Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

HLA-B27.

Bowness, Paul.

Annu Rev Immunol ; 33: 29-48, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-25861975

2.

Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.

Yang, Xinbo; Garner, Lee I; Zvyagin, Ivan V; Paley, Michael A; Komech, Ekaterina A; Jude, Kevin M; Zhao, Xiang; Fernandes, Ricardo A; Hassman, Lynn M; Paley, Grace L; Savvides, Christina S; Brackenridge, Simon; Quastel, Max N; Chudakov, Dmitriy M; Bowness, Paul; Yokoyama, Wayne M; McMichael, Andrew J; Gillespie, Geraldine M; Garcia, K Christopher.

Nature ; 612(7941): 771-777, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36477533

3.

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism.

Cribbs, Adam P; Terlecki-Zaniewicz, Stefan; Philpott, Martin; Baardman, Jeroen; Ahern, David; Lindow, Morten; Obad, Susanna; Oerum, Henrik; Sampey, Brante; Mander, Palwinder K; Penn, Henry; Wordsworth, Paul; Bowness, Paul; de Winther, Menno; Prinjha, Rab K; Feldmann, Marc; Oppermann, Udo.

Proc Natl Acad Sci U S A ; 117(11): 6056-6066, 2020 03 17.

Artigo em Inglês | MEDLINE | ID: mdl-32123118

4.

Identification of an Unconventional Subpeptidome Bound to the Behçet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1).

Chen, Liye; Shi, Hui; Koftori, Danai; Sekine, Takuya; Nicastri, Annalisa; Ternette, Nicola; Bowness, Paul.

Mol Cell Proteomics ; 19(5): 871-883, 2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-32161166

5.

Ex vivo mass cytometry analysis reveals a profound myeloid proinflammatory signature in psoriatic arthritis synovial fluid.

Yager, Nicole; Cole, Suzanne; Lledo Lara, Alicia; Maroof, Ash; Penkava, Frank; Knight, Julian C; Bowness, Paul; Al-Mossawi, Hussein.

Ann Rheum Dis ; 80(12): 1559-1567, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34226188

6.

Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation.

Lim Kam Sian, Terry C C; Indumathy, Saranjah; Halim, Hanim; Greule, Anja; Cryle, Max J; Bowness, Paul; Rossjohn, Jamie; Gras, Stephanie; Purcell, Anthony W; Schittenhelm, Ralf B.

J Biol Chem ; 294(52): 20185-20195, 2019 12 27.

Artigo em Inglês | MEDLINE | ID: mdl-31740583

7.

New developments in our understanding of ankylosing spondylitis pathogenesis.

Voruganti, Aniruddha; Bowness, Paul.

Immunology ; 161(2): 94-102, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32696457

8.

Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication.

Antoniou, Antony Nicodemus; Lenart, Izabela; Kriston-Vizi, Janos; Iwawaki, Takao; Turmaine, Mark; McHugh, Kirsty; Ali, Sadfer; Blake, Neil; Bowness, Paul; Bajaj-Elliott, Mona; Gould, Keith; Nesbeth, Darren; Powis, Simon J.

Ann Rheum Dis ; 78(1): 74-82, 2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30355574

9.

Progress in our understanding of the pathogenesis of ankylosing spondylitis.

Simone, Davide; Al Mossawi, M Hussein; Bowness, Paul.

Rheumatology (Oxford) ; 57(suppl_6): vi4-vi9, 2018 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-30445483

10.

CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.

Hammitzsch, Ariane; Tallant, Cynthia; Fedorov, Oleg; O'Mahony, Alison; Brennan, Paul E; Hay, Duncan A; Martinez, Fernando O; Al-Mossawi, M Hussein; de Wit, Jelle; Vecellio, Matteo; Wells, Christopher; Wordsworth, Paul; Müller, Susanne; Knapp, Stefan; Bowness, Paul.

Proc Natl Acad Sci U S A ; 112(34): 10768-73, 2015 Aug 25.

Artigo em Inglês | MEDLINE | ID: mdl-26261308

11.

Position 97 of HLA-B, a residue implicated in pathogenesis of ankylosing spondylitis, plays a key role in cell surface free heavy chain expression.

