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1.
Clin Orthop Relat Res ; 476(2): 261-278, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29529655

RESUMO

BACKGROUND: In 2010, a widely used metal-on-metal hip implant design was voluntarily recalled by the manufacturer because of higher than anticipated failure rates at 5 years. Although there was a large published range of revision rates, numerous studies had reported a higher risk of revision for excessive wear and associated adverse tissue reactions when compared with other metal-on-metal total hips. The reasons for this were suggested by some to be related to cup design features. QUESTIONS/PURPOSES: From retrievals of ASR metal-on-metal implants and tissue samples obtained at revision surgery, we asked the following questions: (1) What were the common and uncommon surface features? (2) What were the common and uncommon linear and volumetric wear characteristics? (3) Were there common taper corrosion characteristics? (4) What aseptic lymphocytic vasculitis-associated lesion (ALVAL) features were present in the tissues? METHODS: Five hundred fifty-five ASRs, including 23 resurfacings, were studied at one academic research center. Features of wear (eg, light and moderate scratching), damage (eg, deposits, gouges), and bone attachment on the porous coating were semiquantitatively ranked from 0 (none) to 3 (> 75%) based on the amount of a feature in each region of interest by the same experienced observer throughout the study. Visible features of head taper corrosion were ranked (Goldberg score) from 1 (none) to 4 (severe) by the same observer using a previously published scoring method. An experienced tribologist measured component wear depth using a coordinate measuring machine and quantified wear volume using previously validated methods. All available tissues were sampled and examined for features of ALVAL and scored from 0 to 10 by a single observer using a method they previously developed and published. A score from 0 to 4 is considered low, 5 to 8 is considered moderate, and 9 or 10 is considered high with regard to the risk of metal hypersensitivity features in the tissues. RESULTS: The most common bearing surface features were light and moderate scratches and removal or postremoval damage. Discoloration and deposits were commonly observed on femoral heads (55% [305 of 553]) and less commonly on cups (30% [165 of 546]). There was no evidence of impingement or dislocation damage. There was typically a small amount of bone attachment in at least one of eight designated regions of interest (84% [460 of 546]); extensive or no bone attachment was uncommon. Edge wear was highly prevalent. The maximum wear of 469 cups (88%) occurred near the edge, whereas the maximum wear of 508 femoral heads (94%) occurred between the pole and 45° from the pole. The median combined head-cup wear volume was 14 mm (range, 1-636 mm). One hundred sixty-nine pairs (32%) had a combined wear volume of < 10 mm, 42 pairs (8%) had volumetric wear of > 100 mm, and 319 pairs (60%) had wear volume between 10 and 100 mm³. Seventy-four percent of tapers (390 of 530) received a Goldberg score of 4, 22% (116 of 530) a score of 3, < 5% (24 of 530) a score of 2, and none received a score of 1. The most frequent ALVAL score was 5 out of 10 (35 of 144 hips [24%]) and ranged from 2 (one hip) to 10 (nine hips); 92 of 144 (64%) had a moderate score, 17 of 144 (12%) had a high score, and 35 (24%) had a low score. CONCLUSIONS: Although edge wear was prevalent, in most cases, this was not associated with high wear. The increased diameter and decreased coverage angle of the ASR design may have resulted in the observed high incidence of edge wear while perhaps decreasing the risk for impingement and dislocation. CLINICAL RELEVANCE: The role of bearing wear in the revisions of metal-on-metal implants is controversial, because it is known that there is a large range of in vivo wear rates even within the same implant type and that patient variability affects local tissue responses to wear debris. The observations from our study of 555 retrieved ASR implant sets indicate that there was a wide range of wear including a subset with very high wear. The results suggested that the failure of the ASR and ASR XL was multifactorial, and the failure of different subgroups such as those with low wear may be the result of mechanisms other than reaction to wear debris.


