Detalhe da pesquisa
1.
Identification of Hetero-aggregates in Antibody Co-formulations by Multi-dimensional Liquid Chromatography Coupled to Mass Spectrometry.
Anal Chem
; 95(4): 2203-2212, 2023 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36669833
2.
Multi-Attribute Monitoring of Complex Erythropoetin Beta Glycosylation by GluC Liquid Chromatography-Mass Spectrometry Peptide Mapping.
Anal Chem
; 92(11): 7574-7580, 2020 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32426963
3.
Application of Hydrogen/Deuterium Exchange-Mass Spectrometry to Biopharmaceutical Development Requirements: Improved Sensitivity to Detection of Conformational Changes.
Anal Chem
; 89(16): 8233-8237, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28700824
4.
Detailed Characterization of Monoclonal Antibody Receptor Interaction Using Affinity Liquid Chromatography Hyphenated to Native Mass Spectrometry.
Anal Chem
; 89(10): 5404-5412, 2017 05 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28398745
5.
Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance.
Mol Pharm
; 14(4): 1292-1299, 2017 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28206769
6.
High-throughput work flow for IgG Fc-glycosylation analysis of biotechnological samples.
Anal Biochem
; 432(2): 82-9, 2013 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23026777
7.
Mass spectrometry-based multi-attribute method in protein therapeutics product quality monitoring and quality control.
MAbs
; 15(1): 2197668, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37057828
8.
Quantifying methionine sulfoxide in therapeutic protein formulation excipients as sensitive oxidation marker.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1189: 123092, 2022 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35026663
9.
Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability.
ACS Omega
; 7(4): 3671-3679, 2022 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35128275
10.
Comprehensive Multidimensional Liquid Chromatography-Mass Spectrometry for the Characterization of Charge Variants of a Bispecific Antibody.
J Am Soc Mass Spectrom
; 33(12): 2319-2327, 2022 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36442848
11.
Inter-laboratory study to evaluate the performance of automated online characterization of antibody charge variants by multi-dimensional LC-MS/MS.
Talanta
; 234: 122628, 2021 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34364437
12.
Multiattribute Monitoring of Antibody Charge Variants by Cation-Exchange Chromatography Coupled to Native Mass Spectrometry.
J Am Soc Mass Spectrom
; 32(8): 2062-2071, 2021 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33687195
13.
Recent advances in LC-MS based characterization of protein-based bio-therapeutics - mastering analytical challenges posed by the increasing format complexity.
J Pharm Biomed Anal
; 186: 113251, 2020 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32251978
14.
Subcellular fractionation of TGF-beta1-stimulated lung epithelial cells: a novel proteomic approach for identifying signaling intermediates.
Proteomics
; 9(5): 1230-40, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19253281
15.
The Impact of Immunoglobulin G1 Fc Sialylation on Backbone Amide H/D Exchange.
Antibodies (Basel)
; 8(4)2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31581521
16.
Effects of sialic acid linkage on antibody-fragment crystallizable receptor binding and antibody dependent cytotoxicity depend on levels of fucosylation/bisecting.
Bioanalysis
; 11(15): 1437-1449, 2019 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-31490109
17.
Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics.
MAbs
; 11(7): 1219-1232, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31339437
18.
Lung dendritic cells elicited by Fms-like tyrosine 3-kinase ligand amplify the lung inflammatory response to lipopolysaccharide.
Am J Respir Crit Care Med
; 176(9): 892-901, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17690334
19.
Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions.
Commun Biol
; 1: 28, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30271914
20.
Pyroglutamyl peptidase type I from Trypanosoma brucei: a new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts.
Biochem J
; 394(Pt 3): 635-45, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16248854