Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases.

PURPOSE: Interleukin-6 (IL-6) production and signalling are increased in the inflamed mucosa in inflammatory bowel diseases (IBD). As published serum levels of IL-6 and its soluble receptors sIL-6R and sgp130 in IBD are from small cohorts and partly contradictory, we systematically evaluated IL-6, sIL-6R and sgp130 levels as markers of disease activity in Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Consecutive adult outpatients with confirmed CD or UC were included, and their disease activity and medication were monitored. Serum from 212 CD patients (815 measurements) and 166 UC patients (514 measurements) was analysed, and 100 age-matched healthy blood donors were used as controls. RESULTS: IL-6 serum levels were significantly elevated in active versus inactive CD and UC, also compared with healthy controls. However, only a fraction of IBD patients showed increased serum IL-6. IL-6 levels ranged up to 32.7 ng/mL in active CD (> 5000-fold higher than in controls), but also up to 6.9 ng/mL in inactive CD. Increases in active UC (up to 195 pg/mL) and inactive UC (up to 27 pg/mL) were less pronounced. Associations between IL-6 serum levels and C-reactive protein concentrations as well as leukocyte and thrombocyte counts were observed. Median sIL-6R and sgp130 levels were only increased by up to 15%, which was considered of no diagnostic significance. CONCLUSIONS: Only a minority of IBD patients shows elevated IL-6 serum levels. However, in these patients, IL-6 is strongly associated with disease activity. Its soluble receptors sIL-6R and sgp130 do not appear useful as biomarkers in IBD.

To prophylactically extract or not to extract partially erupted mesio-angularly impacted lower third molars?

Introduction Prophylactic removal of mesio-angularly impacted mandibular third molars (MAIM3Ms) has been discouraged by the National Institute for Health and Care Excellence in 2000. Consequently, partially erupted MAIM3Ms are retained for longer and only extracted if complications arise. The debate whether to extract prophylactically or to monitor these teeth is ongoing.Pathologies associated with retained partially erupted MAIM3Ms Retaining third molars long into adulthood has been associated with an increased risk of distal cervical caries and external root resorption of the second molar, periodontal disease and pericoronitis, among other pathologies. Although watchful monitoring can help to identify these pathologies, their nature often leads not only to a poor prognosis for the third molar, but also for the second molar, which then requires costly and time-consuming restorative or even prosthodontic work.Considering prophylactic extractions While an individual risk assessment is paramount, prophylactic removal of partially erupted MAIM3Ms has been shown to have positive effects on oral health-related quality of life, to relieve the pressure on secondary care services and to be economically feasible for the NHS.Conclusion While long-term prospective cohort studies are necessary to put an end to the ongoing controversy, patients' needs and wishes should be at the forefront of the provision of care.