Assuntos
Artroplastia de Quadril/efeitos adversos , Artroplastia de Quadril/instrumentação , Remoção de Dispositivo , Articulação do Quadril/cirurgia , Prótese de Quadril , Próteses Articulares Metal-Metal , Falha de Prótese , Vasculite/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Análise de Falha de Equipamento , Feminino , Articulação do Quadril/fisiopatologia , Humanos , Masculino , Recall de Dispositivo Médico , Pessoa de Meia-Idade , Desenho de Prótese , Reoperação , Fatores de Risco , Estresse Mecânico , Propriedades de Superfície , Fatores de Tempo , Resultado do Tratamento , Vasculite/diagnóstico , Vasculite/etiologia , Adulto Jovem
2.
Clin Orthop Relat Res ; 472(12): 3687-98, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25080263

RESUMO

BACKGROUND: The biologic reactions to byproducts of wear or corrosion can involve innate and adaptive processes and are dependent on many factors, including the composition, size, surface properties, shape, and concentration of debris. QUESTIONS/PURPOSES: We used a systematic literature review to compare the reported patterns of inflammation in tissues around total hip implants with the goal of identifying whether there are unique or characteristic patterns associated with the newer bearing options or modular components. METHODS: A search of the Ovid Medline database between 1996 and early December 2013 identified articles that compared the histology around six implant groups: (1) metal-on-metal; (2) ceramic-on-ceramic; (3) metal-on-crosslinked polyethylene; (4) metal-on-conventional polyethylene with or (5) without modularity; and (6) tissue obtained at primary arthroplasty. Our initial search yielded 865 citations. After excluding articles that lacked a quantitative or semiquantitative description of histologic findings in periprosthetic tissue, we reviewed 34 articles. RESULTS: No pattern of inflammation is specific for any given bearing combination. Histologic features suggestive of an adaptive immune response appear to be more frequent and of greater magnitude in failed metal-on-metal implants, but tissues around many failed metal-on-metal implants show features of an "innate" foreign body reaction without lymphocytes. Occasional nonmetal-on-metal implants show features of an immune reaction, possibly associated with metal particles. Modular connections are one source of metal debris in nonmetal-on-metal implants. Features of an immune reaction appear rare in ceramic-on-ceramic implants that lack corrosion. Insufficient reports are available to characterize the biologic response to crosslinked polyethylene. CONCLUSIONS: All total hip bearing combinations will wear in vivo, and modular interfaces are a likely source of metal that may be associated with a biological response regardless of the composition of the bearing surfaces. Surgeons must weigh the potential advantages of each articular combination and modular connection with the potential adverse tissue reactions in any given patient. Additional work is needed to clarify the implant and host-related factors associated with adverse tissue reactions and that seem to induce an immune reaction in some patients.


Assuntos
Artroplastia de Quadril/instrumentação , Migração de Corpo Estranho/etiologia , Articulação do Quadril/cirurgia , Prótese de Quadril , Falha de Prótese , Imunidade Adaptativa , Animais , Artroplastia de Quadril/efeitos adversos , Fenômenos Biomecânicos , Cerâmica , Corrosão , Migração de Corpo Estranho/diagnóstico , Migração de Corpo Estranho/imunologia , Articulação do Quadril/fisiopatologia , Humanos , Imunidade Inata , Próteses Articulares Metal-Metal , Polietileno , Desenho de Prótese , Fatores de Risco , Estresse Mecânico , Propriedades de Superfície , Resultado do Tratamento
3.
Clin Orthop Relat Res ; 472(12): 3718-27, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25160942

