Detalhe da pesquisa
1.
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
Bioorg Med Chem Lett
; 22(23): 7207-13, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23084906
2.
Development of potent macrocyclic inhibitors of genotype 3a HCV NS3/4A protease.
Bioorg Med Chem Lett
; 22(23): 7201-6, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23021993
3.
Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists.
Bioorg Med Chem Lett
; 19(17): 5132-5, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19648007
4.
Molecular modeling based approach to potent P2-P4 macrocyclic inhibitors of hepatitis C NS3/4A protease.
J Am Chem Soc
; 130(14): 4607-9, 2008 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-18338894
5.
Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma.
ACS Med Chem Lett
; 9(7): 679-684, 2018 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30034600
6.
Identification and characterization of 4-methylbenzyl 4-[(pyrimidin-2-ylamino)methyl]piperidine-1-carboxylate, an orally bioavailable, brain penetrant NR2B selective N-methyl-D-aspartate receptor antagonist.
J Med Chem
; 50(4): 807-19, 2007 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17249648
7.
Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors.
J Med Chem
; 58(4): 1929-39, 2015 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25625541
8.
P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: discovery of MK-2748 and MK-6325.
ChemMedChem
; 10(4): 727-35, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25759009
9.
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.
ACS Med Chem Lett
; 3(4): 332-6, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900473
10.
Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure.
ACS Med Chem Lett
; 2(3): 207-12, 2011 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900304
11.
Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor.
J Med Chem
; 53(6): 2443-63, 2010 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20163176
12.
Synthesis of the first sulfur-35-labeled hERG radioligand.
Bioorg Med Chem Lett
; 16(6): 1692-5, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16377185
13.
Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I(Ks)-blocking class III antiarrhythmic agents.
Bioorg Med Chem Lett
; 13(6): 1165-8, 2003 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12643935
14.
A new series of potent benzodiazepine gamma-secretase inhibitors.
Bioorg Med Chem Lett
; 13(2): 179-83, 2003 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12482419