Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

An IL-1ß-driven neutrophil-stromal cell axis fosters a BAFF-rich protumor microenvironment in individuals with multiple myeloma.

de Jong, Madelon M E; Fokkema, Cathelijne; Papazian, Natalie; Czeti, Ágnes; Appelman, Marjolein K; Vermeulen, Michael; van Heusden, Teddie; Hoogenboezem, Remco M; van Beek, Gregory; Tahri, Sabrin; Sanders, Mathijs A; van de Woestijne, Pieter C; Gay, Francesca; Moreau, Philippe; Büttner-Herold, Maike; Bruns, Heiko; van Duin, Mark; Broijl, Annemiek; Sonneveld, Pieter; Cupedo, Tom.

Nat Immunol ; 25(5): 820-833, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38600356

2.

ß₂-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression.

Hofbauer, Daniel; Mougiakakos, Dimitrios; Broggini, Luca; Zaiss, Mario; Büttner-Herold, Maike; Bach, Christian; Spriewald, Bernd; Neumann, Frank; Bisht, Savita; Nolting, Jens; Zeiser, Robert; Hamarsheh, Shaima'a; Eberhardt, Martin; Vera, Julio; Visentin, Cristina; De Luca, Chiara Maria Giulia; Moda, Fabio; Haskamp, Stefan; Flamann, Cindy; Böttcher, Martin; Bitterer, Katrin; Völkl, Simon; Mackensen, Andreas; Ricagno, Stefano; Bruns, Heiko.

Immunity ; 54(8): 1772-1787.e9, 2021 08 10.

Artigo em Inglês | MEDLINE | ID: mdl-34289378

3.

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.

Friscic, Jasna; Böttcher, Martin; Reinwald, Christiane; Bruns, Heiko; Wirth, Benjamin; Popp, Samantha-Josefine; Walker, Kellie Irene; Ackermann, Jochen A; Chen, Xi; Turner, Jason; Zhu, Honglin; Seyler, Lisa; Euler, Maximilien; Kirchner, Philipp; Krüger, René; Ekici, Arif B; Major, Triin; Aust, Oliver; Weidner, Daniela; Fischer, Anita; Andes, Fabian T; Stanojevic, Zeljka; Trajkovic, Vladimir; Herrmann, Martin; Korb-Pap, Adelheid; Wank, Isabel; Hess, Andreas; Winter, Johnathan; Wixler, Viktor; Distler, Jörg; Steiner, Günter; Kiener, Hans P; Frey, Benjamin; Kling, Lasse; Raza, Karim; Frey, Silke; Kleyer, Arnd; Bäuerle, Tobias; Hughes, Timothy R; Grüneboom, Anika; Steffen, Ulrike; Krönke, Gerhard; Croft, Adam P; Filer, Andrew; Köhl, Jörg; Klein, Kerstin; Buckley, Christopher D; Schett, Georg; Mougiakakos, Dimitrios; Hoffmann, Markus H.

Immunity ; 54(5): 1002-1021.e10, 2021 05 11.

Artigo em Inglês | MEDLINE | ID: mdl-33761330

4.

Reconstitution of EBV-directed T cell immunity by adoptive transfer of peptide-stimulated T cells in a patient after allogeneic stem cell transplantation for AITL.

Lammoglia Cobo, María Fernanda; Ritter, Julia; Gary, Regina; Seitz, Volkhard; Mautner, Josef; Aigner, Michael; Völkl, Simon; Schaffer, Stefanie; Moi, Stephanie; Seegebarth, Anke; Bruns, Heiko; Rösler, Wolf; Amann, Kerstin; Büttner-Herold, Maike; Hennig, Steffen; Mackensen, Andreas; Hummel, Michael; Moosmann, Andreas; Gerbitz, Armin.

PLoS Pathog ; 18(4): e1010206, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35452490

5.

Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53-deficient B-cell malignancies.

Izquierdo, Elena; Vorholt, Daniela; Blakemore, Stuart; Sackey, Benedict; Nolte, Janica L; Barbarino, Verena; Schmitz, Jan; Nickel, Nadine; Bachurski, Daniel; Lobastova, Liudmila; Nikolic, Milos; Michalik, Michael; Brinker, Reinhild; Merkel, Olaf; Franitza, Marek; Georgomanolis, Theodoros; Neuhaus, René; Koch, Maximilian; Nasada, Niklas; Knittel, Gero; Chapuy, Björn; Ludwig, Nicole; Meese, Eckart; Frenzel, Lukas; Reinhardt, Hans Christian; Peifer, Martin; Rebollido-Rios, Rocio; Bruns, Heiko; Krüger, Marcus; Hallek, Michael; Pallasch, Christian P.

