Detalhe da pesquisa
1.
Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3'-(substituted phenyl)deschloroepibatidine analogs.
Bioorg Med Chem
; 16(2): 746-54, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17964169
2.
Synthesis, monoamine transporter binding, properties, and functional monoamine uptake activity of 3beta-[4-methylphenyl and 4-chlorophenyl]-2 beta-[5-(substituted phenyl)thiazol-2-yl]tropanes.
J Med Chem
; 50(15): 3686-95, 2007 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17602602
3.
Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine.
J Med Chem
; 50(25): 6383-91, 2007 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-17994682
4.
Synthesis and pharmacological characterization of exo-2-(2'-chloro-5-pyridinyl)-7-(endo and exo)-aminobicyclo[2.2.1]heptanes as novel epibatidine analogues.
J Med Chem
; 48(23): 7491-5, 2005 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-16279810
5.
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-substituted deschloroepibatidine analogues. Novel nicotinic antagonists.
J Med Chem
; 48(4): 1221-8, 2005 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15715488
6.
Combining Active Immunization with Monoclonal Antibody Therapy To Facilitate Early Initiation of a Long-Acting Anti-Methamphetamine Antibody Response.
J Med Chem
; 58(11): 4665-77, 2015 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25973614
7.
Novel Synthesis and Pharmacological Characterization of NOP Receptor Agonist 8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198).
ACS Chem Neurosci
; 6(12): 1956-64, 2015 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26367173
8.
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted phenyl)deschloroepibatidine analogues. Novel nicotinic antagonist.
J Med Chem
; 47(18): 4588-94, 2004 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-15317468
9.
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2',3'-disubstituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes: epibatidine analogues.
J Med Chem
; 45(21): 4755-61, 2002 Oct 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12361403
10.
Design, synthesis, and biological evaluation of (3R)-1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) analogues: in vitro pharmacology and ADME profile.
J Med Chem
; 57(17): 7367-81, 2014 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25133923
11.
Effect of the 3- and 4-methyl groups on the opioid receptor properties of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines.
J Med Chem
; 57(7): 3140-7, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24635568
12.
Discovery of N-{4-[(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl-2-methylpropyl}-4-phenoxybenzamide analogues as selective kappa opioid receptor antagonists.
J Med Chem
; 56(11): 4551-67, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23651437
13.
Analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in vitro and in vivo opioid receptor antagonist activity.
J Med Chem
; 53(14): 5290-301, 2010 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20568781