Detalhe da pesquisa
1.
Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.
Cell
; 146(3): 471-84, 2011 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-21816279
2.
Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement.
Chem Pharm Bull (Tokyo)
; 71(12): 879-886, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-38044140
3.
Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV.
J Hepatol
; 74(5): 1075-1086, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33333207
4.
Disruption of endocytosis through chemical inhibition of clathrin heavy chain function.
Nat Chem Biol
; 15(6): 641-649, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31011214
5.
Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants.
Antimicrob Agents Chemother
; 63(6)2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962341
6.
Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2' Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance.
Antimicrob Agents Chemother
; 63(8)2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31085520
7.
Disruption of adaptor protein 2µ (AP-2µ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing.
EMBO J
; 34(21): 2686-702, 2015 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26446278
8.
Reducing Macro- and Microheterogeneity of N-Glycans Enables the Crystal Structure of the Lectin and EGF-Like Domains of Human L-Selectin To Be Solved at 1.9â Å Resolution.
Chembiochem
; 18(13): 1338-1345, 2017 07 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28489325
9.
A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413.
Antimicrob Agents Chemother
; 60(12): 7046-7059, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27620483
10.
Synthesis of novel entecavir analogues having 4'-cyano-6''-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent.
RSC Adv
; 13(23): 15999-16011, 2023 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37265996
11.
Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties.
J Med Chem
; 66(19): 13516-13529, 2023 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37756225
12.
GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants.
Sci Adv
; 9(28): eadg2955, 2023 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37436982
13.
Identification of SARS-CoV-2 Mpro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2.
Nat Commun
; 14(1): 1076, 2023 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36841831
14.
Drug development targeting SARS-CoV-2 main protease.
Glob Health Med
; 4(6): 296-300, 2022 Dec 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36589216
15.
Regulation of Retroviral and SARS-CoV-2 Protease Dimerization and Activity through Reversible Oxidation.
Antioxidants (Basel)
; 11(10)2022 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36290777
16.
Potent and biostable inhibitors of the main protease of SARS-CoV-2.
iScience
; 25(11): 105365, 2022 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36338434
17.
GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans.
J Exp Med
; 219(6)2022 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35551368
18.
Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300.
bioRxiv
; 2021 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33851157
19.
Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300.
mBio
; 12(4): e0209421, 2021 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34399606
20.
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication.
Nat Commun
; 12(1): 668, 2021 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33510133