Blood ; 139(25): 3617-3629, 2022 06 23.

Artigo em Inglês | MEDLINE | ID: mdl-35344582

6.

Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases.

Haskamp, Stefan; Bruns, Heiko; Hahn, Madelaine; Hoffmann, Markus; Gregor, Anne; Löhr, Sabine; Hahn, Jonas; Schauer, Christine; Ringer, Mark; Flamann, Cindy; Frey, Benjamin; Lesner, Adam; Thiel, Christian T; Ekici, Arif B; von Hörsten, Stephan; Aßmann, Gunter; Riepe, Claudia; Euler, Maximilien; Schäkel, Knut; Philipp, Sandra; Prinz, Jörg C; Mößner, Rotraut; Kersting, Florina; Sticherling, Michael; Sefiani, Abdelaziz; Lyahyai, Jaber; Sondermann, Wiebke; Oji, Vinzenz; Schulz, Peter; Wilsmann-Theis, Dagmar; Sticht, Heinrich; Schett, Georg; Reis, André; Uebe, Steffen; Frey, Silke; Hüffmeier, Ulrike.

Am J Hum Genet ; 107(3): 527-538, 2020 09 03.

Artigo em Inglês | MEDLINE | ID: mdl-32758447

7.

Upregulation of CCR4 in activated CD8⁺ T cells indicates enhanced lung homing in patients with severe acute SARS-CoV-2 infection.

Spoerl, Silvia; Kremer, Anita N; Aigner, Michael; Eisenhauer, Nina; Koch, Pauline; Meretuk, Lina; Löffler, Patrick; Tenbusch, Matthias; Maier, Clara; Überla, Klaus; Heinzerling, Lucie; Frey, Benjamin; Lutzny-Geier, Gloria; Winkler, Thomas H; Krönke, Gerhard; Vetter, Marcel; Bruns, Heiko; Neurath, Markus F; Mackensen, Andreas; Kremer, Andreas E; Völkl, Simon.

Eur J Immunol ; 51(6): 1436-1448, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-33784417

8.

Physiological levels of 25-hydroxyvitamin D₃ induce a suppressive CD4⁺ T cell phenotype not reflected in the epigenetic landscape.

Matos, Carina; Renner, Kathrin; Peuker, Alice; Schoenhammer, Gabriele; Schreiber, Laura; Bruss, Christina; Eder, Ruediger; Bruns, Heiko; Flamann, Cindy; Hoffmann, Petra; Gebhard, Claudia; Herr, Wolfgang; Rehli, Michael; Peter, Katrin; Kreutz, Marina.

Scand J Immunol ; 95(5): e13146, 2022 May.

Artigo em Inglês | MEDLINE | ID: mdl-35073416

9.

Treg depletion supercharges ASCT power.

Bruns, Heiko.

Blood ; 143(16): 1562-1563, 2024 Apr 18.

Artigo em Inglês | MEDLINE | ID: mdl-38635248

10.

The tyrosine kinase inhibitor dasatinib reduces the growth of intracellular Mycobacterium tuberculosis despite impairing T-cell function.

Wehrstedt, Stephanie; Kubis, Jan; Zimmermann, Andreas; Bruns, Heiko; Mayer, Daniel; Grieshober, Mark; Stenger, Steffen.

Eur J Immunol ; 48(11): 1892-1903, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30242834

11.

Detection of signature double-negative T cells is a predictive marker to identify autoimmune lymphoproliferative syndrome associated with FAS loss of function.

Eisenhauer, Nina; Miano, Maurizio; Naumann-Bartsch, Nora; Leyh, Jörg; Dell'Orso, Gianluca; Aigner, Michael; Fecker, Gisela; Hinze, Claas; Wittkowski, Helmut; Bruns, Heiko; Zierk, Jakob; Metzler, Markus; Arkwright, Peter D; Graw, Frederik; Mackensen, Andreas; Völkl, Simon.

Am J Hematol ; 99(5): 997-1000, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38481382

12.

Imatinib Triggers Phagolysosome Acidification and Antimicrobial Activity against Mycobacterium bovis Bacille Calmette-Guérin in Glucocorticoid-Treated Human Macrophages.

Steiger, Julia; Stephan, Alexander; Inkeles, Megan S; Realegeno, Susan; Bruns, Heiko; Kröll, Philipp; de Castro Kroner, Juliana; Sommer, Andrea; Batinica, Marina; Pitzler, Lena; Kalscheuer, Rainer; Hartmann, Pia; Plum, Georg; Stenger, Steffen; Pellegrini, Matteo; Brachvogel, Bent; Modlin, Robert L; Fabri, Mario.

J Immunol ; 197(1): 222-32, 2016 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-27233968

13.

