Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Pharmacokinetic/Pharmacodynamic Correlation Analysis of Amantadine for Levodopa-Induced Dyskinesia.

Brigham, Elizabeth F; Johnston, Tom H; Brown, Carl; Holt, Jonathon D S; Fox, Susan H; Hill, Michael P; Howson, Patrick A; Brotchie, Jonathan M; Nguyen, Jack T.

J Pharmacol Exp Ther ; 367(2): 373-381, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30087157

2.

Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome.

Giacomini, Andrea; Stagni, Fiorenza; Trazzi, Stefania; Guidi, Sandra; Emili, Marco; Brigham, Elizabeth; Ciani, Elisabetta; Bartesaghi, Renata.

Neurobiol Dis ; 82: 385-396, 2015 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-26254735

3.

The ß-secretase-derived C-terminal fragment of ßAPP, C99, but not Aß, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.

Lauritzen, Inger; Pardossi-Piquard, Raphaëlle; Bauer, Charlotte; Brigham, Elizabeth; Abraham, Jean-Daniel; Ranaldi, Sébastien; Fraser, Paul; St-George-Hyslop, Peter; Le Thuc, Ophelia; Espin, Vanessa; Chami, Linda; Dunys, Julie; Checler, Frédéric.

J Neurosci ; 32(46): 16243-1655a, 2012 Nov 14.

Artigo em Inglês | MEDLINE | ID: mdl-23152608

4.

Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.

Garofalo, Albert W; Adler, Marc; Aubele, Danielle L; Brigham, Elizabeth F; Chian, David; Franzini, Maurizio; Goldbach, Erich; Kwong, Grace T; Motter, Ruth; Probst, Gary D; Quinn, Kevin P; Ruslim, Lany; Sham, Hing L; Tam, Danny; Tanaka, Pearl; Truong, Anh P; Ye, Xiaocong M; Ren, Zhao.

Bioorg Med Chem Lett ; 23(7): 1974-7, 2013 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-23453068

5.

Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious Î³-secretase inhibitors.

Ye, Xiaocong M; Konradi, Andrei W; Sun, Minghua; Yuan, Shendong; Aubele, Danielle L; Dappen, Michael; Dressen, Darren; Garofalo, Albert W; Jagodzinski, Jacek J; Latimer, Lee; Probst, Gary D; Sham, Hing L; Wone, David; Xu, Ying-zi; Ness, Daniel; Brigham, Elizabeth; Kwong, Grace T; Willtis, Chris; Tonn, George; Goldbach, Erich; Quinn, Kevin P; Zhang, Hongbin H; Sauer, John-Michael; Bova, Michael; Basi, Guriqbal S.

Bioorg Med Chem Lett ; 23(4): 996-1000, 2013 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-23312944

6.

School Nurses on the Front Lines of Healthcare: Emergencies Associated With Sport and Physical Activities (Part 4)-The Assessment of Pediatric Shoulder and Hip Injuries Utilizing the "SPASMS" Mnemonic.

Brigham, Elizabeth; Olympia, Robert P.

NASN Sch Nurse ; 37(6): 318-323, 2022 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-35722957

7.

Amino-caprolactam Î³-secretase inhibitors showing potential for the treatment of Alzheimer's disease.

Neitzel, Martin L; Aubele, Danielle L; Marugg, Jennifer L; Jagodzinski, Jacek J; Konradi, Andrei W; Pleiss, Michael A; Szoke, Balazs; Zmolek, Wes; Goldbach, Erich; Quinn, Kevin P; Sauer, John-Michael; Brigham, Elizabeth F; Wallace, William; Bova, Michael P; Hemphill, Susanna; Basi, Guriqbal.

Bioorg Med Chem Lett ; 21(12): 3715-20, 2011 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-21571529

8.

Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.

Bowers, Simeon; Truong, Anh P; Neitz, R Jeffrey; Neitzel, Martin; Probst, Gary D; Hom, Roy K; Peterson, Brian; Galemmo, Robert A; Konradi, Andrei W; Sham, Hing L; Tóth, Gergley; Pan, Hu; Yao, Nanhua; Artis, Dean R; Brigham, Elizabeth F; Quinn, Kevin P; Sauer, John-Michael; Powell, Kyle; Ruslim, Lany; Ren, Zhao; Bard, Frédérique; Yednock, Ted A; Griswold-Prenner, Irene.

Bioorg Med Chem Lett ; 21(6): 1838-43, 2011 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-21316234

9.

Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent Î³-secretase inhibitors.

Aubele, Danielle L; Truong, Anh P; Dressen, Darren B; Probst, Gary D; Bowers, Simeon; Mattson, Matthew N; Semko, Chris M; Sun, Minghua; Garofalo, Albert W; Konradi, Andrei W; Sham, Hing L; Zmolek, Wes; Wong, Karina; Goldbach, Erich; Quinn, Kevin P; Sauer, John-Michael; Brigham, Elizabeth F; Wallace, William; Nguyen, Lan; Bova, Michael P; Hemphill, Susanna S; Basi, Guriqbal.

