RESUMO
The Protein Data Bank (PDB) is the repository for three-dimensional structures of biological macromolecules, determined by experimental methods. The data in the archive is free and easily available via the Internet from any of the worldwide centers managing this global archive. These data are used by scientists, researchers, bioinformatics specialists, educators, students, and general audiences to understand biological phenomenon at a molecular level. Analysis of this structural data also inspires and facilitates new discoveries in science. This chapter describes the tools and methods currently used for deposition, processing, and release of data in the PDB. References to future enhancements are also included.
Assuntos
Bases de Dados de Proteínas , Armazenamento e Recuperação da Informação/métodos , Proteínas/química , Biologia Computacional , Documentação , Reprodutibilidade dos TestesRESUMO
The Protein Data Bank (PDB) is the repository for the three-dimensional structures of biological macromolecules, determined by experimental methods. The data in the archive are free and easily available via the Internet from any of the worldwide centers managing this global archive. These data are used by scientists, researchers, bioinformatics specialists, educators, students, and lay audiences to understand biological phenomena at a molecular level. Analysis of these structural data also inspires and facilitates new discoveries in science. This chapter describes the tools and methods currently used for deposition, processing, and release of data in the PDB. References to future enhancements are also included.
Assuntos
Bases de Dados de Proteínas , Documentação/métodos , Armazenamento e Recuperação da Informação/métodos , Conformação Proteica , Proteínas/químicaAssuntos
Biologia Computacional/métodos , Sistemas de Gerenciamento de Base de Dados , Bases de Dados de Proteínas , Documentação/métodos , Proteínas/química , Proteínas/classificação , Indexação e Redação de Resumos/métodos , Sequência de Aminoácidos , Comportamento Cooperativo , Dados de Sequência Molecular , Pesquisa , Relação Estrutura-AtividadeRESUMO
The Protein Data Bank [PDB; Berman, Westbrook et al. (2000), Nucleic Acids Res. 28, 235-242; http://www.pdb.org/] is the single worldwide archive of primary structural data of biological macromolecules. Many secondary sources of information are derived from PDB data. It is the starting point for studies in structural bioinformatics. This article describes the goals of the PDB, the systems in place for data deposition and access, how to obtain further information and plans for the future development of the resource. The reader should come away with an understanding of the scope of the PDB and what is provided by the resource.