Clinical value of FDG-PET/CT in bacteremia of unknown origin with catalase-negative gram-positive cocci or Staphylococcus aureus.

INTRODUCTION: Bacteremia is associated with high mortality, especially when the site of infection is unknown. While conventional imaging usually focus on specific body parts, FDG-PET/CT visualizes hypermetabolic foci throughout the body. PURPOSE: To investigate the ability of FDG/PET-CT to detect the site of infection and its clinical impact in bacteremia of unknown origin with catalase-negative Gram-positive cocci (excluding pneumococci and enterococci) or Staphylococcus aureus (BUOCSA). METHODS: We retrospectively identified 157 patients with 165 episodes of BUOCSA, who subsequently underwent FDG-PET/CT. Data were collected from medical records. Decision regarding important sites of infection in patients with bacteremia was based on the entire patient course and served as reference diagnosis for comparison with FDG-PET/CT findings. FDG-PET/CT was considered to have high clinical impact if it correctly revealed site(s) of infection in areas not assessed by other imaging modalities or if other imaging modalities were negative/equivocal in these areas, or if it established a new clinically relevant diagnosis, and/or led to change in antimicrobial treatment. RESULTS: FDG-PET/CT detected sites of infection in 56.4% of cases and had high clinical impact in 47.3%. It was the first imaging modality to identify sites of infection in 41.1% bacteremia cases, led to change of antimicrobial therapy in 14.7%, and established a new diagnosis unrelated to bacteremia in 9.8%. Detection rate and clinical impact were not significantly influenced by duration of antimicrobial treatment preceding FDG-PET/CT, days from suspicion of bacteremia to FDG-PET/CT-scan, type of bacteremia, or cancer. CONCLUSION: FDG-PET/CT appears clinically useful in BUOCSA. Prospective studies are warranted for confirmation.

Prevalence of users of medication targeting obstructive lung disease, the reasons for prescriptions and the use of spirometry in Upernavik Health Center in the period from 2011-2016, a retrospective observational study as basis for future quality development.

Chronic obstructive pulmonary disease (COPD) is a health problem globally. Smoking is a risk factor. In Greenland over 50% are smokers. Upernavik Healthcare Center serves the town of Upernavik and its 9 remote settlements. Many patients were treated with medications targeting obstructive pulmonary disease (ATC code R03). This retrospective observational study estimated the prevalence of users of R03 medication aged 50 years or above, investigated if spirometry was performed, the reason for prescription and smoking status. The study is based on review of data from the electronic medical journal. Permanent residents with prescriptions of R03 medication within a period of 5 years were included. Reasons for prescription and smoking status was registrated. The prevalence of users of R03 medications was 7,6%. 37,8% had a spirometry performed. The reason for prescribing varied from no reason to COPD-like. R03 medications were prescribed years before spirometry. 37,8% of the patients were smokers. Prevalence of users was comparable to other studies in Greenland. There was lack of spirometry and a discrepancy to guidelines. Patients had prescriptions of R03 medication years without a specific diagnosis. This warrant a new strategy for identification, increase of spirometry and treatment of patients with COPD to be developed.