Bioorg Med Chem Lett ; 21(19): 5791-4, 2011 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-21885276

10.

Discovery of sulfonamide-pyrazole gamma-secretase inhibitors.

Mattson, Matthew N; Neitzel, Martin L; Quincy, David A; Semko, Christopher M; Garofalo, Albert W; Keim, Pamela S; Konradi, Andrei W; Pleiss, Michael A; Sham, Hing L; Brigham, Elizabeth F; Goldbach, Erich G; Zhang, Hongbin; Sauer, John-Michael; Basi, Guriqbal S.

Bioorg Med Chem Lett ; 20(7): 2148-50, 2010 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-20206516

11.

Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.

Ye, Xiaocong M; Konradi, Andrei W; Smith, Jenifer; Xu, Ying-Zi; Dressen, Darren; Garofalo, Albert W; Marugg, Jennifer; Sham, Hing L; Truong, Anh P; Jagodzinski, Jacek; Pleiss, Michael; Zhang, Hongbin; Goldbach, Erich; Sauer, John-Michael; Brigham, Elizabeth; Bova, Michael; Basi, Guriqbal S.

Bioorg Med Chem Lett ; 20(7): 2195-9, 2010 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-20207136

12.

Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors (Part II).

Ye, Xiaocong M; Konradi, Andrei W; Smith, Jenifer; Aubele, Danielle L; Garofalo, Albert W; Marugg, Jennifer; Neitzel, Marty L; Semko, Chris M; Sham, Hing L; Sun, Minghua; Truong, Anh P; Wu, Jing; Zhang, Hongbin; Goldbach, Erich; Sauer, John-Michael; Brigham, Elizabeth F; Bova, Michael; Basi, Guriqbal S.

Bioorg Med Chem Lett ; 20(12): 3502-6, 2010 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-20529683

13.

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.

Truong, Anh P; Tóth, Gergley; Probst, Gary D; Sealy, Jennifer M; Bowers, Simeon; Wone, David W G; Dressen, Darren; Hom, Roy K; Konradi, Andrei W; Sham, Hing L; Wu, Jing; Peterson, Brian T; Ruslim, Lany; Bova, Michael P; Kholodenko, Dora; Motter, Ruth N; Bard, Frédérique; Santiago, Pamela; Ni, Huifang; Chian, David; Soriano, Ferdie; Cole, Tracy; Brigham, Elizabeth F; Wong, Karina; Zmolek, Wes; Goldbach, Erich; Samant, Bhushan; Chen, Linda; Zhang, Hongbing; Nakamura, David F; Quinn, Kevin P; Yednock, Ted A; Sauer, John-Michael.

Bioorg Med Chem Lett ; 20(21): 6231-6, 2010 Nov 01.

Artigo em Inglês | MEDLINE | ID: mdl-20833041

14.

Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.

Truong, Anh P; Aubele, Danielle L; Probst, Gary D; Neitzel, Martin L; Semko, Chris M; Bowers, Simeon; Dressen, Darren; Hom, Roy K; Konradi, Andrei W; Sham, Hing L; Garofalo, Albert W; Keim, Pamela S; Wu, Jing; Dappen, Michael S; Wong, Karina; Goldbach, Erich; Quinn, Kevin P; Sauer, John-Michael; Brigham, Elizabeth F; Wallace, William; Nguyen, Lan; Hemphill, Susanna S; Bova, Michael P; Bard, Frédérique; Yednock, Ted A; Basi, Guriqbal.

Bioorg Med Chem Lett ; 19(17): 4920-3, 2009 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-19660943

15.

School Nurses on the Front Lines of Medicine: Emergencies Associated With Sport and Physical Activities: Part 1.

Brigham, Elizabeth; Brady, Jodi; Olympia, Robert P.

NASN Sch Nurse ; 34(3): 155-161, 2019 May.

Artigo em Inglês | MEDLINE | ID: mdl-30741088

16.

Motivations for Compliance With Bracing in Adolescent Idiopathic Scoliosis.

Brigham, Elizabeth M; Armstrong, Douglas G.

Spine Deform ; 5(1): 46-51, 2017 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-28038693

17.

The Ignorance of Youth.

Brigham, Elizabeth M.

Fam Med ; 53(1): 67-68, 2021 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-33471927

18.

Like Father, Like Son: Cleidocranial Dysplasia: A Case Report.

Brigham, Elizabeth M; Hennrikus, William L.

JBJS Case Connect ; 5(4): e94, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-29252800

19.

Clinical Reasoning: An adolescent girl presenting with worsening vertigo, headache, and ataxia.

Brigham, Elizabeth; Sun, Chichun; Bronnenkant, Richard; Kumar, Ashutosh; Disori, Kristin.

Neurology ; 95(12): e1760-e1763, 2020 09 22.

Artigo em Inglês | MEDLINE | ID: mdl-32641534

20.

Freedom to Fly.

Brigham, Elizabeth.

J Grad Med Educ ; 11(2): 235-236, 2019 04.

Artigo em Inglês | MEDLINE | ID: mdl-31024661

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