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1.
J Wound Care ; 33(5): 312-323, 2024 May 02.
Artigo em Inglês | MEDLINE | ID: mdl-38683778

RESUMO

OBJECTIVE: Using a dressing that expands and conforms to the wound bed upon exudate absorption is one of the best ways to promote wound healing. While many products claim wound bed conformability, no externally replicated or verified test methodology had been developed to quantify a wound dressing's ability to conform to the wound bed. The Relative Swelling Rise (RSR) test methodology was developed to measure the relative swelling rise of foam dressings upon fluid absorption, and offers a quantifiable and easily replicated method to measure wound bed conformability. METHOD: The RSR test method was developed, validated and reliability tested by Coloplast A/S, Denmark. External replication was provided by ALS Odense, Denmark (previously DB Lab). Circular fences provide a fixed diameter to apply and contain the fluid and prevent horizontal spreading in the test set-up. The swelling height is quantified relative to the fence's inner diameter, i.e., the ratio alpha (α), and allows evaluation of a material's ability to conform to the wound bed. RESULTS: Biatain Silicone foam products (n=3, Coloplast A/S, Denmark) were tested, all afforded an average α-ratio from 0.30 to 0.60. The relative standard deviations were between 1-3%, demonstrating the strength of the test. Robustness of the methodology was demonstrated through the internal validation study, the reliability study, and both an internal and external replication study, as well as a systematic literature review and expert review of the construct, content, criterion and generalisability of the method. CONCLUSION: Having a validated, effective and easily replicable testing method to quantify wound bed conformability of foam dressings is an important step towards achieving better healing outcomes.


Assuntos
Bandagens , Cicatrização , Humanos , Reprodutibilidade dos Testes , Exsudatos e Transudatos , Teste de Materiais , Ferimentos e Lesões/terapia
2.
Adv Skin Wound Care ; 32(3): 109-121, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30801349

RESUMO

GENERAL PURPOSE: To synthesize the literature regarding skin injuries that are found in patients at the end of life and to clarify the terms used to describe these conditions. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After completing this continuing education activity, you should be better able to:1. Define the terms used to describe pressure injuries and skin changes at the end of life.2. Discuss the concept of skin failure as applied to end-of-life skin injuries and implications for practice. ABSTRACT: This article synthesizes the literature regarding the concepts of "terminal" skin injuries that are found in patients at the end of life, including Kennedy terminal ulcers, Skin Changes At Life's End, Trombley-Brennan terminal tissue injuries, and skin failure. Also included is a discussion of avoidable and unavoidable pressure injuries as defined and differentiated by the Centers for Medicare & Medicaid Services and the National Pressure Ulcer Advisory Panel. To help clarify the controversy among these terms, a unifying concept of "skin failure" that may occur with an acute illness, chronic illness, or as part of the dying process is proposed. This proposed concept of skin failure is etiologically different than a pressure injury, although pressure injury and skin failure can occur concomitantly. These proposed concepts require further research and validated diagnostic criteria. Consensus around appropriate terminology is essential to reduce confusion among stakeholders and ensure appropriate patient care.


Assuntos
Assistência de Longa Duração/normas , Úlcera por Pressão/diagnóstico , Úlcera por Pressão/enfermagem , Assistência Terminal/organização & administração , Humanos , Papel do Profissional de Enfermagem , Planejamento de Assistência ao Paciente/organização & administração , Lesões dos Tecidos Moles/diagnóstico , Lesões dos Tecidos Moles/enfermagem , Úlcera , Cicatrização
4.
J Wound Ostomy Continence Nurs ; 44(2): 172-180, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28267125

RESUMO

PURPOSE: The purpose of this study was to evaluate the efficacy of an investigational skin protectant product at managing severe skin breakdown associated with incontinence. DESIGN: Open-label, nonrandomized, prospective study. SUBJECTS AND SETTING: The sample comprised 16 patients; inclusion criteria were: patients older than 18 years, cared for in the intensive care unit of a level I trauma center hospital or in long-term care facilities in the northeast region of the United States, and had incontinence-associated dermatitis (IAD). Twelve of the patients had epidermal skin loss and 4 had severe redness. METHODS: The investigational product is a formulation based on acrylate chemistry. The skin protectant application schedule was twice weekly for up to 3 weeks for a maximum of 6 applications during the study period. The skin was evaluated via a skin assessment instrument specifically designed for use in this study; this instrument has not undergone validation studies. The main outcome measure was changes in the instrument score over time. In addition, complete reepithelialization was recorded when observed, and pain scores (associated with IAD) were noted in participants who were able to report pain. RESULTS: The IAD score improved in 13 of 16 patients, remained unchanged in 1 patient, and deteriorated in 2 patients. The median percent improvement in the skin assessment instrument was 96% (P = .013). Four of the patients with epidermal skin loss had complete reepithelialization of the skin surface with 4 to 6 applications of the skin protectant, and 5 had substantial improvement. The 4 patients with severe red skin returned to healthy normal skin with 2 to 4 skin protectant applications. Substantial pain reduction was reported by all 9 patients who reported pain at enrollment. No adverse events associated with the skin protectant application were reported during data collection. CONCLUSION: Results of this study suggest that an acrylate-based product, evaluated here for the first time in patients, may be effective as a protective barrier in the presence of continued incontinence. Additional research is needed to confirm these findings.


