Detalhe da pesquisa
1.
Intra-islet glucagon confers ß-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon.
J Biol Chem
; 298(2): 101484, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34896391
2.
Catechol estrogens stimulate insulin secretion in pancreatic ß-cells via activation of the transient receptor potential A1 (TRPA1) channel.
J Biol Chem
; 294(8): 2935-2946, 2019 02 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30587572
3.
GABA promotes ß-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity.
FASEB J
; 33(3): 3968-3984, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30509117
4.
γ-aminobutyric acid stimulates ß-cell proliferation through the mTORC1/p70S6K pathway, an effect amplified by Ly49, a novel γ-aminobutyric acid type A receptor positive allosteric modulator.
Diabetes Obes Metab
; 22(11): 2021-2031, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32558194
5.
Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles.
J Biol Chem
; 291(20): 10700-15, 2016 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26975372
6.
The Different Faces of the Pancreatic Islet.
Adv Exp Med Biol
; 938: 11-24, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27586419
7.
Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function.
Proc Natl Acad Sci U S A
; 109(52): 21456-61, 2012 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23236142
8.
ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cell.
Proc Natl Acad Sci U S A
; 107(14): 6465-70, 2010 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-20308565
9.
Identification of biomarkers for glycaemic deterioration in type 2 diabetes.
Nat Commun
; 14(1): 2533, 2023 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37137910
10.
Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes.
BMC Genomics
; 12: 281, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21631939
11.
GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice.
J Clin Invest
; 131(12)2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34003802
12.
Glucose Regulates Microtubule Disassembly and the Dose of Insulin Secretion via Tau Phosphorylation.
Diabetes
; 69(9): 1936-1947, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32540877
13.
Automated, high-throughput assays for evaluation of human pancreatic islet function.
Cell Transplant
; 16(10): 1039-48, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18351020
14.
LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept.
Mol Metab
; 18: 3-14, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30473097
15.
Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus.
J Med Chem
; 61(3): 934-945, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29236497
16.
Interference with tissue factor prolongs intrahepatic islet allograft survival in a nonhuman primate marginal mass model.
Transplantation
; 84(3): 308-15, 2007 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17700154
17.
Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5.
Endocrinology
; 158(11): 3859-3873, 2017 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28938487
18.
Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.
Mol Endocrinol
; 29(7): 988-1005, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26061564
19.
Human, nonhuman primate, and rat pancreatic islets express erythropoietin receptors.
Transplantation
; 75(8): 1356-60, 2003 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-12717230
20.
The Complex Viral Etiology of St. Augustine Decline.
Plant Dis
; 83(10): 902-904, 1999 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-30841070