RESUMO

BACKGROUND: Metal-on-metal (MoM) total hip arthroplasties (THAs) and the head-neck and neck-body junctions in modular THA are associated with a variety of local and systemic reactions to their related wear and corrosion products. Although laboratory testing is available, the relationship between laboratory values--including serum metal ion levels--and adverse local tissue reactions (ALTRs) remains controversial and incompletely characterized. QUESTIONS/PURPOSES: (1) What is the range of serum metal levels associated with ALTR in patients who have MoM THAs or corrosion at the head-neck and neck-body junctions in metal-on-polyethylene (or ceramic-on-polyethylene) THAs? (2) How much wear occurs in patients with MoM total hips? (3) Is there evidence of a dose-response relationship between wear and ALTR? METHODS: PubMed and Embase databases were reviewed for English-language studies assessing serum metal levels in the presence of ALTR and papers describing the results of wear measurements from revised MoM implants and ALTR histopathology were systematically reviewed. Reported linear wear data were separated into groups with ALTR and without ALTR as listed in individual papers and graphed to determine whether a dose-response relationship was present between wear and ALTR. Overall, 15 studies including 338 hips with ALTR with corresponding serum metal levels were identified and analyzed. Twelve studies reported the wear depth or volume of MoM components from patients with a variety of local reactions. Two studies investigated corrosion at the head-neck and neck-body junctions in metal-on-polyethylene THA. There was a high level of variability and study heterogeneity, and so data pooling (meta-analysis) could not be performed. RESULTS: Average reported metal concentrations were elevated above established normal values in patients with ALTR (cobalt concentrations ranged from 5 to 40 ppb, and chromium levels ranged from 5 to 54 ppb). Whereas several studies demonstrated that patients with ALTR had higher average linear wear of the bearing surfaces, this finding was not made in all studies that we identified in this systematic review. Because of this high degree of variability, no clear dose-response relationship between wear and ALTR could be established. CONCLUSIONS: Serum metal level analysis and implant retrieval analysis both contribute to the understanding of ALTR. Serum metal levels generally are elevated in the presence of ALTR but should not be used in isolation for clinical decision-making. Many but not all patients with ALTR, including those with pseudotumors, demonstrate high wear, but more data and more systematic descriptions of the histopathology are needed to define the amount of wear that induces adverse reactions.


Assuntos
Artroplastia de Quadril/instrumentação , Remoção de Dispositivo , Reação a Corpo Estranho/etiologia , Articulação do Quadril/cirurgia , Prótese de Quadril , Próteses Articulares Metal-Metal , Metais/sangue , Falha de Prótese , Artroplastia de Quadril/efeitos adversos , Biomarcadores/sangue , Fenômenos Biomecânicos , Cerâmica , Reação a Corpo Estranho/sangue , Reação a Corpo Estranho/diagnóstico , Reação a Corpo Estranho/cirurgia , Articulação do Quadril/fisiopatologia , Humanos , Polietileno , Valor Preditivo dos Testes , Desenho de Prótese , Reoperação , Fatores de Risco , Estresse Mecânico , Resultado do Tratamento
4.
J Arthroplasty ; 29(4): 802-7, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24090660

RESUMO

Due to the well-documented problems surrounding metal-on-metal bearings, the use of hip resurfacing has declined. Since the potential benefits of hip resurfacing remain desirable, it may be beneficial to investigate the long-term outcome of hip resurfacings using metal-on-polyethylene in the 1980's. We report the long-term survivorship and modes of failure of a cementless metal-on-polyethylene resurfacing (n = 178) with different porous ingrowth surfaces. While acetabular loosening was absent, a high incidence of femoral failures (femoral loosening = 18.1%, osteolytic neck fracture = 21%) occurred despite using the same ingrowth surface for both components. Ongoing developments using the lessons learned from these previous generation components and utilizing modern low wear materials, e.g., cross-linked polyethylene, may lead to improved implants for future hip resurfacings.


Assuntos
Artroplastia de Quadril/métodos , Articulação do Quadril/cirurgia , Prótese de Quadril , Artropatias/cirurgia , Adolescente , Adulto , Idoso , Materiais Biocompatíveis , Feminino , Humanos , Masculino , Metais , Pessoa de Meia-Idade , Polietileno , Desenho de Prótese , Falha de Prótese , Resultado do Tratamento , Adulto Jovem
6.
J Arthroplasty ; 28(4): 695-700, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23123040

RESUMO

Thirteen male and five female patients received a Conserve Plus hip resurfacing and prospectively provided blood samples to measure cobalt and chromium levels for up to 11 years. Trends in metal levels over time in unilateral and bilateral patients were studied. A multi-variate regression model was used to account for potential covariates. For unilaterals over all time intervals, the median Serum Cobalt level (CoS) was 1.06 µg/L, while the median Serum Chromium level (CrS) was 1.58 µg/L. For bilaterals, the median post operative CoS was 2.80 µg/L, while the median CrS was 5.80 µg/L. Metal levels increased within the first year then decreased and stabilized. These results show that serum metal levels in well-functioning implants can be low and do not increase with time.


