Detalhe da pesquisa
1.
Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors.
J Biol Chem
; 298(10): 102375, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35970392
2.
Discovery of novel direct small-molecule inhibitors targeting HIF-2α using structure-based virtual screening, molecular dynamics simulation, and MM-GBSA calculations.
Mol Divers
; 2023 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37120484
3.
Design, synthesis, and biological investigation of oxadiazolyl, thiadiazolyl, and pyrimidinyl linked antipyrine derivatives as potential non-acidic anti-inflammatory agents.
J Enzyme Inhib Med Chem
; 38(1): 2162511, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36633257
4.
Targeting Opioid Receptors in Addiction and Drug Withdrawal: Where Are We Going?
Int J Mol Sci
; 24(13)2023 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37446064
5.
Disruption of Irisin Dimerization by FDA-Approved Drugs: A Computational Repurposing Approach for the Potential Treatment of Lipodystrophy Syndromes.
Int J Mol Sci
; 24(8)2023 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37108741
6.
Identification of Sesamin from Sesamum indicum as a Potent Antifungal Agent Using an Integrated in Silico and Biological Screening Platform.
Molecules
; 28(12)2023 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37375219
7.
Development of Quinazolinone Derivatives as Modulators of Virulence Factors of Pseudomonas aeruginosa Cystic Fibrosis Strains.
Molecules
; 28(18)2023 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37764311
8.
Pro-Apoptotic Activity of the Marine Sponge Dactylospongia elegans Metabolites Pelorol and 5-epi-Ilimaquinone on Human 501Mel Melanoma Cells.
Mar Drugs
; 20(7)2022 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35877720
9.
Resveratrol-like Compounds as SIRT1 Activators.
Int J Mol Sci
; 23(23)2022 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36499460
10.
Covalent Reversible Inhibitors of Cysteine Proteases Containing the Nitrile Warhead: Recent Advancement in the Field of Viral and Parasitic Diseases.
Molecules
; 27(8)2022 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35458759
11.
Role of hydrogen sulfide in cardiovascular ageing.
Pharmacol Res
; 160: 105125, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32783975
12.
Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors.
Molecules
; 25(8)2020 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32331470
13.
Cinnamides Target Leishmania amazonensis Arginase Selectively.
Molecules
; 25(22)2020 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33198198
14.
Synthesis, biological evaluation and molecular modeling of novel selective COX-2 inhibitors: sulfide, sulfoxide, and sulfone derivatives of 1,5-diarylpyrrol-3-substituted scaffold.
Bioorg Med Chem
; 27(19): 115045, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31427145
15.
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II).
Bioorg Chem
; 89: 103020, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31185392
16.
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome.
Exp Cell Res
; 368(2): 225-235, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29730163
17.
Computational Approaches for Drug Discovery.
Molecules
; 24(17)2019 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31443558
18.
A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles.
Molecules
; 24(23)2019 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31795400
19.
Verbascoside Inhibits Promastigote Growth and Arginase Activity of Leishmania amazonensis.
J Nat Prod
; 79(5): 1459-63, 2016 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27096224
20.
Targeting clinically-relevant metallo-ß-lactamases: from high-throughput docking to broad-spectrum inhibitors.
J Enzyme Inhib Med Chem
; 31(sup1): 98-109, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27121013