Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes.

Blencowe, Montgomery; Furterer, Allison; Wang, Qing; Gao, Fuying; Rosenberger, Madeline; Pei, Lina; Nomoto, Hiroshi; Mawla, Alex M; Huising, Mark O; Coppola, Giovanni; Yang, Xia; Butler, Peter C; Gurlo, Tatyana.

Diabetologia ; 65(1): 173-187, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34554282

2.

Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes.

Nomoto, Hiroshi; Pei, Lina; Montemurro, Chiara; Rosenberger, Madeline; Furterer, Allison; Coppola, Giovanni; Nadel, Brian; Pellegrini, Matteo; Gurlo, Tatyana; Butler, Peter C; Tudzarova, Slavica.

Diabetologia ; 63(1): 149-161, 2020 01.

Artigo em Inglês | MEDLINE | ID: mdl-31720731

3.

Pregnancy in human IAPP transgenic mice recapitulates beta cell stress in type 2 diabetes.

Gurlo, Tatyana; Kim, Sarah; Butler, Alexandra E; Liu, Chang; Pei, Lina; Rosenberger, Madeline; Butler, Peter C.

Diabetologia ; 62(6): 1000-1010, 2019 06.

Artigo em Inglês | MEDLINE | ID: mdl-30852627

4.

Supplying Insulin while Evading Immunity.

Butler, Peter C.

N Engl J Med ; 384(10): 967-969, 2021 03 11.

Artigo em Inglês | MEDLINE | ID: mdl-33704943

5.

In the setting of ß-cell stress, the pancreatic duct gland transcriptome shows characteristics of an activated regenerative response.

Butler, Alexandra E; Kirakossian, David; Gurlo, Tatyana; Gao, Fuying; Coppola, Giovanni; Butler, Peter C.

Am J Physiol Gastrointest Liver Physiol ; 315(5): G848-G854, 2018 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-30095296

6.

Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption.

Kegulian, Natalie C; Sankhagowit, Shalene; Apostolidou, Melania; Jayasinghe, Sajith A; Malmstadt, Noah; Butler, Peter C; Langen, Ralf.

J Biol Chem ; 290(43): 25782-93, 2015 Oct 23.

Artigo em Inglês | MEDLINE | ID: mdl-26283787

7.

Evaluation of immunohistochemical staining for glucagon in human pancreatic tissue.

Gurlo, Tatyana; Butler, Peter C; Butler, Alexandra E.

J Histotechnol ; 39(1): 8-16, 2016.

Artigo em Inglês | MEDLINE | ID: mdl-27182095

8.

Recovery of high-quality RNA from laser capture microdissected human and rodent pancreas.

Butler, Alexandra E; Matveyenko, Aleksey V; Kirakossian, David; Park, Johanna; Gurlo, Tatyana; Butler, Peter C.

J Histotechnol ; 39(2): 59-65, 2016.

Artigo em Inglês | MEDLINE | ID: mdl-27231405

9.

Application of fluorescence lifetime imaging microscopy to monitor glucose metabolism in pancreatic islets in vivo.

Wang, Zhongying; Archang, Maani; Gurlo, Tatyana; Wong, Elaine; Fraser, Scott E; Butler, Peter C.

Biomed Opt Express ; 14(8): 4170-4178, 2023 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-37799700

10.

Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide.

Gurlo, Tatyana; Prakash, Thazha P; Wang, Zhongying; Archang, Maani; Pei, Lina; Rosenberger, Madeline; Pirie, Elaine; Lee, Richard G; Butler, Peter C.

Front Mol Biosci ; 10: 1096286, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-36814640

11.

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis.

Haataja, Leena; Gurlo, Tatyana; Huang, Chang J; Butler, Peter C.

Endocr Rev ; 29(3): 303-16, 2008 May.

Artigo em Inglês | MEDLINE | ID: mdl-18314421

12.

Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies.

Elashoff, Michael; Matveyenko, Aleksey V; Gier, Belinda; Elashoff, Robert; Butler, Peter C.

Gastroenterology ; 141(1): 150-6, 2011 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-21334333

13.

Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.

Huang, Chang-jiang; Gurlo, Tatyana; Haataja, Leena; Costes, Safia; Daval, Marie; Ryazantsev, Sergey; Wu, Xiuji; Butler, Alexandra E; Butler, Peter C.

J Biol Chem ; 285(1): 339-48, 2010 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-19861418

14.

Shortened {beta}-cell lifespan leads to {beta}-cell deficit in a rodent model of type 2 diabetes.

Manesso, Erica; Toffolo, Gianna M; Butler, Alexandra E; Butler, Peter C; Cobelli, Claudio.

Am J Physiol Endocrinol Metab ; 300(5): E933-8, 2011 May.

Artigo em Inglês | MEDLINE | ID: mdl-21343541

15.

Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway.

Gurlo, Tatyana; Ryazantsev, Sergey; Huang, Chang-jiang; Yeh, Michael W; Reber, Howard A; Hines, O Joe; O'Brien, Timothy D; Glabe, Charles G; Butler, Peter C.

Am J Pathol ; 176(2): 861-9, 2010 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-20042670

16.

The ß-cell glucose toxicity hypothesis: Attractive but difficult to prove.

Weir, Gordon C; Butler, Peter C; Bonner-Weir, Susan.

Metabolism ; 124: 154870, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34480921

17.

Live-cell imaging of glucose-induced metabolic coupling of ß and α cell metabolism in health and type 2 diabetes.

Wang, Zhongying; Gurlo, Tatyana; Matveyenko, Aleksey V; Elashoff, David; Wang, Peiyu; Rosenberger, Madeline; Junge, Jason A; Stevens, Raymond C; White, Kate L; Fraser, Scott E; Butler, Peter C.

Commun Biol ; 4(1): 594, 2021 05 19.

Artigo em Inglês | MEDLINE | ID: mdl-34012065

18.

Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats.

Matveyenko, Aleksey V; Georgia, Senta; Bhushan, Anil; Butler, Peter C.

Am J Physiol Endocrinol Metab ; 299(5): E713-20, 2010 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-20587750

19.

Visualizing insulin vesicle neighborhoods in ß cells by cryo-electron tomography.

Zhang, Xianjun; Carter, Stephen D; Singla, Jitin; White, Kate L; Butler, Peter C; Stevens, Raymond C; Jensen, Grant J.

Sci Adv ; 6(50)2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-33298442

20.

Pancreatic alpha-cell mass across adult human lifespan.

Moin, Abu Saleh Md; Cory, Megan; Gurlo, Tatyana; Saisho, Yoshifumi; Rizza, Robert A; Butler, Peter C; Butler, Alexandra E.

Eur J Endocrinol ; 182(2): 219-231, 2020 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-31821160

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