129(11): 951-62, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26205779
13.
Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated deoxyribonuclease and the poly(ADP-ribose) polymerase-regulated DNAS1L3, an endoplasmic reticulum-localized endonuclease that translocates to the nucleus during apoptosis.
J Biol Chem
; 288(5): 3460-8, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23229555
14.
Minocycline blocks asthma-associated inflammation in part by interfering with the T cell receptor-nuclear factor κB-GATA-3-IL-4 axis without a prominent effect on poly(ADP-ribose) polymerase.
J Biol Chem
; 288(3): 1458-68, 2013 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23184953
15.
Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37.
Mol Med
; 20: 270-9, 2014 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24869908
16.
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation.
Nat Cell Biol
; 9(10): 1175-83, 2007 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17891139
17.
Unconventional activation of PRKDC by TNF-α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex.
J Inflamm (Lond)
; 21(1): 14, 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38689261
18.
PDZK1 is a novel factor in breast cancer that is indirectly regulated by estrogen through IGF-1R and promotes estrogen-mediated growth.
Mol Med
; 19: 253-62, 2013 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23821363
19.
Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation.
J Immunol
; 185(5): 3076-85, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20668217
20.
Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation.
J Immunol
; 185(3): 1894-902, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20610652