Assuntos
Artroplastia de Quadril , Cromo/sangue , Cobalto/sangue , Prótese de Quadril , Próteses Articulares Metal-Metal , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Desenho de Prótese , Fatores de Tempo
7.
Soc Sci Med ; 277: 113880, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33819865

RESUMO

Recent literature on the public understanding of science has focused on replacing the deficit model of public communication in which experts disseminate information with one that encourages public participation and dialogue. Situated within this call for increased participation, this study looks at self-care practices in which medical expertise is not passively consumed by the layperson, but shared and (re)produced through arenas of lay practice. This collective knowledge production is facilitated by the online environment, which provides access to mediated medical knowledge and the ability to form communities in which users can negotiate this expertise and share their experiences. The laypersons examined here are members of the Canadian online collective, Running Mania, highlighting how this negotiation of expertise occurs in a "wellness" community. Drawing from member interviews and website observations of the site's injury forum, the study examines collective injury management using two dominant theoretical discourses surrounding lay knowledge and participation in medical expertise: the lay expert whose knowledge arises from experience and the expert patient whose knowledge base parallels dominant biomedical discourse. Using the coproduction model and the related concepts of tinkering and logic of care from material semiotics, the research examines how these knowledge forms articulate to produce an intermediary discourse unique to this collective's articulation of running and caring practices, a discourse that is enacted in individuals' embodied negotiation of these multiple forms of medical expertise. It suggests that the logic of care has the potential to bridge the expert/lay boundary since the need for persistent, attentive tinkering applies across epistemological divides: in "good" care practices, multiple expertises are needed, both expert and lay, to hold the body together.


Assuntos
Mania , Autocuidado , Canadá , Participação da Comunidade , Humanos , Conhecimento
8.
J Am Acad Orthop Surg ; 16 Suppl 1: S49-55, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18612014

RESUMO

Orthopaedic surgeons have new tools that address the problem of aseptic loosening and osteolysis, and these tools are now in widespread clinical use. Hard-on-hard bearing couples as well as metal-on-highly cross-linked polyethylene bearing couples have lower volumetric wear rates and represent promising solutions to reduce the prevalence of osteolysis and aseptic loosening in total joint arthroplasty. Volumetric wear rates alone, however, do not completely predict the osteolytic potential that is also a function of particle composition, size, morphology, and a number of other particle characteristics. Host factors, including differing innate reactivities to wear products and adaptive immune responses, remain important but incompletely defined. Although the toxicologic significance of local and systemic elevations in metal ions has not been definitively established, monitoring patients with metal-on-metal bearings with serum metal ion levels can be useful to determine the state of the bearing. Furthermore, optimization of these bearing systems to further diminish wear and corrosion would be highly desirable.


Assuntos
Artroplastia de Substituição/instrumentação , Materiais Biocompatíveis/efeitos adversos , Reação a Corpo Estranho/imunologia , Reação a Corpo Estranho/prevenção & controle , Prótese Articular , Osteólise/prevenção & controle , Adaptação Fisiológica/imunologia , Artroplastia de Substituição/efeitos adversos , Humanos , Osteólise/etiologia , Tamanho da Partícula , Polietilenos , Desenho de Prótese , Falha de Prótese , Propriedades de Superfície
9.
J Biomed Mater Res B Appl Biomater ; 106(3): 1148-1155, 2018 04.
Artigo em Inglês | MEDLINE | ID: mdl-28556567

RESUMO

A peculiar type of surface pitting damage to revised joint replacement implant metal surfaces has been attributed to cellular activity and termed "inflammatory cell-induced-corrosion." We visually examined 1859 explanted metal implants to document the presence and extent of these features. The data was used to examine correlations between these features and the implant material, and modularity as well as clinical variables. The features were observed in approximately 77% of modular and 30% of monobloc hip implants in a variety of metals, as well as to some degree in various other implants. To test the possibility that these features were an artefact of electrocautery damage during revision surgery, a cleaned, flat, polished, CoCr disk was exposed to a variety of electrocautery interactions. This led to the production of pits and markings comparable to the published damage and to the damage found on the explants we examined. It is concluded that electrocautery damage rather than cellular activity is the cause of these features. Although rarely reported, this damage may be associated with femoral neck fracture. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1148-1155, 2018.


