Detalhe da pesquisa
1.
Identification of small molecules and related targets that modulate tau pathology in a seeded primary neuron model.
J Biol Chem
; 299(7): 104876, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37269953
2.
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons.
Acta Neuropathol
; 147(1): 55, 2024 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38472475
3.
A small-molecule microtubule-stabilizing agent safely reduces Aß plaque and tau pathology in transgenic mouse models of Alzheimer's disease.
Alzheimers Dement
; 2024 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38884283
4.
Abundant copathologies of polyglucosan bodies, frontotemporal lobar degeneration with TDP-43 inclusions and ageing-related tau astrogliopathy in a family with a GBE1 mutation.
Neuropathol Appl Neurobiol
; 49(1): e12865, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36456471
5.
Preclinical characterization and IND-enabling safety studies for PNT001, an antibody that recognizes cis-pT231 tau.
Alzheimers Dement
; 19(10): 4662-4674, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37002928
6.
Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease.
Acta Neuropathol
; 143(1): 15-31, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34854996
7.
Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.
J Biol Chem
; 295(12): 4001-4013, 2020 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32034092
8.
In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics.
Acta Neuropathol
; 141(2): 193-215, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33385254
9.
Characterization of tau binding by gosuranemab.
Neurobiol Dis
; 146: 105120, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32991997
10.
Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease.
Neurobiol Dis
; 136: 104712, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31837422
11.
Correction of microtubule defects within Aß plaque-associated dystrophic axons results in lowered Aß release and plaque deposition.
Alzheimers Dement
; 16(10): 1345-1357, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32918367
12.
Design, synthesis and evaluation of photoactivatable derivatives of microtubule (MT)-active [1,2,4]triazolo[1,5-a]pyrimidines.
Bioorg Med Chem Lett
; 28(12): 2180-2183, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29764743
13.
The Dynamics and Turnover of Tau Aggregates in Cultured Cells: INSIGHTS INTO THERAPIES FOR TAUOPATHIES.
J Biol Chem
; 291(25): 13175-93, 2016 Jun 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27129267
14.
Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs.
Neurobiol Dis
; 105: 328-335, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28012891
15.
Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related Tauopathies.
J Pharmacol Exp Ther
; 357(2): 432-50, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26980057
16.
Therapeutic strategies for the treatment of tauopathies: Hopes and challenges.
Alzheimers Dement
; 12(10): 1051-1065, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27751442
17.
Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice.
Neurobiol Dis
; 73: 83-95, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25220759
18.
Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine.
Bioorg Med Chem Lett
; 25(21): 4980-4982, 2015 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25819095
19.
Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy.
J Biol Chem
; 288(21): 15194-210, 2013 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23532841
20.
Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation.
J Biol Chem
; 288(16): 11024-37, 2013 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23443659