Chen, Liye; Shi, Hui; Yuan, Jack; Bowness, Paul.

Ann Rheum Dis ; 76(3): 593-601, 2017 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-27515058

12.

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.

Vecellio, Matteo; Roberts, Amity R; Cohen, Carla J; Cortes, Adrian; Knight, Julian C; Bowness, Paul; Wordsworth, B Paul.

Ann Rheum Dis ; 75(8): 1534-40, 2016 08.

Artigo em Inglês | MEDLINE | ID: mdl-26452539

13.

An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.

Roberts, Amity R; Vecellio, Matteo; Chen, Liye; Ridley, Anna; Cortes, Adrian; Knight, Julian C; Bowness, Paul; Cohen, Carla J; Wordsworth, B Paul.

Ann Rheum Dis ; 75(12): 2150-2156, 2016 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-26916345

14.

Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.

Chen, Liye; Ridley, Anna; Hammitzsch, Ariane; Al-Mossawi, Mohammad Hussein; Bunting, Helen; Georgiadis, Dimitris; Chan, Antoni; Kollnberger, Simon; Bowness, Paul.

Ann Rheum Dis ; 75(5): 916-23, 2016 May.

Artigo em Inglês | MEDLINE | ID: mdl-26130142

15.

Non-conventional forms of HLA-B27 are expressed in spondyloarthritis joints and gut tissue.

Rysnik, Oliwia; McHugh, Kirsty; van Duivenvoorde, Leonie; van Tok, Melissa; Guggino, Giuliana; Taurog, Joel; Kollnberger, Simon; Ciccia, Francesco; Baeten, Dominique; Bowness, Paul.

J Autoimmun ; 70: 12-21, 2016 06.

Artigo em Inglês | MEDLINE | ID: mdl-27036372

16.

KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis.

Wong-Baeza, Isabel; Ridley, Anna; Shaw, Jackie; Hatano, Hiroko; Rysnik, Oliwia; McHugh, Kirsty; Piper, Christopher; Brackenbridge, Simon; Fernandes, Ricardo; Chan, Anthoni; Bowness, Paul; Kollnberger, Simon.

J Immunol ; 190(7): 3216-24, 2013 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-23440420

17.

Evolution of CD8+ T cell responses after acute PARV4 infection.

Simmons, Ruth; Sharp, Colin; Levine, Jordana; Bowness, Paul; Simmonds, Peter; Cox, Andrea; Klenerman, Paul.

J Virol ; 87(6): 3087-96, 2013 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-23283958

18.

Expression of aberrant HLA-B27 molecules is dependent on B27 dosage and peptide supply.

McHugh, Kirsty; Rysnik, Oliwia; Kollnberger, Simon; Shaw, Jacqueline; Utriainen, Lotta; Al-Mossawi, Mohammad Hussein; Payeli, Sravan; Belaunzaran, Osiris Marroquin; Milling, Simon; Renner, Christoph; Bowness, Paul.

Ann Rheum Dis ; 73(4): 763-70, 2014 04.

Artigo em Inglês | MEDLINE | ID: mdl-23625978

19.

Rapid antigen processing and presentation of a protective and immunodominant HLA-B*27-restricted hepatitis C virus-specific CD8+ T-cell epitope.

Schmidt, Julia; Iversen, Astrid K N; Tenzer, Stefan; Gostick, Emma; Price, David A; Lohmann, Volker; Distler, Ute; Bowness, Paul; Schild, Hansjörg; Blum, Hubert E; Klenerman, Paul; Neumann-Haefelin, Christoph; Thimme, Robert.

PLoS Pathog ; 8(11): e1003042, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-23209413

20.

HLA-B27 homodimers and free H chains are stronger ligands for leukocyte Ig-like receptor B2 than classical HLA class I.

Giles, Joanna; Shaw, Jackie; Piper, Christopher; Wong-Baeza, Isabel; McHugh, Kirsty; Ridley, Anna; Li, Demin; Lenart, Izabela; Antoniou, Antony N; DiGleria, Katilin; Kuroki, Kimiko; Maenaka, Katsumi; Bowness, Paul; Kollnberger, Simon.

J Immunol ; 188(12): 6184-93, 2012 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-22593621

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