Assuntos
Corrosão , Eletrocoagulação , Inflamação , Metais , Próteses e Implantes , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Ligas de Cromo , Estudos de Coortes , Remoção de Dispositivo , Feminino , Seguimentos , Prótese de Quadril , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Falha de Prótese , Reoperação , Adulto Jovem
10.
Endocrinology ; 148(3): 1246-54, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17110422

RESUMO

Dlx3, a homeodomain transcription factor, is essential for placental development in the mouse. The Dlx3(-/-) mouse embryo dies at embryonic d 9.5-10 putatively due to placental failure. To develop a more comprehensive understanding of the gene profile regulated by Dlx3, microarray analysis was used to determine differences in gene expression within the placenta of Dlx3(+/+) and Dlx3(-/-) mice. Array analysis revealed differential expression of 401 genes, 33 genes in which signal to log ratio values of null/wild-type were lower than -0.5 or higher than 0.5. To corroborate these findings, quantitative real-time PCR was used to confirm differential expression for 11 genes, nine of which displayed reduced expression and two with enhanced expression in the Dlx3(-/-) mouse. Loss of Dlx3 resulted in a marked reduction (>60%) in mRNA expression of placental growth factor (Pgf), a member of the vascular endothelial growth factor family. Consistent with these results, Pgf secretion from placental explants tended to be reduced in the Dlx3(-/-) mice, compared with wild type. To investigate mechanisms of Dlx3 regulation of Pgf gene transcription, we cloned 5.2 kb of the Pgf 5' flanking sequence for use in reporter gene assays. Expression of the Pgf promoter luciferase reporter containing at least three Dlx3 binding sites was increased markedly by overexpression of Dlx3 supporting the conclusion that Dlx3 may have a direct effect on Pgf promoter activity. These studies provide a novel view of the transcriptome regulated by Dlx3 in mouse placenta. Dlx3 is specifically required for full expression and secretion of Pgf in vivo. Moreover, in vitro studies support the conclusion that Dlx3 is sufficient to directly modulate expression of the Pgf gene promoter in placental cells.


Assuntos
Perfilação da Expressão Gênica , Proteínas de Homeodomínio/fisiologia , Placenta/metabolismo , Prenhez , Fatores de Transcrição/fisiologia , Animais , Coriocarcinoma/genética , Coriocarcinoma/metabolismo , Embrião de Mamíferos , Feminino , Redes Reguladoras de Genes , Proteínas de Homeodomínio/genética , Proteínas de Homeodomínio/metabolismo , Masculino , Camundongos , Camundongos Knockout , Fator de Crescimento Placentário , Placentação , Gravidez , Proteínas da Gravidez/genética , Proteínas da Gravidez/fisiologia , Prenhez/genética , Fatores de Transcrição/genética , Fatores de Transcrição/metabolismo , Células Tumorais Cultivadas , Neoplasias Uterinas/genética , Neoplasias Uterinas/metabolismo
11.
J Bone Joint Surg Am ; 85(5): 905-11, 2003 May.
Artigo em Inglês | MEDLINE | ID: mdl-12728043

