1.
Chem Commun (Camb)
; 59(23): 3415-3418, 2023 Mar 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36852903
RESUMO
Nitroxyl (HNO) is a short-lived mediator of cell signalling and can enhance the sulfane sulfur pool, a cellular antioxidant reservoir, by reacting with hydrogen sulfide (H2S). Here, we report esterase-activated HNO-generators that are suitable for tunable HNO release and the design of these donors allows for real-time monitoring of HNO release. These tools will help gain a better understanding of the cross-talk among short-lived gaseous signalling molecules that have emerged as major players in health and disease.