Detalhe da pesquisa
1.
Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors.
J Biol Chem
; 298(10): 102375, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35970392
2.
Pioneering first-in-class FAAH-HDAC inhibitors as potential multitarget neuroprotective agents.
Arch Pharm (Weinheim)
; 356(12): e2300410, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37750286
3.
Development of Quinazolinone Derivatives as Modulators of Virulence Factors of Pseudomonas aeruginosa Cystic Fibrosis Strains.
Molecules
; 28(18)2023 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37764311
4.
A Therapeutic Perspective of HDAC8 in Different Diseases: An Overview of Selective Inhibitors.
Int J Mol Sci
; 23(17)2022 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36077415
5.
Covalent Reversible Inhibitors of Cysteine Proteases Containing the Nitrile Warhead: Recent Advancement in the Field of Viral and Parasitic Diseases.
Molecules
; 27(8)2022 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35458759
6.
Total Synthesis of the Natural Chalcone Lophirone E, Synthetic Studies toward Benzofuran and Indole-Based Analogues, and Investigation of Anti-Leishmanial Activity.
Molecules
; 27(2)2022 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35056779
7.
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eµ-TCL1 mice through the JNK/STAT4/p66Shc axis.
Pharmacol Res
; 174: 105965, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34732370
8.
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas.
Med Res Rev
; 40(3): 1002-1060, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31742748
9.
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II).
Bioorg Chem
; 89: 103020, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31185392
10.
iPSC-derived neurons profiling reveals GABAergic circuit disruption and acetylated α-tubulin defect which improves after iHDAC6 treatment in Rett syndrome.
Exp Cell Res
; 368(2): 225-235, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29730163
11.
A Repurposing Approach for Uncovering the Anti-Tubercular Activity of FDA-Approved Drugs with Potential Multi-Targeting Profiles.
Molecules
; 24(23)2019 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31795400
12.
Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells.
Invest New Drugs
; 34(5): 663-76, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27334143
13.
The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15.
Invest New Drugs
; 34(2): 159-67, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26885657
14.
Targeting clinically-relevant metallo-ß-lactamases: from high-throughput docking to broad-spectrum inhibitors.
J Enzyme Inhib Med Chem
; 31(sup1): 98-109, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27121013
15.
Exploring clotrimazole-based pharmacophore: 3D-QSAR studies and synthesis of novel antiplasmodial agents.
Bioorg Med Chem Lett
; 25(22): 5412-8, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26428874
16.
Rational design of the first difluorostatone-based PfSUB1 inhibitors.
Bioorg Med Chem Lett
; 24(15): 3582-6, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24909083
17.
Metalloenzyme Inhibitors against Zoonotic Infections: Focus on Leishmania and Schistosoma.
ACS Infect Dis
; 10(5): 1520-1535, 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38669567
18.
Synthetic derivatives of natural cinnamic acids as potential anti-colorectal cancer agents.
Chem Biol Drug Des
; 103(1): e14415, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38230797
19.
Traceability and authentication in agri-food production: A multivariate approach to the characterization ofthe Italian food excellence elephant garlic (Allium ampeloprasum L.), a vasoactive nutraceutical.
Food Chem
; 444: 138684, 2024 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38359701
20.
A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients.
Biomed Pharmacother
; 174: 116537, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38579402