RESUMO

BACKGROUND: Bone morphogenetic proteins (BMPs) are now being used as bone-graft substitutes to enhance spinal fusion. However, the large doses of BMP required to induce a spinal fusion in humans suggests that the delivery of these proteins should be improved. We used ex vivo adenoviral gene transfer to create BMP-2-producing bone marrow cells, and these autologous cells were found to induce a posterolateral fusion of the spine in syngeneic rats. METHODS: Intertransverse spinal arthrodesis (L4 and L5) was attempted in ten groups of Lewis rats with 5 x 10 (6) BMP-2-producing rat bone marrow cells (Ad-BMP-2 cells), created through adenoviral gene transfer with guanidine hydrochloride-extracted demineralized bone matrix as a carrier (Group I); 5 x 10 (6) Ad-BMP-2 cells on a collagen sponge carrier (Group II); 10 micro g of recombinant BMP-2 (rhBMP-2) in a guanidine hydrochloride-extracted demineralized bone matrix carrier (Group III); 10 micro g of rhBMP-2 in a collagen sponge carrier (Group IV); autogenous iliac crest bone-grafting (Group V); 5 x 10 (6) beta-galactosidase-producing rat bone marrow cells, created through adenoviral gene transfer with guanidine hydrochloride-extracted demineralized bone matrix as a carrier (Group VI); decortication of the transverse processes alone (Group VII); 5 x 10 (6) uninfected rat bone marrow cells with a guanidine hydrochloride-extracted demineralized bone matrix carrier (Group VIII); guanidine hydrochloride-extracted demineralized bone matrix only (Group IX); or a collagen sponge alone (Group X). Each specimen underwent plain radiography, manual palpation, and histological analysis. RESULTS: All spines in Groups I and II (BMP-2-producing bone marrow cells) and all spines in Groups III and IV were fused at four weeks postoperatively. In contrast, none of the spines in the other groups had fused at a minimum of eight weeks after implantation. Histological analysis of the specimens revealed that the spines that had received BMP-2-producing bone marrow cells (Groups I and II) were filled with coarse trabecular bone postoperatively, whereas those that had received rhBMP-2 (Groups III and IV) were filled with thin, lace-like trabecular bone. All of the other spines, including those that had been treated with autogenous iliac crest bone-grafting (Group V), produced little or no new bone. CONCLUSION: BMP-2-producing bone marrow cells, created by adenoviral gene transfer, produce sufficient BMP to induce an intertransverse fusion in the rat spine model.


Assuntos
Proteínas Morfogenéticas Ósseas/genética , Terapia Genética/métodos , Fusão Vertebral/métodos , Transplante de Células-Tronco , Transdução Genética/métodos , Fator de Crescimento Transformador beta , Animais , Proteína Morfogenética Óssea 2 , Proteínas Morfogenéticas Ósseas/metabolismo , Feminino , Radiografia , Ratos , Ratos Endogâmicos Lew , Coluna Vertebral/diagnóstico por imagem
12.
J Orthop Res ; 32(6): 735-43, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24619566

RESUMO

During revision of a conventional polyethylene joint replacement, surgeons usually remove the source of osteolysis (polyethylene) but cannot always remove all of the polyethylene granuloma tissues. We developed a human/rat xenograft model to investigate the effects of polyethylene granuloma tissues on bone healing. Human osteoarthritic and periprosthetic tissues collected during primary and revision hip arthroplasty surgeries were transplanted into the distal femora of athymic nude rats. After 3 weeks in vivo, there was a significant difference in the bone volume fraction (Vf ) between empty, primary, and revision defects (p = 0.02), with a lower Vf in defects with revision granuloma tissues compared to defects with primary osteoarthritic tissues. Polyethylene granuloma tissues in trabecular bone defects inhibited bone healing. Therefore, debridement around a metal-on-polyethylene hip replacement may shorten the time it takes to achieve secondary stability around a revision hip replacement.


Assuntos
Granuloma de Corpo Estranho/fisiopatologia , Osteólise/cirurgia , Polietileno/efeitos adversos , Cicatrização/fisiologia , Animais , Artroplastia de Quadril , Desbridamento , Xenoenxertos , Humanos , Osseointegração/fisiologia , Ratos , Cicatrização/efeitos dos fármacos
14.
Orthop Clin North Am ; 42(2): 181-93, viii, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21435494

RESUMO

Narrowing of the femoral neck after metal-on-metal hip resurfacing arthoplasty has been reported as a common radiologic feature, although its significance is still unknown. This study reports the presence and significance of neck narrowing in the first 500 consecutive Conserve® Plus metal-on-metal hip resurfacings in 431 patients.


Assuntos
Artroplastia de Quadril/métodos , Colo do Fêmur/patologia , Feminino , Prótese de Quadril , Humanos , Masculino , Metais , Pessoa de Meia-Idade , Osteoartrite do Quadril/patologia , Osteoartrite do Quadril/cirurgia , Osteonecrose/patologia , Osteonecrose/cirurgia , Desenho de Prótese
15.
Orthop Clin North Am ; 42(2): 207-30, viii, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21435496

RESUMO

This article determines the incidence and cause of the complications commonly associated with metal-on-metal hip resurfacing implants and the proposed methods to prevent these complications. The literature available in PubMed was reviewed. Complication rates after hip resurfacing are low, and the procedure has shown both safety and efficacy in the hands of surgeons trained in specialized centers. Proper surgical technique can further reduce the incidence of femoral neck fracture, component loosening, and abnormal wear of the prosthesis. A more systematic detection of adverse local tissue reactions is needed to provide accurate assessments of their prevalence.


