RESUMO
Rats with lesions of the dorsomedial nucleus of the hypothalamus (DMN-L) are hypophagic and have reduced linear growth and body weight, but normal body composition. Male Sprague-Dawley rats (170-190 g) housed individually under a 12:12 L:D schedule with lights out at 1430 hr received jugular cannulas, and on return to precannulation body weight (4.2 +/- 0.6 days), they received bilateral electrolytic DMN-L or sham-operations (SHAM). Rats with DMN-L (n = 8) were hypophagic postsurgery and weight less (p less than 0.05) than SHAM at six days postlesion surgery. The difference in body weight between the two groups continued to expand over the next four weeks. Six days postsurgery, the rats were bled (RBC's returned in 10% BSA-saline) every 15 minutes between 0600-1215 hr and growth hormone (GH) subsequently assayed. The total GH secretion, as computed from the area under each rat's ultradian pattern, was similar in both groups (DMN-L versus SHAM, 2952.2 +/- 346.5 versus 2950.4 +/- 337.5). Using the PULSAR computer program, the baseline secretion (12.2 +/- 4.0 versus 11.8 +/- 2.7 ng/ml), total number of peaks (2.4 +/- 0.4 versus 2.4 +/- 0.2), and interpeak interval (2.8 +/- 0.5 versus 2.7 +/- 0.4, hr) were not significantly different between the DMN-L and SHAM rats, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Assuntos
Núcleo Hipotalâmico Dorsomedial/fisiologia , Comportamento Alimentar/fisiologia , Hormônio do Crescimento/metabolismo , Hipotálamo Médio/fisiologia , Animais , Peso Corporal/fisiologia , Hormônio do Crescimento/sangue , Masculino , Periodicidade , Ratos , Ratos EndogâmicosRESUMO
The lungs are a common target in many rheumatic diseases. Treatment of the primary rheumatic disease is often all that is required to control lung involvement. Physicians must be careful not to attribute lung disease to the underlying rheumatic disorder, because interstitial lung disease can be a complication of drug therapy.
Assuntos
Doenças do Tecido Conjuntivo/complicações , Pneumopatias/complicações , Doenças Reumáticas/complicações , Artrite Reumatoide/complicações , Hemorragia/complicações , Humanos , Pneumopatias/diagnóstico , Pneumopatias/terapia , Doenças Pleurais/diagnóstico , Doenças Pleurais/etiologia , Fibrose Pulmonar/complicações , Nódulo Pulmonar Solitário/complicaçõesRESUMO
In brief As part of a comprehensive brief treatment plan, exercise can decrease pain and improve function in people who have rheumatoid arthritis or osteoarthritis. The physician must prescribe an individualized, realistic, and enjoyable exercise program that helps the affected joints and builds fitness. Well-tailored recommendations can also help maximize patient compliance. The physician must also provide appropriate follow-up care, adjusting the exercise program and medications as needed.