Detalhe da pesquisa
1.
Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii.
Antimicrob Agents Chemother
; 63(10)2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31383666
2.
Virtual Screening and Experimental Testing of B1 Metallo-ß-lactamase Inhibitors.
J Chem Inf Model
; 58(9): 1902-1914, 2018 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30107123
3.
Activity of the ß-Lactamase Inhibitor LN-1-255 against Carbapenem-Hydrolyzing Class D ß-Lactamases from Acinetobacter baumannii.
Antimicrob Agents Chemother
; 61(11)2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28807908
4.
LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48.
J Antimicrob Chemother
; 71(8): 2171-80, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27125555
5.
Functionalizing the γ-Position of α-Diazo-ß-ketoesters.
Tetrahedron Lett
; 57(30): 3330-3333, 2016 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27956752
6.
Detecting a quasi-stable imine species on the reaction pathway of SHV-1 ß-lactamase and 6ß-(hydroxymethyl)penicillanic acid sulfone.
Biochemistry
; 54(3): 734-43, 2015 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25536850
7.
Meropenem and chromacef intermediates observed in IMP-25 metallo-ß-lactamase-catalyzed hydrolysis.
Antimicrob Agents Chemother
; 59(7): 4326-30, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25918145
8.
Triethysilyl Enol Ethers in the Synthesis of Carbapenem Precursors.
Tetrahedron Lett
; 56(23): 3385-3389, 2015 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26034332
9.
Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase.
ACS Infect Dis
; 10(4): 1232-1249, 2024 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38511828
10.
ß-Lactamase inhibition by 7-alkylidenecephalosporin sulfones: allylic transposition and formation of an unprecedented stabilized acyl-enzyme.
J Am Chem Soc
; 135(49): 18358-69, 2013 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24219313
11.
The C5α-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases.
ACS Infect Dis
; 9(5): 1123-1136, 2023 05 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37130087
12.
Carboxylation and decarboxylation of active site Lys 84 controls the activity of OXA-24 ß-lactamase of Acinetobacter baumannii: Raman crystallographic and solution evidence.
J Am Chem Soc
; 134(27): 11206-15, 2012 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-22702961
13.
Crystal structures of KPC-2 ß-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226.
Antimicrob Agents Chemother
; 56(5): 2713-8, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22330909
14.
Early insights into the interactions of different ß-lactam antibiotics and ß-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3.
Antimicrob Agents Chemother
; 56(11): 5687-92, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22908165
15.
C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation.
mBio
; 13(3): e0036722, 2022 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35420470
16.
Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.
Antimicrob Agents Chemother
; 55(5): 2303-9, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21357298
17.
Modifications of the C6-substituent of penicillin sulfones with the goal of improving inhibitor recognition and efficacy.
Bioorg Med Chem Lett
; 21(1): 387-93, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21129961
18.
Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination with the ß-Lactamase Inhibitor LN-1-255 against Acinetobacter spp.
Antibiotics (Basel)
; 10(2)2021 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33672671
19.
Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of ß-Lactamase Inhibitors.
ACS Infect Dis
; 7(8): 2425-2436, 2021 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34191496
20.
Design, synthesis, and crystal structures of 6-alkylidene-2'-substituted penicillanic acid sulfones as potent inhibitors of Acinetobacter baumannii OXA-24 carbapenemase.
J Am Chem Soc
; 132(38): 13320-31, 2010 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-20822105