Assuntos
Artroplastia de Quadril/efeitos adversos , Artroplastia de Quadril/métodos , Cimentação , Fraturas do Colo Femoral/epidemiologia , Fraturas do Colo Femoral/prevenção & controle , Prótese de Quadril , Humanos , Incidência , Osteoartrite do Quadril/terapia , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/prevenção & controle , Falha de Prótese , Ajuste de Prótese , Reoperação , Estresse Mecânico
16.
Orthop Clin North Am ; 42(2): 241-50, ix, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21435498

RESUMO

Metal-on-metal total hip replacements (THRs) and hip resurfacings are coming under increasing scrutiny in light of concerns that they fail because of high wear and elevated metal ions. The aim of this study was to investigate the modes of failure in a collection of 433 metal-on-metal THRs and hip resurfacings and to examine the correlations between the reasons for revision and a range of patient and implant variables considered relevant to implant wear.


Assuntos
Análise de Falha de Equipamento , Prótese de Quadril , Falha de Prótese , Feminino , Humanos , Hipersensibilidade/etiologia , Masculino , Metais/efeitos adversos , Osteoartrite do Quadril/cirurgia , Desenho de Prótese , Estudos Retrospectivos
18.
J Bone Joint Surg Am ; 92(16): 2663-71, 2010 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-21084576

RESUMO

BACKGROUND: There was a need for information about the long-term performance of the modern generation of hip resurfacing implants. A retrospective review of the first 100 hips that had implantation of one resurfacing design and had been followed for a minimum of ten years was performed. METHODS: Between 1996 and 1998, 100 CONSERVE PLUS hip resurfacing devices were implanted by a single surgeon in eighty-nine patients. The mean age of the patients was 49.1 years, and fifty-nine patients were male. Primary osteoarthritis was the etiology for sixty-four hips. All patients were assessed clinically and radiographically. RESULTS: The mean duration of follow-up was 11.7 years (range, 10.8 to 12.9 years). Two patients were lost to follow-up, and five patients died of causes unrelated to the surgery. Eleven hips had conversion to total hip arthroplasty because of loosening of the femoral component (eight), a femoral neck fracture (one), recurrent subluxation (one), and late infection (one). The Kaplan-Meier survivorship was 88.5% at ten years. None of the resurfacing arthroplasties failed in the twenty-eight hips that had a femoral component of >46 mm and no femoral head cystic or necrotic defects of >1 cm. Five hips had narrowing of the femoral neck, three had radiolucent zones interpreted as osteolysis, and twenty had signs of neck-socket impingement. Five hips had radiolucencies around the metaphyseal stem (two partial and three complete) that had been stable for 7.8 to 10.2 years. The mean scores on the University of California at Los Angeles (UCLA) system at the time of the latest follow-up were 9.5 points for pain, 9.3 points for walking, 8.9 points for function, and 6.8 points for activity; the mean scores on the physical and mental components of the Short Form-12 (SF-12) were 47.3 and 50.5 points, respectively; and the mean Harris hip score was 90 points. CONCLUSIONS: The results of the present series constitute a reference point to which subsequent series should be compared. These ten-year results in a group of young patients are satisfactory, and the low rate of osteolysis is encouraging, but longer follow-up is required for comparison with conventional total hip arthroplasty.