Mesenchymal Stromal Cells Disrupt mTOR-Signaling and Aerobic Glycolysis During T-Cell Activation.

Böttcher, Martin; Hofmann, Andreas D; Bruns, Heiko; Haibach, Martina; Loschinski, Romy; Saul, Domenica; Mackensen, Andreas; Le Blanc, Katarina; Jitschin, Regina; Mougiakakos, Dimitrios.

Stem Cells ; 34(2): 516-21, 2016 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-26485560

14.

Direct aqueous measurement of 25-hydroxyvitamin D levels in a cellular environment by LC-MS/MS using the novel chemical derivatization reagent MDBP.

Müller, Miriam J; Bruns, Heiko; Volmer, Dietrich A.

Anal Bioanal Chem ; 409(10): 2705-2714, 2017 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-28138745

15.

Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia.

Jitschin, Regina; Hofmann, Andreas D; Bruns, Heiko; Giessl, Andreas; Bricks, Juliane; Berger, Jana; Saul, Domenica; Eckart, Michael J; Mackensen, Andreas; Mougiakakos, Dimitrios.

Blood ; 123(17): 2663-72, 2014 Apr 24.

Artigo em Inglês | MEDLINE | ID: mdl-24553174

16.

Labeling of cancer cells with magnetic nanoparticles for magnetic resonance imaging.

Weis, Christian; Blank, Fabian; West, Adrian; Black, Gregory; Woodward, Robert C; Carroll, Matthew R J; Mainka, Astrid; Kartmann, René; Brandl, Andreas; Bruns, Heiko; Hallam, Elizabeth; Shaw, Jeremy; Murphy, John; Teoh, Wey Yang; Aifantis, Katerina E; Amal, Rose; House, Mike; Pierre, Tim St; Fabry, Ben.

Magn Reson Med ; 71(5): 1896-905, 2014 May.

Artigo em Inglês | MEDLINE | ID: mdl-23813415

17.

Abelson tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages.

Bruns, Heiko; Stegelmann, Frank; Fabri, Mario; Döhner, Konstanze; van Zandbergen, Ger; Wagner, Manfred; Skinner, Mhairi; Modlin, Robert L; Stenger, Steffen.

J Immunol ; 189(8): 4069-78, 2012 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-22988030

18.

Enhanced potency of immunotherapy against B-cell precursor acute lymphoblastic leukemia by combination of an Fc-engineered CD19 antibody and CD47 blockade.

Schewe, Denis M; Vogiatzi, Fotini; Münnich, Ira A; Zeller, Tobias; Windisch, Roland; Wichmann, Christian; Müller, Kristina; Bhat, Hilal; Felix, Elisa; Mougiakakos, Dimitrios; Bruns, Heiko; Lenk, Lennart; Valerius, Thomas; Humpe, Andreas; Peipp, Matthias; Kellner, Christian.

Hemasphere ; 8(2): e48, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38435424

19.

Strain specific differences in vitamin D3 response: impact on gut homeostasis.

Schreiber, Laura; Ghimire, Sakhila; Hiergeist, Andreas; Renner, Kathrin; Althammer, Michael; Babl, Nathalie; Peuker, Alice; Schoenhammer, Gabriele; Hippe, Katrin; Gessner, Andre; Albrecht, Christin; Pielmeier, Fransziska; Büttner-Herold, Maike; Bruns, Heiko; Hoffmann, Petra; Herr, Wolfgang; Holler, Ernst; Peter, Katrin; Kreutz, Marina; Matos, Carina.

Front Immunol ; 15: 1347835, 2024.

Artigo em Inglês | MEDLINE | ID: mdl-38495883

20.

Gene network-based and ensemble modeling-based selection of tumor-associated antigens with a predicted low risk of tissue damage for targeted immunotherapy.

Lischer, Christopher; Eberhardt, Martin; Flamann, Cindy; Berges, Johannes; Güse, Esther; Wessely, Anja; Weich, Adrian; Retzlaff, Jimmy; Dörrie, Jan; Schaft, Niels; Wiesinger, Manuel; März, Johannes; Schuler-Thurner, Beatrice; Knorr, Harald; Gupta, Shailendra; Singh, Krishna Pal; Schuler, Gerold; Heppt, Markus Vincent; Koch, Elias Andreas Thomas; van Kleef, Nadine D; Freen-van Heeren, Julian J; Turksma, Annelies W; Wolkenhauer, Olaf; Hohberger, Bettina; Berking, Carola; Bruns, Heiko; Vera, Julio.

J Immunother Cancer ; 12(5)2024 May 09.

Artigo em Inglês | MEDLINE | ID: mdl-38724462

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