Assuntos
Dermatite/terapia , Incontinência Fecal/enfermagem , Avaliação de Resultados da Assistência ao Paciente , Incontinência Urinária/enfermagem , Acrilatos/farmacologia , Acrilatos/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos
6.
J Wound Ostomy Continence Nurs ; 43(5): 455-63, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27509367

RESUMO

This article reports the findings of the Unavoidable Pressure Ulcer Committee (of the VCU Pressure Ulcer Summit) that was tasked with addressing key issues associated with pressure injuries that are unavoidable or unpreventable. Our goals were (1) to clarify nomenclature and descriptions surrounding "terminal ulceration," (2) to describe the medical complications and comorbid conditions that can lead to skin failure and/or terminal ulceration, (3) to describe the variable possible causes of unavoidable pressure injuries, and (4) to present clinical cases to exemplify pressure injuries considered to be unavoidable.


Assuntos
Úlcera por Pressão/classificação , Índice de Gravidade de Doença , Pele/lesões , Humanos , Insuficiência de Múltiplos Órgãos/complicações , Úlcera por Pressão/etiologia , Medição de Risco/métodos , Assistência Terminal
7.
J Nurs Care Qual ; 29(2): 182-7, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24002220

RESUMO

Prevention of pressure ulcers is an ongoing concern. This article reports on the evaluation and usage of a new positioning device that adapts to the contours of the body and led to a decrease in the incidence of nosocomial pressure ulcers in a cardiothoracic intensive care unit.


Assuntos
Posicionamento do Paciente/instrumentação , Úlcera por Pressão/enfermagem , Úlcera por Pressão/prevenção & controle , Melhoria de Qualidade , Desenho de Equipamento , Feminino , Humanos , Capacitação em Serviço , Unidades de Terapia Intensiva , Masculino
9.
Am J Hosp Palliat Care ; 36(11): 1016-1019, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30991821

RESUMO

In 2012, we published a study in this journal exploring the emergence of unique skin changes in end-of-life patients admitted to a palliative care unit. The purpose of the study was to describe the skin changes and identify the relationship between these changes and time of death. In the above study of 80 patients, the skin changes were found to be unique and different from Kennedy terminal ulcers and deep tissue injuries. Median time from identification of skin changes and death was 36 hours. The phenomenon was named as Trombley-Brennan terminal tissue injury. The current article presents findings that include the study of additional 86 patients. The results further validate the phenomenon and its relationship with time of death.


Assuntos
Enfermagem de Cuidados Paliativos na Terminalidade da Vida/economia , Medicaid/economia , Medicare/economia , Úlcera por Pressão/economia , Úlcera por Pressão/mortalidade , Úlcera por Pressão/enfermagem , Assistência Terminal/economia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Enfermagem de Cuidados Paliativos na Terminalidade da Vida/estatística & dados numéricos , Humanos , Masculino , Medicaid/estatística & dados numéricos , Medicare/estatística & dados numéricos , Pessoa de Meia-Idade , Estudos Retrospectivos , Assistência Terminal/estatística & dados numéricos , Fatores de Tempo , Estados Unidos
11.
Am J Hosp Palliat Care ; 29(7): 541-5, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22218917

RESUMO

A group of palliative care nurses wanted to investigate the phenomenon they were witnessing in their end-of-life patients. There was a rapid onset of skin change characterized by bruising on various parts of the body in these patients. Traditionally they were described as pressure ulcers. However, the skin changes did not progress as typical pressure ulcers and warranted more investigation.


Assuntos
Dermatopatias/epidemiologia , Assistência Terminal , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Úlcera por Pressão/epidemiologia , Úlcera por Pressão/fisiopatologia , Estudos Retrospectivos , Dermatopatias/fisiopatologia , Fatores de Tempo
12.
J Nat Prod ; 71(3): 453-6, 2008 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18197605

RESUMO

A new proline-rich cyclodecapeptide, designated stylopeptide 2, has been isolated from a cytotoxic extract of the Papua New Guinea marine sponge Stylotella sp. and found to correspond to structure 1. The structural assignment was based on HRMS collision-induced dissociation tandem mass spectrometry (CID MS/MS), NMR spectroscopic data, and amino acid analysis, which led to assignment of the absolute configuration.


Assuntos
Peptídeos Cíclicos/química , Peptídeos Cíclicos/isolamento & purificação , Poríferos/química , Animais , Estrutura Molecular , Papua Nova Guiné , Prolina/química
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