Assuntos
Artroplastia de Quadril/métodos , Articulação do Quadril/diagnóstico por imagem , Articulação do Quadril/cirurgia , Prótese de Quadril , Adolescente , Adulto , Idoso , Artroplastia de Quadril/efeitos adversos , Estudos de Coortes , Feminino , Cabeça do Fêmur/diagnóstico por imagem , Cabeça do Fêmur/cirurgia , Seguimentos , Articulação do Quadril/fisiopatologia , Humanos , Estimativa de Kaplan-Meier , Masculino , Metais , Pessoa de Meia-Idade , Análise Multivariada , Procedimentos Ortopédicos/efeitos adversos , Procedimentos Ortopédicos/métodos , Medição da Dor , Dor Pós-Operatória/fisiopatologia , Complicações Pós-Operatórias/diagnóstico por imagem , Complicações Pós-Operatórias/fisiopatologia , Modelos de Riscos Proporcionais , Desenho de Prótese , Falha de Prótese , Radiografia , Amplitude de Movimento Articular/fisiologia , Estudos Retrospectivos , Medição de Risco , Estatísticas não Paramétricas , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
19.
J Arthroplasty ; 22(4): 481-9, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17562402

RESUMO

The purpose of the present study was to determine the effectiveness of modifications in the surgical technique on loosening of the femoral component in the first 600 consecutive Conserve Plus metal-on-metal hybrid resurfacings (Wright Medical Technologies, Arlington, Tenn). These modifications were gradually introduced over time, but all the changes were implemented after the first 300 hips. The average age of the patients was 48.9 years, and 74% were male. The average follow-up was 70.5 months for the first 300 hips and 42.4 months for the second 300, and there was a significant improvement (P = .016) of the second 300 hips over the first 300 in a time-dependent analysis using as an end point the time to appearance of a radiolucency, suggesting potential femoral component loosening. None of the components with cemented stems showed femoral radiolucencies or were revised for aseptic loosening. Adding fixation holes in the dome and chamfered areas and cleansing and drying using a suction tip in the dome hole were significantly related to the improvement of the results. Positioning the femoral component in a more valgus position did not show any effect as an independent variable.


Assuntos
Artroplastia de Quadril/métodos , Adolescente , Adulto , Idoso , Cimentação/métodos , Feminino , Fêmur , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Falha de Prótese , Reoperação
20.
J Biol Chem ; 281(29): 20357-67, 2006 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-16687405

RESUMO

Dlx3 (Distal-less 3) is a homeobox-containing transcription factor required for normal placental development in mice. Here we demonstrate that Dlx3 interacts with Smad6, a member of a larger family of transcriptional regulators generally thought to regulate transforming growth factor beta/bone morphogenetic protein signaling. Immunocytochemical and immunoprecipitation studies demonstrate overlapping nuclear localization and physical interaction between Dlx3 and Smad6 in human choriocarcinoma cells and in differentiated trophoblasts from human placenta. In vitro protein interaction studies mapped the Smad6 interaction domain within Dlx3 to residues 80-163, a region of Dlx3 that includes a portion of the homeodomain. Dlx3 and Dlx4 share homology within this region, and Dlx4 was also found to bind Smad6. Using the Esx1 gene promoter as a model for a Dlx3-responsive gene, studies demonstrate two near consensus Dlx3 binding sites within the proximal 2.3 kb of the transcription start site. Interestingly, binding of Dlx3 to one of these two sites was inhibited by interaction with Smad6. Consistent with this result, expression of an Esx1 promoter luciferase reporter was increased by overexpression of Dlx3; this effect was reversed with co-expression of Smad6. Further, small interference RNA-mediated knockdown of endogenous Smad6 increased Dlx3-dependent expression of the Esx1 gene promoter. Thus, Smad6 appears to functionally interact with Dlx3, altering the ability of Dlx3 to bind target gene promoters. Smad6 appears to play a modulatory role in the regulation of Dlx3-dependent gene transcription within placental trophoblasts.


Assuntos
DNA/metabolismo , Proteínas de Homeodomínio/antagonistas & inibidores , Proteína Smad6/metabolismo , Fatores de Transcrição/antagonistas & inibidores , Transcrição Gênica/fisiologia , Sequência de Aminoácidos , Sequência de Bases , Linhagem Celular , Núcleo Celular/fisiologia , Sequência Consenso , DNA/antagonistas & inibidores , Primers do DNA , Feminino , Proteínas de Homeodomínio/genética , Humanos , Dados de Sequência Molecular , Placenta/fisiologia , Gravidez , Regiões Promotoras Genéticas , Proteínas Recombinantes/metabolismo , Fatores de Transcrição/genética
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